AromaDb: A Database of Plant's Aroma Molecules

Dibunol Details

: IUPAC Name
2,6-ditert-butyl-4-methylphenol
:Chemical Class
Alcohol
:CAS Registry Number
128-37-0
:Description

:Fragrance Type

Physical and Chemical properties

PUBCHEM ID31404
Molecular Weight (mg/mol)220.35
Molecular FormulaC15H24O
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count2
IUPAC Name2,6-ditert-butyl-4-methylphenol
Canonical SMILESCc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1
PUBCHEM IUPAC INCHIKEYNLZUEZXRPGMBCV-UHFFFAOYSA-N
Solubility Level2
Vapour Pressure-2.649

Absorption and Metabolism information

XLOGP3 AA5.3
CACTVS TPSA20.2
BBB Level0
Absorption Level0
EXT PPB#Prediction1
AlogP984.874
EXT CYP2D6#Prediction0

Toxicological Information

Mouse Female FDANon-Carcinogen
Mouse Male FDAMulti-Carcinogen
Rat Female FDANon-Carcinogen
Rat Male FDANon-Carcinogen
Ames PredictionNon-Mutagen
Developmental / Reproductive ToxicityToxic
Rat Oral LD500.778548 g/kg_body_weight
Ocular IrritancyModerate
Hepatotoxic#Prediction0
Effected Human Genes

Ecological Information

Aerobic Biodegradability PredictionNon-Degradable

Hazard(s) Identification

Physical hazardsnot classified
Health hazards Mild
Environmental hazardsnot classified
About Table Headings

