AromaDb: A Database of Plant's Aroma Molecules

Phenyl Ethyl Alcohol Details

: IUPAC Name
2-(4-hydroxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol
:Chemical Class
Alcohol
:CAS Registry Number
35354-74-6
:Description

:Fragrance Type

Physical and Chemical properties

PUBCHEM ID72303
Molecular Weight (mg/mol)266.334
Molecular FormulaC18H18O2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count5
IUPAC Name2-(4-hydroxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol
Canonical SMILESC=CCc2ccc(O)c(c1ccc(O)c(CC=C)c1)c2
PUBCHEM IUPAC INCHIKEYFVYXIJYOAGAUQK-UHFFFAOYSA-N
Solubility Level2
Vapour Pressure-7.321

Absorption and Metabolism information

XLOGP3 AA5
CACTVS TPSA40.5
BBB Level1
Absorption Level0
EXT PPB#Prediction1
AlogP984.88
EXT CYP2D6#Prediction1

Toxicological Information

Mouse Female FDANon-Carcinogen
Mouse Male FDANon-Carcinogen
Rat Female FDANon-Carcinogen
Rat Male FDANon-Carcinogen
Ames PredictionNon-Mutagen
Developmental / Reproductive ToxicityToxic
Rat Oral LD500.788782 g/kg_body_weight
Ocular IrritancyMild
Hepatotoxic#Prediction1
Effected Human Genes

Ecological Information

Aerobic Biodegradability PredictionNon-Degradable

Hazard(s) Identification

Physical hazardsnot classified
Health hazards None
Environmental hazardsnot classified
About Table Headings

