AromaDb: A Database of Plant's Aroma Molecules

Dihydronaringenin Details

: IUPAC Name
3-4-Hydroxy-phenyl-1-2,4,6-trihydroxy-phenyl-propan-1-one
:Chemical Class
:CAS Registry Number
60-82-2
:Description

:Fragrance Type
Sweet aroma

Physical and Chemical properties

PUBCHEM ID4788
Molecular Weight (mg/mol)274.277
Molecular FormulaC15H14O5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count8
IUPAC Name3-4-Hydroxy-phenyl-1-2,4,6-trihydroxy-phenyl-propan-1-one
Canonical SMILESO=C(CCc1ccc(O)cc1)c2c(O)cc(O)cc2O
PUBCHEM IUPAC INCHIKEYVGEREEWJJVICBM-UHFFFAOYSA-N
Solubility Level3
Vapour Pressure-10.014

Absorption and Metabolism information

XLOGP3 AANA
CACTVS TPSA38.69
BBB Level3
Absorption Level0
EXT PPB#Prediction0
AlogP982.757
EXT CYP2D6#Prediction1

Toxicological Information

Mouse Female FDANon-Carcinogen
Mouse Male FDANon-Carcinogen
Rat Female FDANon-Carcinogen
Rat Male FDANon-Carcinogen
Ames PredictionNon-Mutagen
Developmental / Reproductive ToxicityToxic
Rat Oral LD504.875
Ocular IrritancySevere
Hepatotoxic#Prediction1
Effected Human GenesNA

Ecological Information

Aerobic Biodegradability PredictionNon-Degradable

Hazard(s) Identification

Physical hazardsnot classified
Health hazards None
Environmental hazardsnot classified
About Table Headings