Compound Biological Activity

Serial No.Cas No Gene SymbolOrganismInteraction Interaction ActionsPubMed Id
1 128-37-0 NR3C1 2,2'-methylenebis(ethyl-6-tert-butylphenol) results in decreased expression of NR3C1 mRNA decreases^expression 24518828
2 128-37-0 AHR Mus musculus 2,6-di-tert-butyl-4-hydroxy-4-methyl-2,5-cyclohexadien-1-one binds to and results in decreased activity of AHR protein affects^binding|decreases^activity 27633901
3 128-37-0 AR Homo sapiens 2,6-di-tert-butyl-4-hydroxy-4-methyl-2,5-cyclohexadien-1-one binds to and results in decreased activity of AR protein affects^binding|decreases^activity 27633901
4 128-37-0 ESR1 Homo sapiens 2,6-di-tert-butyl-4-hydroxy-4-methyl-2,5-cyclohexadien-1-one binds to and results in decreased activity of ESR1 protein affects^binding|decreases^activity 27633901
5 128-37-0 NR3C1 Homo sapiens 2,6-di-tert-butyl-4-hydroxy-4-methyl-2,5-cyclohexadien-1-one binds to and results in decreased activity of NR3C1 protein affects^binding|decreases^activity 27633901
6 128-37-0 PGR Homo sapiens 2,6-di-tert-butyl-4-hydroxy-4-methyl-2,5-cyclohexadien-1-one binds to and results in decreased activity of PGR protein affects^binding|decreases^activity 27633901
7 128-37-0 THRB Homo sapiens 2,6-di-tert-butyl-4-hydroxy-4-methyl-2,5-cyclohexadien-1-one binds to and results in increased activity of THRB protein affects^binding|increases^activity 27633901
8 128-37-0 AR Homo sapiens 2,6-di-tert-butyl-4-hydroxymethylphenol inhibits the reaction [Metribolone results in increased activity of AR protein] decreases^reaction|increases^activity 18324785
9 128-37-0 CASP3 Homo sapiens 2-tert-butyl-4-methylphenol results in decreased activity of CASP3 protein decreases^activity 14981915
10 128-37-0 CAT 2-tert-butyl-4-methylphenol inhibits the reaction [1-hydroxyethyl radical results in decreased activity of CAT protein] decreases^activity|decreases^reaction 10600175
11 128-37-0 SOD2 Homo sapiens 2-tert-butyl-4-methylphenol results in decreased expression of SOD2 mRNA decreases^expression 14981915
12 128-37-0 AR Homo sapiens 3,5-di-tert-butyl-4-hydroxybenzaldehyde binds to and results in decreased activity of AR protein affects^binding|decreases^activity 27633901
13 128-37-0 ESR1 Homo sapiens 3,5-di-tert-butyl-4-hydroxybenzaldehyde binds to and results in decreased activity of ESR1 protein affects^binding|decreases^activity 27633901
14 128-37-0 NR3C1 Homo sapiens 3,5-di-tert-butyl-4-hydroxybenzaldehyde binds to and results in decreased activity of NR3C1 protein affects^binding|decreases^activity 27633901
15 128-37-0 PGR Homo sapiens 3,5-di-tert-butyl-4-hydroxybenzaldehyde binds to and results in decreased activity of PGR protein affects^binding|decreases^activity 27633901
16 128-37-0 PPARG Homo sapiens 3,5-di-tert-butyl-4-hydroxybenzaldehyde binds to and results in decreased activity of PPARG protein affects^binding|decreases^activity 27633901
17 128-37-0 THRB Homo sapiens 3,5-di-tert-butyl-4-hydroxybenzaldehyde binds to and results in decreased activity of THRB protein affects^binding|decreases^activity 27633901
18 128-37-0 ACTG1 Mus musculus BHTOH-QM binds to ACTG1 protein affects^binding 16533022
19 128-37-0 ACTN2 Mus musculus BHTOH-QM binds to ACTN2 protein affects^binding 16533022
20 128-37-0 ANXA3 Mus musculus BHTOH-QM binds to ANXA3 protein affects^binding 16533022
21 128-37-0 CBR2 Mus musculus BHTOH-QM results in decreased activity of CBR2 protein decreases^activity 18597497
22 128-37-0 CCT8 Mus musculus BHTOH-QM binds to CCT8 protein affects^binding 16533022
23 128-37-0 EEF1A1 Mus musculus BHTOH-QM binds to EEF1A1 protein affects^binding 16533022
24 128-37-0 ENO1 Mus musculus BHTOH-QM binds to ENO1 protein affects^binding 16533022
25 128-37-0 HDLBP Mus musculus BHTOH-QM binds to HDLBP protein affects^binding 16533022
26 128-37-0 HNRNPA2B1 Mus musculus BHTOH-QM binds to HNRNPA2B1 protein affects^binding 16533022
27 128-37-0 HSP90AA1 Mus musculus BHTOH-QM binds to HSP90AA1 protein affects^binding 16533022
28 128-37-0 HSP90AB1 Mus musculus BHTOH-QM binds to HSP90AB1 protein affects^binding 16533022
29 128-37-0 HSP90B1 Mus musculus BHTOH-QM binds to HSP90B1 protein affects^binding 16533022
30 128-37-0 HSPA8 Mus musculus BHTOH-QM binds to HSPA8 protein affects^binding 16533022
31 128-37-0 LGALS1 Mus musculus BHTOH-QM binds to LGALS1 protein affects^binding 16533022
32 128-37-0 PDIA3 Mus musculus BHTOH-QM binds to PDIA3 protein affects^binding 16533022
33 128-37-0 PHGDH Mus musculus BHTOH-QM binds to PHGDH protein affects^binding 16533022
34 128-37-0 PRDX2 Mus musculus BHTOH-QM binds to PRDX2 protein affects^binding 16533022
35 128-37-0 STIP1 Mus musculus BHTOH-QM binds to STIP1 protein affects^binding 16533022
36 128-37-0 TPI1 Mus musculus BHTOH-QM binds to TPI1 protein affects^binding 16533022
37 128-37-0 TPM3 Mus musculus BHTOH-QM binds to TPM3 protein affects^binding 16533022
38 128-37-0 ABCA1 Homo sapiens [Butylated Hydroxytoluene co-treated with iron(II)-ascorbic acid complex] results in increased expression of ABCA1 protein affects^cotreatment|increases^expression 17070507
39 128-37-0 ABCA1 Homo sapiens Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of ABCA1 mRNA] decreases^expression|decreases^reaction 17070507
40 128-37-0 ABCA1 Homo sapiens Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of ABCA1 protein] decreases^expression|decreases^reaction 17070507
41 128-37-0 ABCA1 Homo sapiens Butylated Hydroxytoluene results in increased expression of ABCA1 mRNA increases^expression 17070507
42 128-37-0 ACTA2 Homo sapiens Butylated Hydroxytoluene inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] decreases^reaction|increases^expression 16757516
43 128-37-0 ACTG1 Rattus norvegicus Butylated Hydroxytoluene results in increased expression of ACTG1 mRNA increases^expression 12082028
