AromaDb: A Database of Plant's Aroma Molecules

wortmannin Details

: IUPAC Name
NA
:Chemical Class
:CAS Registry Number
19545-26-7
:Description

:Fragrance Type

Physical and Chemical properties

PUBCHEM ID312145
Molecular Weight (mg/mol)428.432
Molecular FormulaC23H24O8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
IUPAC Name
Canonical SMILESCOCC3OC(=O)c4coc5C(=O)/C1=C(C(OC(C)=O)CC2(C)C(=O)CCC12)C3(C)c45
PUBCHEM IUPAC INCHIKEYQDLHCMPXEPAAMD-QAIWCSMKSA-N
Solubility Level2
Vapour Pressure-7.985

Absorption and Metabolism information

XLOGP3 AA1.2
CACTVS TPSA109
BBB Level3
Absorption Level0
EXT PPB#Prediction0
AlogP981.705
EXT CYP2D6#Prediction0

Toxicological Information

Mouse Female FDANon-Carcinogen
Mouse Male FDAMulti-Carcinogen
Rat Female FDASingle-Carcinogen
Rat Male FDASingle-Carcinogen
Ames PredictionNon-Mutagen
Developmental / Reproductive ToxicityToxic
Rat Oral LD500.599599 g/kg_body_weight
Ocular IrritancyMild
Hepatotoxic#Prediction0
Effected Human Genes

Ecological Information

Aerobic Biodegradability PredictionDegradable

Hazard(s) Identification

Physical hazardsnot classified
Health hazards Mild
Environmental hazardsnot classified
About Table Headings