Compound Biological Activity

Serial No.Cas No Gene SymbolOrganismInteraction Interaction ActionsPubMed Id
1 60-82-2 AFP Rattus norvegicus Phloretin binds to AFP protein affects^binding 23013281|25349334
2 60-82-2 AQP9 Rattus norvegicus Phloretin results in decreased activity of AQP9 protein decreases^activity 21259319|9733774
3 60-82-2 CCL2 Homo sapiens Phloretin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein] decreases^reaction|increases^expression 24707119
4 60-82-2 CCL5 Homo sapiens Phloretin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 protein] decreases^reaction|increases^expression 24707119
5 60-82-2 CSF3 Homo sapiens Phloretin inhibits the reaction [Lipopolysaccharides results in increased expression of CSF3 protein] decreases^reaction|increases^expression 24707119
6 60-82-2 CYP1A1 Homo sapiens Phloretin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] decreases^reaction|increases^activity 17177569
7 60-82-2 CYP1A1 Homo sapiens Phloretin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] decreases^reaction|increases^expression 17177569
8 60-82-2 CYP1A1 Homo sapiens Phloretin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein] decreases^reaction|increases^expression 17177569
9 60-82-2 ESR1 Homo sapiens Phloretin binds to and results in increased activity of ESR1 protein affects^binding|increases^activity 9751507
10 60-82-2 ESR2 Homo sapiens Phloretin binds to and results in increased activity of ESR2 protein affects^binding|increases^activity 9751507
11 60-82-2 ESR2 Homo sapiens Phloretin binds to ESR2 protein affects^binding 12224631
12 60-82-2 GSK3B Homo sapiens Phloretin results in decreased activity of GSK3B protein decreases^activity 16968061
13 60-82-2 IFNG Homo sapiens Phloretin inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein] decreases^reaction|increases^expression 24707119
14 60-82-2 IL10 Homo sapiens Phloretin inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein] decreases^reaction|increases^expression 24707119
15 60-82-2 IL1A Homo sapiens Phloretin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A protein] decreases^reaction|increases^expression 24707119
16 60-82-2 IL1RN Homo sapiens Phloretin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1RN protein] decreases^reaction|increases^expression 24707119
17 60-82-2 IL6 Homo sapiens Phloretin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] decreases^reaction|increases^expression 24707119
18 60-82-2 INS Homo sapiens Phloretin inhibits the reaction [[chromic chloride results in increased activity of INS protein modified form] which results in increased secretion of Adenosine Triphosphate] decreases^reaction|increases^activity|increases^secretion 17965850
19 60-82-2 KCNMA1 Rattus norvegicus KCNMA1 mRNA affects the susceptibility to Phloretin affects^response to substance 19247476
20 60-82-2 LTF Rattus norvegicus Phloretin results in increased expression of LTF protein increases^expression 24487097
21 60-82-2 NOS3 Homo sapiens Phloretin inhibits the reaction [Hydrogen Peroxide results in increased expression of NOS3 mRNA] decreases^reaction|increases^expression 20021702
22 60-82-2 NOS3 Homo sapiens Phloretin results in decreased expression of NOS3 mRNA decreases^expression 20021702
23 60-82-2 SHBG Homo sapiens Phloretin binds to SHBG protein affects^binding 25349334
24 60-82-2 SLC16A1 Rattus norvegicus [[Luteolin co-treated with Phloretin] results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate affects^cotreatment|decreases^activity|decreases^uptake 17108059
25 60-82-2 SLC16A1 Rattus norvegicus [Phloretin results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate decreases^activity|decreases^uptake 17108059
26 60-82-2 SLC2A1 Homo sapiens Phloretin results in decreased activity of SLC2A1 protein decreases^activity 14642735
27 60-82-2 SLC2A1 Sus scrofa Phloretin promotes the reaction [Cyclosporine results in increased expression of SLC2A1 mRNA] increases^expression|increases^reaction 12081571
28 60-82-2 SLC2A1 Sus scrofa Phloretin promotes the reaction [Cyclosporine results in increased expression of SLC2A1 protein] increases^expression|increases^reaction 12081571
29 60-82-2 SLC2A1 Sus scrofa Phloretin results in increased expression of SLC2A1 mRNA increases^expression 12081571
30 60-82-2 SLC2A1 Sus scrofa Phloretin results in increased expression of SLC2A1 protein increases^expression 12081571
31 60-82-2 SLC2A2 Homo sapiens Phloretin results in decreased expression of SLC2A2 protein decreases^expression 26616219
32 60-82-2 SLC9A1 Homo sapiens Phloretin inhibits the reaction [SLC9A1 protein alternative form affects the transport of [Sodium co-treated with Lithium]] affects^cotreatment|affects^transport|decreases^reaction 12765964
33 60-82-2 SLC9A1 Homo sapiens Phloretin results in decreased activity of SLC9A1 protein decreases^activity 12765964
34 60-82-2 SLC9A1 Homo sapiens Phloretin results in decreased activity of SLC9A1 protein alternative form decreases^activity 12765964
35 60-82-2 SLC9B2 Homo sapiens Phloretin results in decreased activity of SLC9B2 protein decreases^activity 18000046
36 60-82-2 SLCO2B1 [Phlorhizin co-treated with Phloretin co-treated with Hesperidin co-treated with Quercetin] inhibits the reaction [SLCO2B1 protein results in increased uptake of estrone sulfate] affects^cotreatment|decreases^reaction|increases^uptake 23794501
37 60-82-2 THRA Rana catesbeiana Phloretin inhibits the reaction [Triiodothyronine metabolite binds to THRA protein] affects^binding|decreases^reaction 15590988
38 60-82-2 THRA Rana catesbeiana Phloretin inhibits the reaction [Triiodothyronine metabolite results in increased expression of THRA mRNA] decreases^reaction|increases^expression 15590988
39 60-82-2 TYR Phloretin results in decreased activity of TYR protein decreases^activity 24613711
40 60-82-2 TYR phloretin isonicotinyl hydrazone results in decreased activity of TYR protein decreases^activity 24613711
Serial No.Activity Name DetailsReferences (PubMed)Other details EPA (U.S)Clinical Trials (U.S. NIH)
1 60-82-2 Dihydronaringenin

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