44 128-37-0 AGT Mus musculus Butylated Hydroxytoluene inhibits the reaction [AGT protein results in increased expression of PSMC6 protein] decreases^reaction|increases^expression 17532611
45 128-37-0 AHR2A Salmo salar Butylated Hydroxytoluene results in increased expression of AHR2A mRNA increases^expression 19007167
46 128-37-0 AKR7A3 Rattus norvegicus Butylated Hydroxytoluene results in increased activity of AKR7A3 protein increases^activity 9328168
47 128-37-0 AKR7A3 Rattus norvegicus Butylated Hydroxytoluene results in increased expression of AKR7A3 protein increases^expression 8198522
48 128-37-0 ALOX15 Oryctolagus cuniculus Butylated Hydroxytoluene analog results in increased activity of ALOX15 protein increases^activity 7811748
49 128-37-0 APOA1 Homo sapiens [Butylated Hydroxytoluene co-treated with Pentetic Acid] inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA1 protein] affects^cotreatment|decreases^reaction|increases^oxidation 12576517
50 128-37-0 APOA2 Homo sapiens [Butylated Hydroxytoluene co-treated with Pentetic Acid] inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA2 protein] affects^cotreatment|decreases^reaction|increases^oxidation 12576517
51 128-37-0 APOA4 Rattus norvegicus Butylated Hydroxytoluene results in increased expression of APOA4 mRNA increases^expression 12082028
52 128-37-0 AR Homo sapiens Butylated Hydroxytoluene inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein] affects^binding|decreases^reaction|increases^activity 10696776
53 128-37-0 ARG1 Mus musculus Butylated Hydroxytoluene results in increased expression of ARG1 mRNA increases^expression 19925653
54 128-37-0 ATP2A1 Rattus norvegicus Butylated Hydroxytoluene inhibits the reaction [[ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein] affects^cotreatment|decreases^activity|decreases^reaction 12870653
55 128-37-0 ATP2A1 Rattus norvegicus Butylated Hydroxytoluene inhibits the reaction [Free Radicals results in decreased activity of ATP2A1 protein] decreases^activity|decreases^reaction 12870653
56 128-37-0 ATP6V1A Homo sapiens Butylated Hydroxytoluene inhibits the reaction [TNF protein results in decreased expression of ATP6V1A protein] decreases^expression|decreases^reaction 12470298
57 128-37-0 ATP6V1A Mus musculus Butylated Hydroxytoluene inhibits the reaction [Reactive Oxygen Species results in decreased expression of ATP6V1A protein] decreases^expression|decreases^reaction 12470298
58 128-37-0 CA2 Homo sapiens Butylated Hydroxytoluene results in decreased activity of CA2 protein decreases^activity 19231207
59 128-37-0 CAPN2 Mus musculus Butylated Hydroxytoluene affects the expression of CAPN2 protein affects^expression 7716780
60 128-37-0 CAPRIN1 Mus musculus Butylated Hydroxytoluene results in increased expression of CAPRIN1 mRNA increases^expression 19925653
61 128-37-0 CASP3 Homo sapiens [Butylated Hydroxyanisole co-treated with Butylated Hydroxytoluene] results in decreased activity of CASP3 protein affects^cotreatment|decreases^activity 14981915
62 128-37-0 CASP3 Homo sapiens Butylated Hydroxytoluene results in decreased activity of CASP3 protein decreases^activity 14981915
63 128-37-0 CASP3 Mus musculus [Butylated Hydroxytoluene co-treated with Oxygen] results in increased cleavage of CASP3 protein affects^cotreatment|increases^cleavage 16272459
64 128-37-0 CASP3 Mus musculus zAsp(Ome)-Arg-His-Asp(Ome)-fluoromethyl ketone inhibits the reaction [[Butylated Hydroxytoluene co-treated with Oxygen] results in increased cleavage of CASP3 protein] affects^cotreatment|decreases^reaction|increases^cleavage 16272459
65 128-37-0 CASP3 Rattus norvegicus Butylated Hydroxytoluene inhibits the reaction [ganglioside, GD3 results in increased cleavage of and results in increased activity of CASP3 protein] decreases^reaction|increases^activity|increases^cleavage 10783138
66 128-37-0 CASP3 Rattus norvegicus Butylated Hydroxytoluene inhibits the reaction [Lithium Carbonate results in increased activity of CASP3 protein] decreases^reaction|increases^activity 27588890
67 128-37-0 CAT Rattus norvegicus Butylated Hydroxytoluene inhibits the reaction [cholestane-3,5,6-triol results in decreased activity of CAT protein] decreases^activity|decreases^reaction 9306888
68 128-37-0 CCDC116 Mus musculus Butylated Hydroxytoluene results in increased expression of CCDC116 mRNA increases^expression 19925653
69 128-37-0 CCL17 Mus musculus Butylated Hydroxytoluene results in increased expression of CCL17 mRNA increases^expression 19925653
70 128-37-0 CCL2 Mus musculus Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of CCL2 protein] decreases^reaction|increases^expression 16822543
71 128-37-0 CCL2 Mus musculus Butylated Hydroxytoluene results in increased expression of CCL2 protein increases^expression 16443645
72 128-37-0 CCL5 Mus musculus Butylated Hydroxytoluene results in decreased expression of CCL5 mRNA decreases^expression 19925653
73 128-37-0 CCNA2 Mus musculus Butylated Hydroxytoluene results in increased expression of CCNA2 mRNA increases^expression 12867420
74 128-37-0 CCNA2 Mus musculus [Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNA2 mRNA increases^expression 12867420
75 128-37-0 CCNB1 Mus musculus Butylated Hydroxytoluene results in increased expression of CCNB1 mRNA increases^expression 12867420|19000923
76 128-37-0 CCNB1 Mus musculus [Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNB1 mRNA increases^expression 12867420
77 128-37-0 CCND1 Mus musculus [Butylated Hydroxytoluene co-treated with Oxygen] results in increased expression of CCND1 protein affects^cotreatment|increases^expression 16272459
78 128-37-0 CCNE1 Mus musculus Butylated Hydroxytoluene results in increased expression of CCNE1 mRNA increases^expression 12867420
79 128-37-0 CCNE1 Mus musculus [Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNE1 mRNA increases^expression 12867420
80 128-37-0 CCNF Mus musculus Butylated Hydroxytoluene results in increased expression of CCNF mRNA increases^expression 12867420