Compound Biological Activity

Serial No.Cas No Gene SymbolOrganismInteraction Interaction ActionsPubMed Id
1 19545-26-7 ABCB11 Homo sapiens wortmannin results in decreased activity of ABCB11 protein decreases^activity 20829430|23956101
2 19545-26-7 ACOX1 Rattus norvegicus wortmannin inhibits the reaction [bisphenol A results in decreased expression of ACOX1 mRNA] decreases^expression|decreases^reaction 23399309
3 19545-26-7 AGT Rattus norvegicus wortmannin inhibits the reaction [AGT protein results in increased expression of POSTN mRNA] decreases^reaction|increases^expression 15121739
4 19545-26-7 AHR Rattus norvegicus wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of AHR mRNA]] decreases^reaction|increases^expression 26466350
5 19545-26-7 AHR Rattus norvegicus wortmannin inhibits the reaction [INS1 protein results in decreased expression of AHR mRNA] decreases^expression|decreases^reaction 26466350
6 19545-26-7 AKT1 Didelphidae wortmannin inhibits the reaction [Neomycin results in increased phosphorylation of and results in increased activity of AKT1 protein] decreases^reaction|increases^activity|increases^phosphorylation 15800129
7 19545-26-7 AKT1 Homo sapiens wortmannin inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased activity of and results in increased phosphorylation of AKT1 protein] decreases^reaction|increases^activity|increases^phosphorylation 19801633
8 19545-26-7 AKT1 Homo sapiens wortmannin inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of AKT1 protein] decreases^reaction|increases^activity|increases^phosphorylation 11788791
9 19545-26-7 AKT1 Homo sapiens wortmannin inhibits the reaction [Copper results in increased phosphorylation of and results in increased activity of AKT1 protein] decreases^reaction|increases^activity|increases^phosphorylation 16973122
10 19545-26-7 AKT1 Homo sapiens wortmannin inhibits the reaction [Copper Sulfate results in increased phosphorylation of and results in increased activity of AKT1 protein] decreases^reaction|increases^activity|increases^phosphorylation 16973122
11 19545-26-7 AKT1 Homo sapiens wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of and results in increased activity of AKT1 protein] decreases^reaction|increases^activity|increases^phosphorylation 15608143
12 19545-26-7 AKT1 Homo sapiens wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of AKT1 protein] affects^cotreatment|decreases^reaction|increases^phosphorylation 23001822
13 19545-26-7 AKT1 Homo sapiens wortmannin inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein]] affects^cotreatment|decreases^reaction|increases^phosphorylation|increases^reaction 20562903
14 19545-26-7 AKT1 Homo sapiens wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein] decreases^reaction|increases^activity|increases^phosphorylation 15177934
15 19545-26-7 AKT1 Homo sapiens wortmannin inhibits the reaction [Simvastatin promotes the reaction [[Nifedipine co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein]] affects^cotreatment|decreases^reaction|increases^phosphorylation|increases^reaction 20562903
16 19545-26-7 AKT1 Homo sapiens wortmannin inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of AKT1 protein] decreases^reaction|increases^activity|increases^phosphorylation 12614848
17 19545-26-7 AKT1 Homo sapiens wortmannin inhibits the reaction [Zinc results in increased phosphorylation of and results in increased activity of AKT1 protein] decreases^reaction|increases^activity|increases^phosphorylation 16973122
18 19545-26-7 AKT1 Homo sapiens wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of and results in increased activity of AKT1 protein] decreases^reaction|increases^activity|increases^phosphorylation 16973122
19 19545-26-7 AKT1 Homo sapiens wortmannin results in decreased activity of AKT1 protein decreases^activity 12556562
20 19545-26-7 AKT1 Mus musculus wortmannin inhibits the reaction [INS1 protein results in increased activity of AKT1 protein] decreases^reaction|increases^activity 18591783
21 19545-26-7 AKT1 Mus musculus wortmannin inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of AKT1 protein] decreases^reaction|increases^activity|increases^phosphorylation 15178407
22 19545-26-7 AKT1 Mus musculus wortmannin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of AKT1 protein] decreases^reaction|increases^activity|increases^phosphorylation 17464197
23 19545-26-7 AKT1 Mus musculus wortmannin results in decreased activity of and results in decreased phosphorylation of AKT1 protein decreases^activity|decreases^phosphorylation 18948619
24 19545-26-7 AKT1 Mus musculus wortmannin results in decreased expression of AKT1 protein decreases^expression 15695173|17129604
25 19545-26-7 AKT1 Rattus norvegicus wortmannin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of AKT1 protein] decreases^reaction|increases^activity|increases^phosphorylation 16825486
26 19545-26-7 AKT1 Rattus norvegicus wortmannin inhibits the reaction [INS protein results in increased phosphorylation of and results in increased activity of AKT1 protein] decreases^reaction|increases^activity|increases^phosphorylation 17728140
27 19545-26-7 ALB Bos taurus [wortmannin co-treated with U 0126] inhibits the reaction [[Estrogens co-treated with ALB protein] results in increased expression of S100G mRNA] affects^cotreatment|decreases^reaction|increases^expression 20149859