Compound Biological Activity

Serial No.Cas No Gene SymbolOrganismInteraction Interaction ActionsPubMed Id
1 35354-74-6 ACACA Rattus norvegicus honokiol inhibits the reaction [Ethanol results in increased expression of ACACA mRNA] decreases^reaction|increases^expression 19371623
2 35354-74-6 ACACA Rattus norvegicus honokiol results in decreased expression of ACACA mRNA decreases^expression 19371623
3 35354-74-6 ACLY Rattus norvegicus honokiol results in decreased expression of ACLY mRNA decreases^expression 19371623
4 35354-74-6 ACTA2 Rattus norvegicus honokiol affects the expression of ACTA2 protein affects^expression 21265825
5 35354-74-6 ACTA2 Rattus norvegicus honokiol inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] decreases^reaction|increases^expression 21265825
6 35354-74-6 ALOX15 Homo sapiens ALOX15 protein promotes the reaction [honokiol results in decreased expression of PPARG protein] decreases^expression|increases^reaction 20649594
7 35354-74-6 ALOX15 Homo sapiens ALOX15 protein promotes the reaction [honokiol results in decreased expression of PTGS2 protein] decreases^expression|increases^reaction 20649594
8 35354-74-6 ALOX15 Homo sapiens honokiol results in increased expression of ALOX15 mRNA increases^expression 20649594
9 35354-74-6 ALOX15 Homo sapiens honokiol results in increased expression of ALOX15 protein increases^expression 20649594
10 35354-74-6 ALOX15 Homo sapiens [honokiol results in increased expression of ALOX15 protein] which results in increased abundance of hydroxyoctadecadienoic acid increases^abundance|increases^expression 20649594
11 35354-74-6 BAX Homo sapiens honokiol results in increased expression of BAX protein increases^expression 15802533
12 35354-74-6 CASP3 Homo sapiens honokiol results in increased activity of CASP3 protein increases^activity 15802533|25106108
13 35354-74-6 CASP8 Homo sapiens honokiol results in increased activity of CASP8 protein increases^activity 15802533
14 35354-74-6 CASP9 Homo sapiens honokiol results in increased activity of CASP9 protein increases^activity 15802533|25106108
15 35354-74-6 CCL2 Rattus norvegicus honokiol affects the expression of CCL2 mRNA affects^expression 21265825
16 35354-74-6 CCL3 Homo sapiens honokiol inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 protein] decreases^reaction|increases^expression 21147091
17 35354-74-6 COL1A1 Rattus norvegicus honokiol affects the expression of COL1A1 mRNA affects^expression 21265825
18 35354-74-6 COL1A1 Rattus norvegicus honokiol inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein] decreases^reaction|increases^expression 21265825
19 35354-74-6 CTGF Homo sapiens honokiol inhibits the reaction [TGFB1 protein results in increased expression of CTGF mRNA] decreases^reaction|increases^expression 21265825
20 35354-74-6 CTGF Rattus norvegicus honokiol affects the expression of CTGF mRNA affects^expression 21265825
21 35354-74-6 CTGF Rattus norvegicus honokiol inhibits the reaction [TGFB1 protein results in increased expression of CTGF protein] decreases^reaction|increases^expression 21265825
22 35354-74-6 FAS Rattus norvegicus honokiol inhibits the reaction [Ethanol promotes the reaction [SREBF1 protein binds to FAS promoter]] affects^binding|decreases^reaction|increases^reaction 19371623
23 35354-74-6 FAS Rattus norvegicus honokiol inhibits the reaction [Ethanol results in increased expression of FAS mRNA] decreases^reaction|increases^expression 19371623
24 35354-74-6 FAS Rattus norvegicus honokiol results in decreased expression of FAS mRNA decreases^expression 19371623
25 35354-74-6 FN1 Rattus norvegicus honokiol affects the expression of FN1 mRNA affects^expression 21265825
26 35354-74-6 FN1 Rattus norvegicus honokiol inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein] decreases^reaction|increases^expression 21265825
27 35354-74-6 GABRA1 [Diazepam co-treated with honokiol] results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein] affects^binding|affects^cotreatment|increases^activity 21699169
28 35354-74-6 GABRA1 honokiol results in increased activity of [GABRA1 protein binds to GABRB2 protein] affects^binding|increases^activity 21699169
29 35354-74-6 GABRA1 honokiol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein] affects^binding|increases^activity 21699169
30 35354-74-6 GABRA1 honokiol results in increased activity of [GABRA1 protein binds to GABRB3 protein] affects^binding|increases^activity 21699169
31 35354-74-6 GABRA2 honokiol results in increased activity of [GABRA2 protein binds to GABRB2 protein] affects^binding|increases^activity 21699169
32 35354-74-6 GABRA3 honokiol results in increased activity of [GABRA3 protein binds to GABRB2 protein] affects^binding|increases^activity 21699169
33 35354-74-6 GABRA5 honokiol results in increased activity of [GABRA5 protein binds to GABRB2 protein] affects^binding|increases^activity 21699169
34 35354-74-6 GLO1 Mus musculus honokiol inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein] decreases^activity|decreases^reaction 26723916
35 35354-74-6 ICAM1 Rattus norvegicus honokiol affects the expression of ICAM1 mRNA affects^expression 21265825
36 35354-74-6 IL18 Homo sapiens honokiol inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 protein] decreases^reaction|increases^expression 21147091