81 128-37-0 CCNF Mus musculus [Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNF mRNA increases^expression 12867420
82 128-37-0 CD19 Mus musculus Butylated Hydroxytoluene results in decreased expression of CD19 mRNA decreases^expression 19925653
83 128-37-0 CD37 Mus musculus Butylated Hydroxytoluene results in decreased expression of CD37 mRNA decreases^expression 19925653
84 128-37-0 CD3D Mus musculus Butylated Hydroxytoluene results in decreased expression of CD3D mRNA decreases^expression 19925653
85 128-37-0 CD44 Mus musculus [Butylated Hydroxytoluene co-treated with Methylcholanthrene] results in increased expression of CD44 mRNA alternative form affects^cotreatment|increases^expression 15390079
86 128-37-0 CD81 Rattus norvegicus Butylated Hydroxytoluene results in increased expression of CD81 mRNA increases^expression 12082028
87 128-37-0 CDH1 Mus musculus [Butylated Hydroxytoluene co-treated with Oxygen] results in decreased expression of CDH1 protein affects^cotreatment|decreases^expression 16272459
88 128-37-0 CDK2AP2 Rattus norvegicus Butylated Hydroxytoluene results in increased expression of CDK2AP2 mRNA increases^expression 12082028
89 128-37-0 CFI Mus musculus Butylated Hydroxytoluene results in increased expression of CFI mRNA increases^expression 19925653
90 128-37-0 CHEK1 Mus musculus Butylated Hydroxytoluene results in increased expression of CHEK1 mRNA increases^expression 19000923
91 128-37-0 CLDN2 Mus musculus Butylated Hydroxytoluene results in increased expression of CLDN2 mRNA increases^expression 19925653
92 128-37-0 COL18A1 Mus musculus Butylated Hydroxytoluene results in increased expression of COL18A1 mRNA increases^expression 19925653
93 128-37-0 COX2 Homo sapiens Butylated Hydroxytoluene inhibits the reaction [TNF protein results in decreased expression of COX2 protein] decreases^expression|decreases^reaction 12470298
94 128-37-0 COX2 Mus musculus Butylated Hydroxytoluene inhibits the reaction [Reactive Oxygen Species results in decreased expression of COX2 protein] decreases^expression|decreases^reaction 12470298
95 128-37-0 COX6B2 Mus musculus Butylated Hydroxytoluene results in increased expression of COX6B2 mRNA increases^expression 19925653
96 128-37-0 CSF2 Mus musculus Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of CSF2 protein] decreases^reaction|increases^expression 16822543
97 128-37-0 CTNNB1 Mus musculus [Butylated Hydroxytoluene co-treated with Oxygen] affects the localization of CTNNB1 protein affects^cotreatment|affects^localization 16272459
98 128-37-0 CTNNB1 Mus musculus [Butylated Hydroxytoluene co-treated with Oxygen] results in increased expression of CTNNB1 protein affects^cotreatment|increases^expression 16272459
99 128-37-0 CYP1A Phasianidae Butylated Hydroxytoluene results in decreased activity of CYP1A protein decreases^activity 12659720
100 128-37-0 CYP1A Salmo salar Butylated Hydroxytoluene affects the expression of CYP1A mRNA affects^expression 19007167
101 128-37-0 CYP1A1 Meleagris gallopavo Butylated Hydroxytoluene results in decreased activity of CYP1A1 protein decreases^activity 18177683
102 128-37-0 CYP1A1 Mus musculus Butylated Hydroxytoluene affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA] affects^reaction|increases^expression 21094198
103 128-37-0 CYP1A1 Mus musculus Butylated Hydroxytoluene results in increased expression of CYP1A1 mRNA increases^expression 19925653
104 128-37-0 CYP1A2 Meleagris gallopavo Butylated Hydroxytoluene results in decreased activity of CYP1A2 protein decreases^activity 18177683
105 128-37-0 CYP2B1 Rattus norvegicus Butylated Hydroxytoluene results in increased expression of CYP2B1 mRNA increases^expression 15110098
106 128-37-0 CYP2B1 Rattus norvegicus Butylated Hydroxytoluene results in increased expression of CYP2B1 protein increases^expression 15110098
107 128-37-0 CYP2B2 Rattus norvegicus Butylated Hydroxytoluene results in increased expression of CYP2B2 mRNA increases^expression 12082028|15110098|18539377
108 128-37-0 CYP2B2 Rattus norvegicus Butylated Hydroxytoluene results in increased expression of CYP2B2 protein increases^expression 15110098
109 128-37-0 CYP2B4 Oryctolagus cuniculus Butylated Hydroxytoluene binds to CYP2B4 protein affects^binding 18311926
110 128-37-0 CYP2B4 Oryctolagus cuniculus CYP2B4 protein binds to and results in increased metabolism of Butylated Hydroxytoluene affects^binding|increases^metabolic processing 18700729
111 128-37-0 CYP2B6 Homo sapiens Butylated Hydroxytoluene results in increased expression of CYP2B6 mRNA increases^expression 18570159
112 128-37-0 CYP2C39 Rattus norvegicus Butylated Hydroxytoluene results in increased expression of CYP2C39 mRNA increases^expression 12082028
113 128-37-0 CYP2C6V1 Rattus norvegicus Butylated Hydroxytoluene results in increased expression of CYP2C6V1 mRNA increases^expression 18539377
114 128-37-0 CYP2J2 Homo sapiens Butylated Hydroxytoluene results in increased expression of CYP2J2 mRNA increases^expression 24021950
115 128-37-0 CYP3A Salmo salar Butylated Hydroxytoluene affects the expression of CYP3A protein affects^expression 19007167
116 128-37-0 CYP3A4 Homo sapiens Butylated Hydroxytoluene results in increased expression of CYP3A4 mRNA increases^expression 18570159
117 128-37-0 CYP3A4 Meleagris gallopavo Butylated Hydroxytoluene affects the activity of CYP3A4 protein affects^activity 18177683
118 128-37-0 CYP3A9 Rattus norvegicus Butylated Hydroxytoluene results in increased expression of CYP3A9 mRNA increases^expression 18539377
119 128-37-0 DCX Rattus norvegicus Butylated Hydroxytoluene inhibits the reaction [Ethanol results in decreased expression of DCX protein] decreases^expression|decreases^reaction 17067360
120 128-37-0 DNAJC3 Mus musculus Butylated Hydroxytoluene results in increased expression of DNAJC3 mRNA increases^expression 19925653