28 19545-26-7 ALB Bos taurus [wortmannin co-treated with U 0126] inhibits the reaction [[Estrogens co-treated with ALB protein] results in increased expression of S100G protein] affects^cotreatment|decreases^reaction|increases^expression 20149859
29 19545-26-7 ALPI Homo sapiens wortmannin promotes the reaction [Methotrexate results in increased activity of ALPI protein] increases^activity|increases^reaction 16598758
30 19545-26-7 ALPI Homo sapiens wortmannin results in increased activity of ALPI protein increases^activity 16598758
31 19545-26-7 ANXA5 Oryctolagus cuniculus wortmannin inhibits the reaction [4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [Doxorubicin results in increased expression of ANXA5 protein]] decreases^reaction|increases^expression 18164246
32 19545-26-7 APOB Rattus norvegicus wortmannin inhibits the reaction [bisphenol A results in decreased expression of APOB mRNA] decreases^expression|decreases^reaction 23399309
33 19545-26-7 APOB Rattus norvegicus wortmannin inhibits the reaction [[bisphenol A results in decreased expression of APOB mRNA] which results in decreased abundance of Triglycerides] decreases^abundance|decreases^expression|decreases^reaction 23399309
34 19545-26-7 AREG Rattus norvegicus wortmannin results in decreased activity of AREG protein decreases^activity 12589827
35 19545-26-7 ARNT Rattus norvegicus wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of ARNT mRNA]] decreases^reaction|increases^expression 26466350
36 19545-26-7 ARNT Rattus norvegicus wortmannin inhibits the reaction [INS1 protein results in decreased expression of ARNT mRNA] decreases^expression|decreases^reaction 26466350
37 19545-26-7 ATM Mus musculus ATM protein affects the susceptibility to [wortmannin co-treated with Benzo(a)pyrene] affects^cotreatment|affects^response to substance 20888899
38 19545-26-7 ATM wortmannin results in decreased activity of ATM protein decreases^activity 22119920
39 19545-26-7 ATR wortmannin results in decreased activity of ATR protein decreases^activity 22119920
40 19545-26-7 BAX Homo sapiens wortmannin inhibits the reaction [Hydrogen Peroxide inhibits the reaction [arsenic trioxide results in increased expression of BAX protein]] decreases^reaction|increases^expression 15142122
41 19545-26-7 BAX Homo sapiens wortmannin inhibits the reaction [Leukotriene B4 results in increased expression of BAX protein] decreases^reaction|increases^expression 15970427
42 19545-26-7 BCAR1 Homo sapiens Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]] affects^cotreatment|decreases^reaction|increases^phosphorylation 10537051
43 19545-26-7 BCAR1 Homo sapiens [oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein] affects^cotreatment|decreases^reaction|increases^phosphorylation 10537051
44 19545-26-7 BCL2 Homo sapiens wortmannin inhibits the reaction [Ethanol results in increased expression of BCL2 protein] decreases^reaction|increases^expression 21410490
45 19545-26-7 BCL2 Homo sapiens wortmannin inhibits the reaction [[Hydrogen Peroxide co-treated with arsenic trioxide] results in decreased expression of BCL2 protein] affects^cotreatment|decreases^expression|decreases^reaction 15142122
46 19545-26-7 BCL2 Rattus norvegicus wortmannin inhibits the reaction [Propofol results in increased expression of BCL2 protein] decreases^reaction|increases^expression 19703415
47 19545-26-7 BCL2L1 Homo sapiens wortmannin inhibits the reaction [Hydrogen Peroxide inhibits the reaction [arsenic trioxide results in decreased expression of BCL2L1 protein]] decreases^expression|decreases^reaction 15142122
48 19545-26-7 BDNF Mus musculus wortmannin inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein] decreases^reaction|increases^expression 17209049
49 19545-26-7 BDNF Rodentia wortmannin inhibits the reaction [Morphine results in increased expression of BDNF mRNA] decreases^reaction|increases^expression 15647486
50 19545-26-7 BECN1 Rattus norvegicus wortmannin inhibits the reaction [manganese chloride results in increased expression of BECN1 protein] decreases^reaction|increases^expression 23604964
51 19545-26-7 BECN1 Rattus norvegicus wortmannin results in decreased expression of BECN1 protein decreases^expression 23604964
52 19545-26-7 BIRC2 Homo sapiens wortmannin inhibits the reaction [Acrolein results in increased expression of BIRC2 protein] decreases^reaction|increases^expression 19596284
53 19545-26-7 BIRC2 Homo sapiens wortmannin results in decreased expression of BIRC2 mRNA decreases^expression 15065019
54 19545-26-7 BIRC2 Homo sapiens wortmannin results in decreased expression of BIRC2 protein decreases^expression 15065019
55 19545-26-7 BIRC3 Homo sapiens wortmannin inhibits the reaction [Acrolein results in increased expression of BIRC3 protein] decreases^reaction|increases^expression 19596284
56 19545-26-7 BIRC5 Homo sapiens wortmannin promotes the reaction [baicalein results in decreased expression of BIRC5 protein] decreases^expression|increases^reaction 18025287
57 19545-26-7 BIRC5 Homo sapiens wortmannin results in decreased expression of BIRC5 mRNA decreases^expression 15065019