37 35354-74-6 IL1B Homo sapiens honokiol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] decreases^reaction|increases^expression 21147091
38 35354-74-6 IL4 Homo sapiens honokiol results in decreased activity of IL4 protein decreases^activity 15802533
39 35354-74-6 IL6 Mus musculus honokiol affects the reaction [Pyruvaldehyde results in increased expression of IL6 protein] affects^reaction|increases^expression 26723916
40 35354-74-6 LYN honokiol results in decreased activity of LYN protein decreases^activity 25980585
41 35354-74-6 MCL1 Homo sapiens honokiol results in decreased expression of MCL1 protein decreases^expression 15802533
42 35354-74-6 NFKB1 Mus musculus honokiol analog inhibits the reaction [Lipopolysaccharides results in increased localization of and results in increased activity of NFKB1 protein] decreases^reaction|increases^activity|increases^localization 19539808
43 35354-74-6 NFKB1 Mus musculus honokiol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased localization of and results in increased activity of NFKB1 protein] decreases^reaction|increases^activity|increases^localization 19539808
44 35354-74-6 NOS2 Homo sapiens honokiol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Dinoprostone] decreases^reaction|increases^chemical synthesis|increases^expression 21147091
45 35354-74-6 NOS2 Mus musculus honokiol analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] decreases^reaction|increases^expression 19539808
46 35354-74-6 NOS2 Mus musculus honokiol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] decreases^reaction|increases^expression 19539808
47 35354-74-6 PPARG Homo sapiens honokiol binds to and results in increased activity of PPARG protein affects^binding|increases^activity 23811337
48 35354-74-6 PPARG Homo sapiens honokiol results in decreased expression of PPARG mRNA decreases^expression 20649594
49 35354-74-6 PPARG Homo sapiens honokiol results in decreased expression of PPARG protein decreases^expression 20649594
50 35354-74-6 PPARGC1A Mus musculus [Pyruvaldehyde co-treated with honokiol] results in increased expression of PPARGC1A protein affects^cotreatment|increases^expression 26723916
51 35354-74-6 PTGS2 Homo sapiens honokiol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] decreases^reaction|increases^expression 21147091
52 35354-74-6 PTGS2 Homo sapiens honokiol results in decreased expression of PTGS2 mRNA decreases^expression 20649594
53 35354-74-6 PTGS2 Homo sapiens honokiol results in decreased expression of PTGS2 protein decreases^expression 20649594
54 35354-74-6 PTGS2 Mus musculus honokiol analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] decreases^reaction|increases^expression 19539808
55 35354-74-6 PTGS2 Mus musculus honokiol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] decreases^reaction|increases^expression 19539808
56 35354-74-6 RELA Mus musculus honokiol analog inhibits the reaction [Lipopolysaccharides results in increased localization of and results in increased activity of RELA protein] decreases^reaction|increases^activity|increases^localization 19539808
57 35354-74-6 RELA Mus musculus honokiol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased localization of and results in increased activity of RELA protein] decreases^reaction|increases^activity|increases^localization 19539808
58 35354-74-6 SCD1 Rattus norvegicus honokiol results in decreased expression of SCD1 mRNA decreases^expression 19371623
59 35354-74-6 SERPINE1 Rattus norvegicus honokiol affects the expression of SERPINE1 mRNA affects^expression 21265825
60 35354-74-6 SERPINE1 Rattus norvegicus honokiol inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein] decreases^reaction|increases^expression 21265825
61 35354-74-6 SREBF1 Rattus norvegicus honokiol inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA] decreases^reaction|increases^expression 19371623
62 35354-74-6 SREBF1 Rattus norvegicus honokiol results in decreased expression of SREBF1 mRNA decreases^expression 19371623
63 35354-74-6 TGFB1 Homo sapiens honokiol inhibits the reaction [Lipopolysaccharides results in increased expression of TGFB1 protein] decreases^reaction|increases^expression 21147091
64 35354-74-6 TGFB1 Rattus norvegicus honokiol affects the expression of TGFB1 affects^expression 21265825
65 35354-74-6 TNF Homo sapiens honokiol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] decreases^reaction|increases^expression 21147091
66 35354-74-6 TNF Mus musculus honokiol inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein] decreases^reaction|increases^expression 26723916
67 35354-74-6 TNF Rattus norvegicus honokiol inhibits the reaction [Ethanol results in increased expression of TNF protein] decreases^reaction|increases^expression 19371623
Serial No.Activity Name DetailsReferences (PubMed)Other details EPA (U.S)Clinical Trials (U.S. NIH)
1 35354-74-6 Phenyl Ethyl Alcohol

Plant Variety and Essential oils

Serial No.Plant NameVariety NameEssential OilCompound Percentage
1 Rose, Damask Rose Noorjahan Rosa damascena Noorjahan essential oil
2 Rose, Damask Rose Ranisahiba Rose Ranisahiba essential oil

Compound Image


2D Structure

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