121 128-37-0 DOCK2 Mus musculus Butylated Hydroxytoluene results in decreased expression of DOCK2 mRNA decreases^expression 19925653
122 128-37-0 ELN Mus musculus [Oxygen co-treated with Butylated Hydroxytoluene] results in increased expression of ELN mRNA affects^cotreatment|increases^expression 10761639
123 128-37-0 EPOR Mus musculus Butylated Hydroxytoluene results in increased expression of EPOR mRNA increases^expression 19925653
124 128-37-0 EREG Mus musculus Butylated Hydroxytoluene results in increased expression of EREG mRNA increases^expression 19925653
125 128-37-0 EVPL Mus musculus Butylated Hydroxytoluene results in increased expression of EVPL mRNA increases^expression 19925653
126 128-37-0 F3 Homo sapiens Butylated Hydroxytoluene inhibits the reaction [Copper results in increased activity of F3 protein] decreases^reaction|increases^activity 7600656
127 128-37-0 FOSL1 Mus musculus Butylated Hydroxytoluene results in increased expression of FOSL1 mRNA increases^expression 19000923|19925653
128 128-37-0 FOXF1 Mus musculus Butylated Hydroxytoluene results in decreased expression of FOXF1 mRNA decreases^expression 11238010
129 128-37-0 FOXM1 Mus musculus Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA increases^expression 11238010|12867420
130 128-37-0 FOXM1 Mus musculus Butylated Hydroxytoluene results in increased expression of FOXM1 protein increases^expression 11238010
131 128-37-0 FOXM1 Mus musculus FOXM1 protein affects the susceptibility to Butylated Hydroxytoluene affects^response to substance 18345025|19672312
132 128-37-0 GCLC Mus musculus Butylated Hydroxytoluene results in increased expression of GCLC protein increases^expression 21536018
133 128-37-0 GCLC Sus scrofa Butylated Hydroxytoluene results in increased expression of GCLC mRNA increases^expression 9535746
134 128-37-0 GFPT2 Mus musculus Butylated Hydroxytoluene results in increased expression of GFPT2 mRNA increases^expression 19925653
135 128-37-0 GGTA1 Mus musculus Butylated Hydroxytoluene results in increased expression of GGTA1 mRNA increases^expression 19925653
136 128-37-0 GNMT Rattus norvegicus Butylated Hydroxytoluene results in increased expression of GNMT mRNA increases^expression 12082028
137 128-37-0 GPLD1 Rattus norvegicus Butylated Hydroxytoluene results in increased expression of GPLD1 mRNA increases^expression 12082028
138 128-37-0 GSTA3 Phasianidae Butylated Hydroxytoluene results in increased expression of GSTA3 protein increases^expression 12659720
139 128-37-0 GSTA5 Phasianidae Butylated Hydroxytoluene results in increased expression of GSTA5 protein increases^expression 12659720
140 128-37-0 GSTA5 Rattus norvegicus Butylated Hydroxytoluene results in increased activity of GSTA5 protein increases^activity 9328168
141 128-37-0 GSTA5 Rattus norvegicus Butylated Hydroxytoluene results in increased expression of and results in increased activity of GSTA5 protein increases^activity|increases^expression 8198522
142 128-37-0 GSTM2 Rattus norvegicus Butylated Hydroxytoluene results in increased expression of GSTM2 mRNA increases^expression 12082028|18539377
143 128-37-0 GSTP1 Mus musculus Butylated Hydroxytoluene results in increased alkylation of and results in decreased activity of GSTP1 protein decreases^activity|increases^alkylation 21536018
144 128-37-0 GSTP1 Rattus norvegicus Butylated Hydroxytoluene results in increased expression of GSTP1 mRNA increases^expression 15110098
145 128-37-0 GSTS1 Salmo salar Butylated Hydroxytoluene affects the expression of GSTS1 mRNA affects^expression 19007167
146 128-37-0 GSTT1 Rattus norvegicus Butylated Hydroxytoluene results in increased expression of GSTT1 mRNA increases^expression 15110098
147 128-37-0 GZMA Mus musculus Butylated Hydroxytoluene results in decreased expression of GZMA mRNA decreases^expression 19925653
148 128-37-0 HC Rattus norvegicus Butylated Hydroxytoluene results in increased expression of HC mRNA increases^expression 12082028
149 128-37-0 HCK Rattus norvegicus Butylated Hydroxytoluene affects the expression of HCK mRNA affects^expression 18539377
150 128-37-0 HELLS Mus musculus Butylated Hydroxytoluene results in increased expression of HELLS mRNA increases^expression 19000923
151 128-37-0 HMGCR Rattus norvegicus Butylated Hydroxytoluene results in increased activity of HMGCR protein increases^activity 9199277
152 128-37-0 HMOX1 Homo sapiens Butylated Hydroxytoluene affects the expression of HMOX1 mRNA affects^expression 8743975
153 128-37-0 HMOX1 Rattus norvegicus Butylated Hydroxytoluene results in increased expression of HMOX1 mRNA increases^expression 12420312
154 128-37-0 HNF1A Mus musculus [Butylated Hydroxytoluene co-treated with Oxygen] results in increased expression of HNF1A mRNA affects^cotreatment|increases^expression 16272459
155 128-37-0 HNRNPA1 Mus musculus [Butylated Hydroxytoluene co-treated with Methylcholanthrene] affects the localization of HNRNPA1 protein affects^cotreatment|affects^localization 15390079
156 128-37-0 HNRNPA1 Mus musculus [Butylated Hydroxytoluene co-treated with Methylcholanthrene] results in increased expression of HNRNPA1 protein affects^cotreatment|increases^expression 15390079
157 128-37-0 HNRNPA1 Mus musculus Butylated Hydroxytoluene results in increased expression of HNRNPA1 protein increases^expression 15390079
158 128-37-0 HNRNPA2B1 Mus musculus [Methylcholanthrene co-treated with Butylated Hydroxytoluene] affects the expression of HNRNPA2B1 protein affects^cotreatment|affects^expression 17477362
159 128-37-0 HRAS Mus musculus HRAS protein results in increased susceptibility to Butylated Hydroxytoluene increases^response to substance 11599794
160 128-37-0 HSPA9 Mus musculus Butylated Hydroxytoluene results in increased expression of HSPA9 mRNA increases^expression 19925653
161 128-37-0 IL10 Mus musculus Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in decreased expression of IL10 protein] decreases^expression|decreases^reaction 16822543
