AromaDb: A Database of Plant's Aroma Molecules

4-Pyridinamine Details

: IUPAC Name
pyridin-4-amine
:Chemical Class
:CAS Registry Number
504-24-5
:Description

:Fragrance Type

Physical and Chemical properties

PUBCHEM ID1727
Molecular Weight (mg/mol)94.1145
Molecular FormulaC5H6N2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count0
IUPAC Namepyridin-4-amine
Canonical SMILESNc1ccncc1
PUBCHEM IUPAC INCHIKEYNUKYPUAOHBNCPY-UHFFFAOYSA-N
Solubility Level4
Vapour Pressure-1.277

Absorption and Metabolism information

XLOGP3 AA
CACTVS TPSA38.9
BBB Level3
Absorption Level0
EXT PPB#Prediction0
AlogP98-0.068
EXT CYP2D6#Prediction0

Toxicological Information

Mouse Female FDASingle-Carcinogen
Mouse Male FDASingle-Carcinogen
Rat Female FDAMulti-Carcinogen
Rat Male FDAMulti-Carcinogen
Ames PredictionMutagen
Developmental / Reproductive ToxicityNon-Toxic
Rat Oral LD500.356592 g/kg_body_weight
Ocular IrritancyModerate
Hepatotoxic#Prediction1
Effected Human Genes

Ecological Information

Aerobic Biodegradability PredictionNon-Degradable

Hazard(s) Identification

Physical hazardsnot classified
Health hazards None
Environmental hazardsnot classified
About Table Headings