58 19545-26-7 BIRC5 Homo sapiens wortmannin results in decreased expression of BIRC5 protein decreases^expression 15065019
59 19545-26-7 BIRC5 Mus musculus wortmannin promotes the reaction [resveratrol results in decreased expression of BIRC5 protein] decreases^expression|increases^reaction 22137261
60 19545-26-7 C5 Homo sapiens wortmannin inhibits the reaction [C5 protein results in decreased expression of IL12A mRNA] decreases^expression|decreases^reaction 16116186
61 19545-26-7 C5 Homo sapiens wortmannin inhibits the reaction [C5 protein results in decreased expression of [IL12A protein binds to IL12B protein]] affects^binding|decreases^expression|decreases^reaction 16116186
62 19545-26-7 C5 Homo sapiens wortmannin inhibits the reaction [C5 protein results in decreased expression of IL12B mRNA] decreases^expression|decreases^reaction 16116186
63 19545-26-7 C5 Homo sapiens wortmannin inhibits the reaction [C5 protein results in decreased expression of IL23A mRNA] decreases^expression|decreases^reaction 16116186
64 19545-26-7 CASP3 Homo sapiens wortmannin inhibits the reaction [Hydrogen Peroxide inhibits the reaction [arsenic trioxide results in increased activity of CASP3 protein]] decreases^reaction|increases^activity 15142122
65 19545-26-7 CASP3 Homo sapiens wortmannin promotes the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP3 protein] increases^activity|increases^cleavage|increases^reaction 17935137
66 19545-26-7 CASP3 Homo sapiens wortmannin promotes the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP3 protein] increases^activity|increases^cleavage|increases^reaction 17935137
67 19545-26-7 CASP3 Homo sapiens wortmannin promotes the reaction [ochratoxin A results in increased activity of CASP3 protein] increases^activity|increases^reaction 25002221
68 19545-26-7 CASP3 Mus musculus [Rotenone co-treated with wortmannin] results in increased cleavage of CASP3 protein affects^cotreatment|increases^cleavage 26847702
69 19545-26-7 CASP3 Oryctolagus cuniculus wortmannin inhibits the reaction [4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]] decreases^reaction|increases^activity 18164246
70 19545-26-7 CASP3 Rattus norvegicus wortmannin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased activity of CASP3 protein] decreases^activity|decreases^reaction 24726520
71 19545-26-7 CASP3 Rattus norvegicus wortmannin results in decreased activity of CASP3 protein decreases^activity 21256120
72 19545-26-7 CASP7 Cricetulus griseus wortmannin inhibits the reaction [Acrolein results in increased activity of CASP7 protein] decreases^reaction|increases^activity 17196791
73 19545-26-7 CASP7 Homo sapiens wortmannin promotes the reaction [ochratoxin A results in increased activity of CASP7 protein] increases^activity|increases^reaction 25002221
74 19545-26-7 CASP8 Rattus norvegicus wortmannin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased activity of CASP8 protein] decreases^activity|decreases^reaction 24726520
75 19545-26-7 CASP9 Cricetulus griseus wortmannin inhibits the reaction [Acrolein results in increased activity of CASP9 protein] decreases^reaction|increases^activity 17196791
76 19545-26-7 CASP9 Rattus norvegicus wortmannin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased activity of CASP9 protein] decreases^activity|decreases^reaction 24726520
77 19545-26-7 CAT Mytilus galloprovincialis wortmannin inhibits the reaction [Cadmium Chloride results in increased expression of CAT mRNA] decreases^reaction|increases^expression 24316436
78 19545-26-7 CAT Mytilus galloprovincialis wortmannin inhibits the reaction [Estradiol results in increased expression of CAT mRNA] decreases^reaction|increases^expression 24316436
79 19545-26-7 CAV1 Homo sapiens wortmannin inhibits the reaction [CAV1 protein results in increased susceptibility to Hydrogen Peroxide] decreases^reaction|increases^response to substance 12640124
80 19545-26-7 CAV1 Homo sapiens wortmannin inhibits the reaction [CAV1 protein results in increased susceptibility to sodium arsenite] decreases^reaction|increases^response to substance 12640124
81 19545-26-7 CCL2 Mus musculus wortmannin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA] decreases^reaction|increases^expression 22225513
82 19545-26-7 CCL5 Mus musculus wortmannin inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide] affects^binding|decreases^reaction|increases^abundance|increases^activity 19016906
83 19545-26-7 CCL5 Mus musculus wortmannin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 mRNA] decreases^reaction|increases^expression 22225513
84 19545-26-7 CCL9 Mus musculus wortmannin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL9 mRNA] decreases^reaction|increases^expression 22225513
85 19545-26-7 CCNA2 Mus musculus wortmannin inhibits the reaction [Vanadates results in increased expression of CCNA2 protein] decreases^reaction|increases^expression 14971663
86 19545-26-7 CCNB1 Homo sapiens [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [Cadmium Chloride results in increased expression of CCNB1 protein] affects^cotreatment|decreases^reaction|increases^expression 26385184
87 19545-26-7 CCNB1 Homo sapiens [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [EGF protein results in increased expression of CCNB1 protein] affects^cotreatment|decreases^reaction|increases^expression 26385184