162 128-37-0 IL15 Rattus norvegicus Butylated Hydroxytoluene affects the expression of IL15 mRNA affects^expression 18539377
163 128-37-0 IL1A Mus musculus Butylated Hydroxytoluene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1A mRNA] decreases^reaction|increases^expression 8435107
164 128-37-0 IL1RL1 Mus musculus Butylated Hydroxytoluene results in increased expression of IL1RL1 mRNA increases^expression 19000923
165 128-37-0 IL2 Mus musculus Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of IL2 protein] decreases^reaction|increases^expression 16822543
166 128-37-0 IL4 Mus musculus Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of IL4 protein] decreases^reaction|increases^expression 16822543
167 128-37-0 ILK Mus musculus [Butylated Hydroxytoluene co-treated with Oxygen] results in increased expression of ILK protein affects^cotreatment|increases^expression 16272459
168 128-37-0 JUNB Mus musculus Butylated Hydroxytoluene results in increased expression of JUNB mRNA increases^expression 19000923
169 128-37-0 KNG1 Mus musculus Butylated Hydroxytoluene results in increased expression of KNG1 mRNA increases^expression 19925653
170 128-37-0 KRAS Mus musculus Butylated Hydroxytoluene results in increased mutagenesis of KRAS gene increases^mutagenesis 20101149
171 128-37-0 LEF1 Mus musculus [Butylated Hydroxytoluene co-treated with Oxygen] results in increased expression of LEF1 mRNA affects^cotreatment|increases^expression 16272459
172 128-37-0 LEP Mus musculus Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein] decreases^reaction|increases^expression 16822543
173 128-37-0 LPA Homo sapiens Butylated Hydroxytoluene inhibits the reaction [LPA protein modified form results in decreased expression of PLAT protein] decreases^expression|decreases^reaction 10856522
174 128-37-0 LPA Homo sapiens Butylated Hydroxytoluene inhibits the reaction [LPA protein modified form results in increased expression of PLAT protein] decreases^reaction|increases^expression 10856522
175 128-37-0 LPA Homo sapiens Butylated Hydroxytoluene inhibits the reaction [LPA protein results in decreased expression of SERPINE1 protein] decreases^expression|decreases^reaction 10856522
176 128-37-0 LPA Homo sapiens Butylated Hydroxytoluene inhibits the reaction [LPA protein results in increased expression of SERPINE1 protein] decreases^reaction|increases^expression 10856522
177 128-37-0 MAPK1 Oryctolagus cuniculus Butylated Hydroxytoluene inhibits the reaction [Tyramine results in increased activity of MAPK1 protein] decreases^reaction|increases^activity 17561096
178 128-37-0 MAPK14 Mus musculus Butylated Hydroxytoluene results in increased expression of MAPK14 mRNA increases^expression 19925653
179 128-37-0 MBP Mus musculus Butylated Hydroxytoluene results in increased expression of MBP mRNA increases^expression 19925653
180 128-37-0 MCM3 Mus musculus Butylated Hydroxytoluene results in increased expression of MCM3 mRNA increases^expression 19000923
181 128-37-0 MSH6 Danio rerio Butylated Hydroxytoluene inhibits the reaction [Cadmium results in decreased expression of MSH6 mRNA] decreases^expression|decreases^reaction 23143036
182 128-37-0 MYL3 Mus musculus Butylated Hydroxytoluene results in increased expression of MYL3 mRNA increases^expression 19925653
183 128-37-0 NFE2L2 Mus musculus NFE2L2 protein results in decreased susceptibility to Butylated Hydroxytoluene decreases^response to substance 10535991
184 128-37-0 NFKB1 Rattus norvegicus Butylated Hydroxytoluene inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] decreases^reaction|increases^activity 15713255
185 128-37-0 NGF Rattus norvegicus Butylated Hydroxytoluene inhibits the reaction [Streptozocin results in increased expression of NGF mRNA] decreases^reaction|increases^expression 9748608
186 128-37-0 NQO1 Phasianidae Butylated Hydroxytoluene results in increased activity of NQO1 protein increases^activity 12659720
187 128-37-0 NQO1 Rattus norvegicus Butylated Hydroxytoluene results in increased expression of NQO1 mRNA increases^expression 20308224
188 128-37-0 NR1H2 Homo sapiens Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of NR1H2 mRNA] decreases^expression|decreases^reaction 17070507
189 128-37-0 NR1H3 Homo sapiens Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of NR1H3 mRNA] decreases^expression|decreases^reaction 17070507
190 128-37-0 NR1I3 Homo sapiens Butylated Hydroxytoluene binds to and results in decreased activity of NR1I3 protein alternative form affects^binding|decreases^activity 20869355
191 128-37-0 NR1I3 Homo sapiens Butylated Hydroxytoluene binds to and results in increased activity of NR1I3 protein alternative form affects^binding|increases^activity 20869355
192 128-37-0 NRAS Rattus norvegicus Butylated Hydroxytoluene results in increased activity of NRAS increases^activity 3040652
193 128-37-0 NRBF2 Rattus norvegicus Butylated Hydroxytoluene results in increased expression of NRBF2 mRNA increases^expression 12082028
194 128-37-0 NUP54 Mus musculus Butylated Hydroxytoluene results in increased expression of NUP54 mRNA increases^expression 19000923
195 128-37-0 OGG1 Homo sapiens Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of OGG1 mRNA] decreases^expression|decreases^reaction 20676402
196 128-37-0 PARN Mus musculus Butylated Hydroxytoluene results in decreased expression of PARN mRNA decreases^expression 19925653
197 128-37-0 PARP1 Homo sapiens Butylated Hydroxytoluene inhibits the reaction [Benzoyl Peroxide results in increased activity of PARP1 protein] decreases^reaction|increases^activity 2126186
198 128-37-0 PARP1 Homo sapiens Butylated Hydroxytoluene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of PARP1 protein] decreases^reaction|increases^activity 2126186
199 128-37-0 PCNA Mus musculus Butylated Hydroxytoluene results in increased expression of PCNA protein increases^expression 11238010