Compound Biological Activity

Serial No.Cas No Gene SymbolOrganismInteraction Interaction ActionsPubMed Id
1 504-24-5 ALK Homo sapiens 2,4-diaminopyridine analog binds to and results in decreased activity of ALK protein affects^binding|decreases^activity 22564207
2 504-24-5 ADRA1B Rattus norvegicus 4-Aminopyridine inhibits the reaction [ADRA1B protein results in increased susceptibility to Phenylephrine] decreases^reaction|increases^response to substance 18480251
3 504-24-5 BAX Rattus norvegicus 4-Aminopyridine results in increased expression of BAX mRNA increases^expression 24378259
4 504-24-5 BIRC2 Rattus norvegicus 4-Aminopyridine results in decreased expression of BIRC2 mRNA decreases^expression 24378259
5 504-24-5 BIRC3 Rattus norvegicus 4-Aminopyridine results in decreased expression of BIRC3 mRNA decreases^expression 24378259
6 504-24-5 BMF Rattus norvegicus 4-Aminopyridine results in increased expression of BMF mRNA increases^expression 24378259
7 504-24-5 C1ORF159 Rattus norvegicus 4-Aminopyridine results in increased expression of C1ORF159 mRNA increases^expression 24378259
8 504-24-5 CASP3 Rattus norvegicus 4-Aminopyridine results in increased activity of CASP3 protein increases^activity 24378259
9 504-24-5 CASP7 Rattus norvegicus 4-Aminopyridine results in increased activity of CASP7 protein increases^activity 24378259
10 504-24-5 CASP9 Rattus norvegicus 4-Aminopyridine results in increased activity of CASP9 protein increases^activity 24378259
11 504-24-5 CD40 Rattus norvegicus 4-Aminopyridine results in increased expression of CD40 mRNA increases^expression 24378259
12 504-24-5 CD40LG Rattus norvegicus 4-Aminopyridine results in increased expression of CD40LG mRNA increases^expression 24378259
13 504-24-5 CTSB Rattus norvegicus 4-Aminopyridine results in increased expression of CTSB mRNA increases^expression 24378259
14 504-24-5 DPYSL4 Rattus norvegicus 4-Aminopyridine results in increased expression of DPYSL4 mRNA increases^expression 24378259
15 504-24-5 GAD2 Rattus norvegicus 4-Aminopyridine results in increased expression of GAD2 mRNA increases^expression 25917026
16 504-24-5 GAD2 Rattus norvegicus KCNIP1 mRNA promotes the reaction [4-Aminopyridine results in increased expression of GAD2 mRNA] increases^expression|increases^reaction 25917026
17 504-24-5 GALNT5 Rattus norvegicus 4-Aminopyridine results in decreased expression of GALNT5 mRNA decreases^expression 24378259
18 504-24-5 GRIN2D Mus musculus [Bicuculline co-treated with 4-Aminopyridine] results in decreased expression of GRIN2D protein affects^cotreatment|decreases^expression 19911010
19 504-24-5 HDAC5 Rattus norvegicus [Bicuculline co-treated with 4-Aminopyridine] affects the localization of HDAC5 protein affects^cotreatment|affects^localization 15773917
20 504-24-5 JPH3 Rattus norvegicus 4-Aminopyridine results in increased expression of JPH3 mRNA increases^expression 24378259
21 504-24-5 KCNA5 4-Aminopyridine results in decreased activity of KCNA5 protein decreases^activity 23261645
22 504-24-5 KCND3 Rattus norvegicus 4-Aminopyridine results in increased expression of KCND3 mRNA increases^expression 25917026
23 504-24-5 KCND3 Rattus norvegicus KCNIP1 mRNA promotes the reaction [4-Aminopyridine results in increased expression of KCND3 mRNA] increases^expression|increases^reaction 25917026
24 504-24-5 KCNH2 Homo sapiens 4-Aminopyridine results in decreased activity of KCNH2 protein decreases^activity 19915712
25 504-24-5 KCNIP1 Rattus norvegicus 4-Aminopyridine results in decreased expression of KCNIP1 mRNA decreases^expression 24378259
26 504-24-5 KCNIP1 Rattus norvegicus 4-Aminopyridine results in increased expression of KCNIP1 mRNA increases^expression 25917026
27 504-24-5 MAG Rattus norvegicus 4-Aminopyridine results in decreased expression of MAG mRNA decreases^expression 24378259
28 504-24-5 MAP1LC3A Rattus norvegicus 4-Aminopyridine results in increased expression of MAP1LC3A mRNA increases^expression 24378259
29 504-24-5 MAPK1 Mus musculus [Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK1 protein affects^cotreatment|increases^activity|increases^phosphorylation 19911010
30 504-24-5 MAPK1 Mus musculus Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK1 protein] affects^cotreatment|decreases^reaction|increases^activity|increases^phosphorylation 19911010
31 504-24-5 MAPK3 Mus musculus [Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK3 protein affects^cotreatment|increases^activity|increases^phosphorylation 19911010
32 504-24-5 MAPK3 Mus musculus Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK3 protein] affects^cotreatment|decreases^reaction|increases^activity|increases^phosphorylation 19911010
33 504-24-5 NCOR2 Rattus norvegicus 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein] affects^cotreatment|affects^localization|decreases^reaction 15773917
34 504-24-5 NCOR2 Rattus norvegicus [Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein affects^cotreatment|affects^localization 15773917
35 504-24-5 NCOR2 Rattus norvegicus KN 62 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein] affects^cotreatment|affects^localization|decreases^reaction 15773917
36 504-24-5 NCOR2 Rattus norvegicus STO 609 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein] affects^cotreatment|affects^localization|decreases^reaction 15773917
37 504-24-5 OLR1583 Rattus norvegicus 4-Aminopyridine results in decreased expression of OLR1583 mRNA decreases^expression 24378259
38 504-24-5 PLAT [Bicuculline co-treated with 4-Aminopyridine co-treated with Dizocilpine Maleate] results in decreased susceptibility to PLAT protein affects^cotreatment|decreases^response to substance 19911010
39 504-24-5 RARA Rattus norvegicus [Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein] affects^cotreatment|increases^activity|increases^reaction 15773917
40 504-24-5 RARA Rattus norvegicus Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]] affects^cotreatment|decreases^reaction|increases^activity|increases^reaction 15773917
41 504-24-5 RARA Rattus norvegicus KN 62 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]] affects^cotreatment|decreases^reaction|increases^activity|increases^reaction 15773917
42 504-24-5 RARA Rattus norvegicus STO 609 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]] affects^cotreatment|decreases^reaction|increases^activity|increases^reaction 15773917
43 504-24-5 S100A7A Rattus norvegicus 4-Aminopyridine results in decreased expression of S100A7A mRNA decreases^expression 24378259
44 504-24-5 SYN1 Mus musculus SYN1 protein affects the susceptibility to 4-Aminopyridine affects^response to substance 22759588
45 504-24-5 SYN1 Mus musculus SYN1 results in increased susceptibility to 4-Aminopyridine increases^response to substance 28132918
46 504-24-5 SYN1 Rattus norvegicus 4-Aminopyridine results in increased expression of SYN1 protein modified form increases^expression 28132918
47 504-24-5 SYN1 Rattus norvegicus ciproxifan inhibits the reaction [4-Aminopyridine results in increased expression of SYN1 protein modified form] decreases^reaction|increases^expression 28132918
48 504-24-5 TRAF2 Rattus norvegicus 4-Aminopyridine results in increased expression of TRAF2 mRNA increases^expression 24378259
Serial No.Activity Name DetailsReferences (PubMed)Other details EPA (U.S)Clinical Trials (U.S. NIH)
1 504-24-5 4-Pyridinamine

Plant Variety and Essential oils

Serial No.Plant NameVariety NameEssential OilCompound Percentage
1 Mulethi Mishri Glucyrrhiza glabra mulethi essential oil

Compound Image


2D Structure

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