88 19545-26-7 CCND1 Homo sapiens wortmannin inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CCND1 mRNA] decreases^reaction|increases^expression 28321046
89 19545-26-7 CCND1 Homo sapiens wortmannin inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CCND1 protein] decreases^reaction|increases^expression 19801633
90 19545-26-7 CCND1 Mus musculus wortmannin results in decreased expression of CCND1 protein decreases^expression 15695173
91 19545-26-7 CCND2 Homo sapiens wortmannin results in increased expression of CCND2 mRNA increases^expression 14745455
92 19545-26-7 CCND3 Mus musculus [wortmannin co-treated with Imatinib Mesylate] affects the localization of CCND3 protein affects^cotreatment|affects^localization 17129604
93 19545-26-7 CCND3 Mus musculus wortmannin inhibits the reaction [KITL protein results in increased expression of CCND3 protein] decreases^reaction|increases^expression 10849422
94 19545-26-7 CCNE1 Homo sapiens [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [Cadmium Chloride results in increased expression of CCNE1 protein] affects^cotreatment|decreases^reaction|increases^expression 26385184
95 19545-26-7 CCNE1 Homo sapiens [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [EGF protein results in increased expression of CCNE1 protein] affects^cotreatment|decreases^reaction|increases^expression 26385184
96 19545-26-7 CCNE1 Mus musculus wortmannin inhibits the reaction [Vanadates results in increased expression of CCNE1 protein] decreases^reaction|increases^expression 14971663
97 19545-26-7 CCR3 Homo sapiens wortmannin inhibits the reaction [IL3 protein results in decreased expression of CCR3 protein] decreases^expression|decreases^reaction 11544337
98 19545-26-7 CD36 Homo sapiens wortmannin inhibits the reaction [Oxygen deficiency results in increased expression of CD36 mRNA] decreases^reaction|increases^expression 19640849
99 19545-26-7 CDC25A Mus musculus Imatinib Mesylate promotes the reaction [wortmannin results in decreased expression of CDC25A protein] decreases^expression|increases^reaction 17129604
100 19545-26-7 CDC25A Mus musculus wortmannin results in decreased expression of CDC25A protein decreases^expression 17129604
101 19545-26-7 CDC5L Rattus norvegicus wortmannin inhibits the reaction [NGF protein promotes the reaction [YWHAB protein binds to CDC5L protein]] affects^binding|decreases^reaction|increases^reaction 20629186
102 19545-26-7 CDH1 Homo sapiens wortmannin results in increased expression of CDH1 protein increases^expression 25856345
103 19545-26-7 CDK1 Homo sapiens [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [Cadmium Chloride results in increased expression of CDK1 protein] affects^cotreatment|decreases^reaction|increases^expression 26385184
104 19545-26-7 CDK1 Homo sapiens [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [EGF protein results in increased expression of CDK1 protein] affects^cotreatment|decreases^reaction|increases^expression 26385184
105 19545-26-7 CDK2 Homo sapiens [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [Cadmium Chloride results in increased expression of CDK2 protein] affects^cotreatment|decreases^reaction|increases^expression 26385184
106 19545-26-7 CDK2 Homo sapiens [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [EGF protein results in increased expression of CDK2 protein] affects^cotreatment|decreases^reaction|increases^expression 26385184
107 19545-26-7 CDK2 Mus musculus wortmannin results in decreased activity of CDK2 protein decreases^activity 17129604
108 19545-26-7 CDK2 Mus musculus wortmannin results in decreased expression of CDK2 protein decreases^expression 17129604
109 19545-26-7 CDKN1A Homo sapiens wortmannin inhibits the reaction [Aspirin results in increased expression of CDKN1A protein] decreases^reaction|increases^expression 21617849
110 19545-26-7 CDKN1A Homo sapiens wortmannin inhibits the reaction [docetaxel results in increased expression of CDKN1A protein] decreases^reaction|increases^expression 20878124
111 19545-26-7 CDKN1A Homo sapiens wortmannin results in decreased expression of CDKN1A protein decreases^expression 22290291
112 19545-26-7 CDKN1A Mus musculus wortmannin results in increased expression of CDKN1A protein increases^expression 15695173|17129604
113 19545-26-7 CDKN1B Homo sapiens wortmannin promotes the reaction [Doxorubicin results in increased expression of CDKN1B protein] increases^expression|increases^reaction 17935137
114 19545-26-7 CDKN1B Homo sapiens wortmannin promotes the reaction [Etoposide results in increased expression of CDKN1B protein] increases^expression|increases^reaction 17935137
115 19545-26-7 CDKN1B Mus musculus Imatinib Mesylate promotes the reaction [wortmannin results in increased expression of CDKN1B protein] increases^expression|increases^reaction 17129604
116 19545-26-7 CDKN1B Mus musculus wortmannin results in increased expression of CDKN1B protein increases^expression 17129604
117 19545-26-7 CFTR Homo sapiens wortmannin inhibits the reaction [CGP 12177 results in increased activity of CFTR protein] decreases^reaction|increases^activity 15563584