200 128-37-0 PER2 Mus musculus Butylated Hydroxytoluene results in increased expression of PER2 mRNA increases^expression 19925653
201 128-37-0 PGK1 Homo sapiens Butylated Hydroxytoluene inhibits the reaction [Hydrogen Peroxide results in increased expression of PGK1 protein] decreases^reaction|increases^expression 18603805
202 128-37-0 PHEX Mus musculus Butylated Hydroxytoluene results in increased expression of PHEX mRNA increases^expression 19000923
203 128-37-0 PIK3R5 Mus musculus Butylated Hydroxytoluene results in increased expression of PIK3R5 mRNA increases^expression 19000923
204 128-37-0 PKNOX2 Mus musculus Butylated Hydroxytoluene results in increased expression of PKNOX2 mRNA increases^expression 19925653
205 128-37-0 PLA2G4A Mus musculus Butylated Hydroxytoluene results in increased expression of PLA2G4A protein increases^expression 16443645
206 128-37-0 PNPLA8 Oryctolagus cuniculus Butylated Hydroxytoluene inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of PNPLA8 protein] decreases^activity|decreases^reaction 15153555
207 128-37-0 POMP Rattus norvegicus Butylated Hydroxytoluene results in increased expression of POMP mRNA increases^expression 12082028
208 128-37-0 PON1 Homo sapiens Butylated Hydroxytoluene inhibits the reaction [[Iron co-treated with Ascorbic Acid] results in decreased expression of PON1 protein] affects^cotreatment|decreases^expression|decreases^reaction 16052486
209 128-37-0 PON2 Homo sapiens Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of PON2 protein] decreases^reaction|increases^expression 17916643
210 128-37-0 POU2F1 Mus musculus Butylated Hydroxytoluene results in decreased expression of POU2F1 mRNA decreases^expression 19925653
211 128-37-0 PPAR Homo sapiens Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of PPAR mRNA] decreases^expression|decreases^reaction 17070507
212 128-37-0 PPARG Homo sapiens Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of PPARG mRNA] decreases^expression|decreases^reaction 17070507
213 128-37-0 PPARG Mus musculus Butylated Hydroxytoluene results in increased expression of PPARG mRNA increases^expression 19925653
214 128-37-0 PRKCA Mus musculus Butylated Hydroxytoluene results in decreased expression of PRKCA protein decreases^expression 7716780
215 128-37-0 PRL2C3 Mus musculus Butylated Hydroxytoluene results in increased expression of PRL2C3 mRNA increases^expression 19000923
216 128-37-0 PSMC6 Homo sapiens Butylated Hydroxytoluene inhibits the reaction [TNF protein results in decreased expression of PSMC6 mRNA] decreases^expression|decreases^reaction 12470298
217 128-37-0 PSMC6 Mus musculus Butylated Hydroxytoluene inhibits the reaction [Reactive Oxygen Species results in decreased expression of PSMC6 mRNA] decreases^expression|decreases^reaction 12470298
218 128-37-0 PTGS1 Mus musculus Butylated Hydroxytoluene results in increased expression of PTGS1 protein increases^expression 11696405
219 128-37-0 PTGS1 Ovis aries Butylated Hydroxytoluene analog results in decreased activity of PTGS1 protein decreases^activity 16690318
220 128-37-0 PTGS2 Mus musculus Butylated Hydroxytoluene results in increased expression of PTGS2 protein increases^expression 11696405
221 128-37-0 PTGS2 Rattus norvegicus Butylated Hydroxytoluene inhibits the reaction [Ethanol results in increased expression of PTGS2 mRNA] decreases^reaction|increases^expression 17067360
222 128-37-0 PTHLH Mus musculus Butylated Hydroxytoluene results in increased expression of PTHLH mRNA increases^expression 19925653
223 128-37-0 RAB31 Mus musculus Butylated Hydroxytoluene results in decreased expression of RAB31 mRNA decreases^expression 19925653
224 128-37-0 RAD21 Mus musculus Butylated Hydroxytoluene results in increased expression of RAD21 mRNA increases^expression 19000923
225 128-37-0 RAD51AP1 Mus musculus Butylated Hydroxytoluene results in increased expression of RAD51AP1 mRNA increases^expression 19000923
226 128-37-0 RELA Rattus norvegicus Butylated Hydroxytoluene inhibits the reaction [Cadmium Chloride results in decreased activity of RELA protein] decreases^activity|decreases^reaction 16478757
227 128-37-0 RELA Rattus norvegicus Butylated Hydroxytoluene inhibits the reaction [Cadmium results in decreased activity of RELA protein] decreases^activity|decreases^reaction 16478757
228 128-37-0 RELA Rattus norvegicus Butylated Hydroxytoluene inhibits the reaction [TNF protein results in increased activity of RELA protein] decreases^reaction|increases^activity 15713255
229 128-37-0 RIF1 Mus musculus Butylated Hydroxytoluene results in increased expression of RIF1 mRNA increases^expression 19000923
230 128-37-0 RNF112 Rattus norvegicus Butylated Hydroxytoluene affects the expression of RNF112 mRNA affects^expression 18539377
231 128-37-0 SELL Mus musculus Butylated Hydroxytoluene results in decreased expression of SELL mRNA decreases^expression 19925653
232 128-37-0 SERPINH1 Mus musculus Butylated Hydroxytoluene results in increased expression of SERPINH1 mRNA increases^expression 19925653
233 128-37-0 SHISA2 Mus musculus Butylated Hydroxytoluene results in decreased expression of SHISA2 mRNA decreases^expression 19925653
234 128-37-0 SLC2A1 Mus musculus Butylated Hydroxytoluene results in increased expression of SLC2A1 mRNA increases^expression 19000923
235 128-37-0 SLC2A3 Mus musculus Butylated Hydroxytoluene results in decreased expression of SLC2A3 mRNA decreases^expression 19925653
236 128-37-0 SLC39A11 Mus musculus Butylated Hydroxytoluene results in increased expression of SLC39A11 mRNA increases^expression 19925653
237 128-37-0 SLFN4 Mus musculus Butylated Hydroxytoluene results in decreased expression of SLFN4 mRNA decreases^expression 19925653
238 128-37-0 SMPD3 Oryctolagus cuniculus Butylated Hydroxytoluene inhibits the reaction [Tyramine results in increased activity of SMPD3 protein] decreases^reaction|increases^activity 17561096