118 19545-26-7 CHEK1 Homo sapiens wortmannin inhibits the reaction [Carmustine results in increased phosphorylation of and results in increased activity of CHEK1 protein] decreases^reaction|increases^activity|increases^phosphorylation 19261750
119 19545-26-7 CHEK1 Homo sapiens wortmannin results in decreased expression of CHEK1 protein decreases^expression 22409540
120 19545-26-7 CLU Mus musculus wortmannin inhibits the reaction [Zinc results in increased expression of CLU protein] decreases^reaction|increases^expression 19288494
121 19545-26-7 COL18A1 Homo sapiens wortmannin inhibits the reaction [cobaltous chloride results in decreased expression of COL18A1 mRNA] decreases^expression|decreases^reaction 13679210
122 19545-26-7 COL18A1 Homo sapiens wortmannin inhibits the reaction [cobaltous chloride results in decreased expression of COL18A1 protein] decreases^expression|decreases^reaction 13679210
123 19545-26-7 COL1A2 Homo sapiens wortmannin inhibits the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA] decreases^reaction|increases^expression 11343241
124 19545-26-7 CPT1A Rattus norvegicus wortmannin inhibits the reaction [bisphenol A results in decreased expression of CPT1A mRNA] decreases^expression|decreases^reaction 23399309
125 19545-26-7 CREB1 Homo sapiens wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in increased phosphorylation of CREB1 protein] affects^cotreatment|decreases^reaction|increases^phosphorylation 23626723
126 19545-26-7 CRP Homo sapiens wortmannin inhibits the reaction [Dust analog results in increased expression of CRP mRNA] decreases^reaction|increases^expression 16263508
127 19545-26-7 CRP Homo sapiens wortmannin inhibits the reaction [Dust results in increased expression of CRP mRNA] decreases^reaction|increases^expression 16263508
128 19545-26-7 CRP Homo sapiens wortmannin inhibits the reaction [Particulate Matter analog results in increased expression of CRP mRNA] decreases^reaction|increases^expression 16263508
129 19545-26-7 CRP Homo sapiens wortmannin inhibits the reaction [Particulate Matter results in increased expression of CRP mRNA] decreases^reaction|increases^expression 16263508
130 19545-26-7 CRP Homo sapiens wortmannin inhibits the reaction [Vehicle Emissions analog results in increased expression of CRP mRNA] decreases^reaction|increases^expression 16263508
131 19545-26-7 CRP Homo sapiens wortmannin inhibits the reaction [Vehicle Emissions results in increased expression of CRP mRNA] decreases^reaction|increases^expression 16263508
132 19545-26-7 CSF2 Homo sapiens wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased expression of LAT2 protein] affects^cotreatment|decreases^reaction|increases^expression 23001822
133 19545-26-7 CSF2 Homo sapiens wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of RPS6 protein] affects^cotreatment|decreases^reaction|increases^phosphorylation 23001822
134 19545-26-7 CTNNB1 Homo sapiens wortmannin inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CTNNB1 protein] decreases^reaction|increases^expression 28321046
135 19545-26-7 CTNNB1 Homo sapiens wortmannin results in decreased expression of CTNNB1 protein decreases^expression 11739494
136 19545-26-7 CXCL1 Rattus norvegicus wortmannin inhibits the reaction [resveratrol results in decreased activity of CXCL1 protein] decreases^activity|decreases^reaction 20117814
137 19545-26-7 CXCL2 Homo sapiens wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein] decreases^reaction|increases^activity|increases^phosphorylation 15608143
138 19545-26-7 CXCL2 Homo sapiens wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] decreases^reaction|increases^activity|increases^phosphorylation 15608143
139 19545-26-7 CXCL2 Rattus norvegicus wortmannin inhibits the reaction [resveratrol results in decreased activity of CXCL2 protein] decreases^activity|decreases^reaction 20117814
140 19545-26-7 CXCL8 Homo sapiens wortmannin inhibits the reaction [CXCL8 protein results in increased activity of CXCR2 protein] decreases^reaction|increases^activity 12975484
141 19545-26-7 CXCL8 Homo sapiens wortmannin inhibits the reaction [CXCL8 results in decreased susceptibility to Cisplatin] decreases^reaction|decreases^response to substance 21742513
142 19545-26-7 CXCL8 Homo sapiens wortmannin inhibits the reaction [CXCL8 results in decreased susceptibility to Paclitaxel] decreases^reaction|decreases^response to substance 21742513
143 19545-26-7 CXCL8 Homo sapiens wortmannin inhibits the reaction [nickel subsulfide results in increased expression of CXCL8 mRNA] decreases^reaction|increases^expression 11978798
144 19545-26-7 CYP11A1 Rattus norvegicus wortmannin inhibits the reaction [Atrazine promotes the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]] decreases^reaction|increases^expression|increases^reaction 25253736
145 19545-26-7 CYP11A1 Rattus norvegicus wortmannin inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA] decreases^reaction|increases^expression 25253736
146 19545-26-7 CYP1A1 Rattus norvegicus wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]] decreases^reaction|increases^expression 26466350
147 19545-26-7 CYP1A1 Rattus norvegicus wortmannin inhibits the reaction [INS1 protein results in decreased expression of CYP1A1 mRNA] decreases^expression|decreases^reaction 26466350
148 19545-26-7 CYP1A2 Rattus norvegicus wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]] decreases^reaction|increases^expression 26466350
149 19545-26-7 CYP1A2 Rattus norvegicus wortmannin inhibits the reaction [INS1 protein results in decreased expression of CYP1A2 mRNA] decreases^expression|decreases^reaction 26466350
150 19545-26-7 CYP1B1 Rattus norvegicus wortmannin inhibits the reaction [INS1 protein results in decreased expression of CYP1B1 mRNA] decreases^expression|decreases^reaction 26466350
151 19545-26-7 CYP2E1 Rattus norvegicus wortmannin inhibits the reaction [INS1 protein results in decreased expression of CYP2E1 mRNA] decreases^expression|decreases^reaction 11306697
152 19545-26-7 CYP4Z1 Homo sapiens wortmannin inhibits the reaction [CYP4Z1 protein results in increased expression of TIMP2 mRNA] decreases^reaction|increases^expression 22841774
153 19545-26-7 CYP4Z1 Homo sapiens wortmannin inhibits the reaction [CYP4Z1 protein results in increased expression of VEGFA mRNA] decreases^reaction|increases^expression 22841774
154 19545-26-7 DDIT3 Homo sapiens wortmannin inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA] decreases^reaction|increases^expression 17171638
155 19545-26-7 DDIT3 Homo sapiens wortmannin inhibits the reaction [Curcumin results in increased expression of DDIT3 protein] decreases^reaction|increases^expression 17171638
156 19545-26-7 DKK1 Homo sapiens wortmannin inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of DKK1 mRNA] decreases^reaction|increases^expression 28321046
157 19545-26-7 DNMT3A Homo sapiens wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3A protein] affects^cotreatment|decreases^expression|decreases^reaction 23626723
158 19545-26-7 DNMT3B Homo sapiens wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3B protein] affects^cotreatment|decreases^expression|decreases^reaction 23626723
159 19545-26-7 DNMT3L Homo sapiens wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3L protein] affects^cotreatment|decreases^expression|decreases^reaction 23626723
160 19545-26-7 E2F1 Mus musculus wortmannin inhibits the reaction [Vanadates results in increased expression of E2F1 protein] decreases^reaction|increases^expression 14971663
161 19545-26-7 EDN1 Mus musculus wortmannin inhibits the reaction [EDN1 protein inhibits the reaction [TNF protein results in increased expression of NOS2 protein]] decreases^reaction|increases^expression 12839867
162 19545-26-7 EGF Chlorocebus aethiops wortmannin inhibits the reaction [EGF protein promotes the reaction [YWHAB protein binds to PRPF19 protein]] affects^binding|decreases^reaction|increases^reaction 20629186
163 19545-26-7 EGF naphtho(1,2-b)furan-4,5-dione inhibits the reaction [wortmannin inhibits the reaction [EGF protein results in increased activity of MMP9 protein]] decreases^reaction|increases^activity 23064031
164 19545-26-7 EGF naphtho(1,2-b)furan-4,5-dione inhibits the reaction [wortmannin inhibits the reaction [EGF protein results in increased expression of MMP9 protein]] decreases^reaction|increases^expression 23064031
165 19545-26-7 EGF wortmannin inhibits the reaction [EGF protein results in increased activity of MMP9 protein] decreases^reaction|increases^activity 23064031
166 19545-26-7 EGF wortmannin inhibits the reaction [EGF protein results in increased expression of MMP9 protein] decreases^reaction|increases^expression 23064031
167 19545-26-7 EGF wortmannin results in decreased susceptibility to EGF protein decreases^response to substance 23064031
168 19545-26-7 EGFR Homo sapiens wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein] decreases^reaction|increases^activity|increases^phosphorylation 15177934
169 19545-26-7 EPOR Homo sapiens wortmannin inhibits the reaction [testosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in increased expression of EPOR mRNA] decreases^reaction|increases^expression 20189893
170 19545-26-7 F3 Homo sapiens wortmannin promotes the reaction [Histamine results in increased expression of F3] increases^expression|increases^reaction 16009787
171 19545-26-7 FASLG Homo sapiens wortmannin inhibits the reaction [evodiamine results in increased expression of FASLG protein] decreases^reaction|increases^expression 20005289
172 19545-26-7 FGF1 Mus musculus wortmannin results in decreased activity of FGF1 protein decreases^activity 15695173
173 19545-26-7 FGF1 Rattus norvegicus wortmannin inhibits the reaction [FGF1 protein results in increased expression of POSTN mRNA] decreases^reaction|increases^expression 15121739
174 19545-26-7 FGF2 wortmannin inhibits the reaction [[FGF2 protein binds to and results in increased activity of FGFR4 protein] which results in increased phosphorylation of MAPK1 protein] affects^binding|decreases^reaction|increases^activity|increases^phosphorylation 11336793
175 19545-26-7 FGF7 Homo sapiens wortmannin inhibits the reaction [FGF7 protein results in increased expression of PLAC1 mRNA] decreases^reaction|increases^expression 15803460
176 19545-26-7 FOS Rattus norvegicus wortmannin inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of FOS mRNA] decreases^reaction|increases^expression 11687581
177 19545-26-7 FOXO3 Homo sapiens wortmannin inhibits the reaction [Cadmium Chloride results in decreased activity of FOXO3 protein] decreases^activity|decreases^reaction 23673518