239 128-37-0 SOD2 Homo sapiens [Butylated Hydroxyanisole co-treated with Butylated Hydroxytoluene] results in decreased expression of SOD2 mRNA affects^cotreatment|decreases^expression 14981915
240 128-37-0 SPIB Mus musculus Butylated Hydroxytoluene results in decreased expression of SPIB mRNA decreases^expression 19925653
241 128-37-0 SPP1 Mus musculus Butylated Hydroxytoluene results in increased expression of SPP1 mRNA increases^expression 19925653
242 128-37-0 SRSF1 Mus musculus [Butylated Hydroxytoluene co-treated with Methylcholanthrene] affects the localization of SRSF1 protein affects^cotreatment|affects^localization 15390079
243 128-37-0 SRSF1 Mus musculus [Butylated Hydroxytoluene co-treated with Methylcholanthrene] results in increased expression of SRSF1 protein affects^cotreatment|increases^expression 15390079
244 128-37-0 SRSF1 Mus musculus Butylated Hydroxytoluene results in increased expression of SRSF1 protein increases^expression 15390079
245 128-37-0 STMN1 Mus musculus Butylated Hydroxytoluene results in increased expression of STMN1 mRNA increases^expression 19000923
246 128-37-0 STOM Mus musculus Butylated Hydroxytoluene results in increased expression of STOM mRNA increases^expression 19925653
247 128-37-0 TAC1 Rattus norvegicus Butylated Hydroxytoluene inhibits the reaction [Streptozocin results in increased expression of TAC1 mRNA] decreases^reaction|increases^expression 9748608
248 128-37-0 TDO2 Mus musculus Butylated Hydroxytoluene results in increased expression of TDO2 mRNA increases^expression 19925653
249 128-37-0 TDO2 Rattus norvegicus Butylated Hydroxytoluene affects the expression of TDO2 mRNA affects^expression 18539377
250 128-37-0 TFAM Homo sapiens Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of TFAM mRNA] decreases^reaction|increases^expression 20676402
251 128-37-0 TFAM Homo sapiens Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of TFAM protein] decreases^reaction|increases^expression 20676402
252 128-37-0 TFB1M Homo sapiens Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of TFB1M mRNA] decreases^reaction|increases^expression 20676402
253 128-37-0 TFB1M Homo sapiens Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of TFB1M protein] decreases^reaction|increases^expression 20676402
254 128-37-0 TFB2M Homo sapiens Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of TFB2M mRNA] decreases^reaction|increases^expression 20676402
255 128-37-0 TFB2M Homo sapiens Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of TFB2M protein] decreases^reaction|increases^expression 20676402
256 128-37-0 TFRC Mus musculus Butylated Hydroxytoluene results in increased expression of TFRC mRNA increases^expression 19000923
257 128-37-0 TGFA Rattus norvegicus Butylated Hydroxytoluene results in decreased susceptibility to TGFA protein decreases^response to substance 7593635
258 128-37-0 THPO Mus musculus Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of THPO protein] decreases^reaction|increases^expression 16822543
259 128-37-0 TMEM45B Mus musculus Butylated Hydroxytoluene results in decreased expression of TMEM45B mRNA decreases^expression 19925653
260 128-37-0 TNC Mus musculus Butylated Hydroxytoluene results in increased expression of TNC mRNA increases^expression 19925653
261 128-37-0 TNF Homo sapiens Butylated Hydroxytoluene inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] decreases^reaction|increases^expression 9721806
262 128-37-0 TNF Homo sapiens Butylated Hydroxytoluene inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] decreases^reaction|increases^expression 9721806
263 128-37-0 TNF Homo sapiens Butylated Hydroxytoluene results in decreased expression of TNF protein decreases^expression 9721806
264 128-37-0 TNF Homo sapiens Butylated Hydroxytoluene results in increased susceptibility to TNF protein increases^response to substance 16910777
265 128-37-0 TNF Mus musculus Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of TNF protein] decreases^reaction|increases^expression 16822543
266 128-37-0 TP53 Rattus norvegicus Butylated Hydroxytoluene results in increased expression of TP53 mRNA increases^expression 9780227
267 128-37-0 TTR Rattus norvegicus Butylated Hydroxytoluene results in increased expression of TTR mRNA increases^expression 12082028
268 128-37-0 UBE2G2 Mus musculus Butylated Hydroxytoluene results in increased expression of UBE2G2 mRNA increases^expression 19925653
269 128-37-0 UGT Salmo salar Butylated Hydroxytoluene affects the expression of UGT mRNA affects^expression 19007167
270 128-37-0 VEGFA Mus musculus Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of VEGFA protein] decreases^reaction|increases^expression 16822543
271 128-37-0 VEGFA Mus musculus Butylated Hydroxytoluene results in increased expression of VEGFA mRNA increases^expression 19000923
272 128-37-0 PPARG Homo sapiens Irganox 1010 binds to and results in decreased activity of PPARG protein affects^binding|decreases^activity 27633901
273 128-37-0 PPARG Homo sapiens Irganox 1010 binds to and results in increased activity of PPARG protein affects^binding|increases^activity 27633901
274 128-37-0 THRB Homo sapiens Irganox 1010 binds to and results in decreased activity of THRB protein affects^binding|decreases^activity 27633901
275 128-37-0 CLU Rattus norvegicus LY 231617 affects the expression of CLU mRNA affects^expression 8915593
276 128-37-0 GFAP Rattus norvegicus LY 231617 affects the expression of GFAP mRNA affects^expression 8915593
277 128-37-0 ESR1 Homo sapiens Santowhite powder binds to ESR1 protein affects^binding 16231125
278 128-37-0 ESR1 Homo sapiens Santowhite powder inhibits the reaction [Estradiol binds to ESR1 protein] affects^binding|decreases^reaction 16231125
Serial No.Activity Name DetailsReferences (PubMed)Other details EPA (U.S)Clinical Trials (U.S. NIH)
1 128-37-0 Dibunol

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