178 19545-26-7 FOXP1 Homo sapiens wortmannin results in decreased expression of FOXP1 protein decreases^expression 25663935
179 19545-26-7 FSHB Rattus norvegicus wortmannin inhibits the reaction [Atrazine promotes the reaction [FSHB protein results in increased expression of STAR mRNA]] decreases^reaction|increases^expression|increases^reaction 25253736
180 19545-26-7 FSHB Rattus norvegicus wortmannin inhibits the reaction [FSHB protein results in increased expression of STAR mRNA] decreases^reaction|increases^expression 25253736
181 19545-26-7 FTH1 Homo sapiens wortmannin inhibits the reaction [2-tert-butylhydroquinone results in increased expression of FTH1 mRNA] decreases^reaction|increases^expression 23829535
182 19545-26-7 G6PC Homo sapiens wortmannin inhibits the reaction [INS protein results in decreased expression of G6PC mRNA] decreases^expression|decreases^reaction 24535192
183 19545-26-7 G6PC Homo sapiens wortmannin results in increased expression of G6PC mRNA increases^expression 24535192
184 19545-26-7 GDF15 Homo sapiens wortmannin results in increased expression of GDF15 protein increases^expression 23178381
185 19545-26-7 GJA1 Rattus norvegicus wortmannin inhibits the reaction [hydroxyflutamide results in decreased expression of GJA1 protein] decreases^expression|decreases^reaction 26437446
186 19545-26-7 GLP1R Rattus norvegicus wortmannin inhibits the reaction [Oleic Acid results in increased degradation of and results in decreased expression of GLP1R protein] decreases^expression|decreases^reaction|increases^degradation 22925809
187 19545-26-7 GRN Rattus norvegicus 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [wortmannin inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]] decreases^reaction|decreases^response to substance|increases^reaction 21820214
188 19545-26-7 GRN Rattus norvegicus U 0126 promotes the reaction [wortmannin inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]] decreases^reaction|decreases^response to substance|increases^reaction 21820214
189 19545-26-7 GRN Rattus norvegicus wortmannin inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium] decreases^reaction|decreases^response to substance 21820214
190 19545-26-7 GSK3B Homo sapiens wortmannin inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of GSK3B protein] decreases^reaction|increases^activity|increases^phosphorylation 12614848
191 19545-26-7 GSK3B Mus musculus Melatonin inhibits the reaction [wortmannin results in decreased expression of GSK3B protein modified form] decreases^expression|decreases^reaction 15842767
192 19545-26-7 GSK3B Mus musculus Vitamin E inhibits the reaction [wortmannin results in decreased expression of GSK3B protein modified form] decreases^expression|decreases^reaction 15842767
193 19545-26-7 GSK3B Mus musculus wortmannin inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of GSK3B protein modified form]] decreases^expression|decreases^reaction 23170834
194 19545-26-7 GSK3B Mus musculus wortmannin results in decreased expression of GSK3B protein modified form decreases^expression 15842767
195 19545-26-7 GSTP1 Mytilus galloprovincialis wortmannin inhibits the reaction [Cadmium Chloride results in increased expression of GSTP1 mRNA] decreases^reaction|increases^expression 24316436
196 19545-26-7 H2AFX Homo sapiens wortmannin inhibits the reaction [decitabine results in increased expression of H2AFX protein] decreases^reaction|increases^expression 17991895
197 19545-26-7 H2AFX Homo sapiens wortmannin promotes the reaction [docetaxel results in increased expression of H2AFX protein] increases^expression|increases^reaction 20878124
198 19545-26-7 HIF1A Homo sapiens [wortmannin co-treated with U 0126] inhibits the reaction [IGF1 protein promotes the reaction [cobaltous chloride results in increased expression of HIF1A protein]] affects^cotreatment|decreases^reaction|increases^expression|increases^reaction 16499871
199 19545-26-7 HIF1A Homo sapiens wortmannin inhibits the reaction [4-hydroxyestradiol results in increased expression of HIF1A protein] decreases^reaction|increases^expression 15050414
200 19545-26-7 HIF1A Homo sapiens wortmannin inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein] decreases^reaction|increases^expression 13679210
201 19545-26-7 HIF1A Homo sapiens wortmannin inhibits the reaction [CR 3294 results in decreased expression of HIF1A protein] decreases^expression|decreases^reaction 18927491
202 19545-26-7 HIF1A Homo sapiens wortmannin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein] affects^binding|decreases^reaction|increases^activity|increases^expression 20335389
203 19545-26-7 HIF1A Homo sapiens wortmannin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA] decreases^reaction|increases^expression 11424089|19640849
204 19545-26-7 HIF1A Homo sapiens wortmannin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein] decreases^reaction|increases^expression 20153296
205 19545-26-7 HIF1A Homo sapiens wortmannin inhibits the reaction [sodium arsenite results in increased expression of HIF1A protein] decreases^reaction|increases^expression 23968725
206 19545-26-7 HIF1A Homo sapiens wortmannin results in decreased expression of HIF1A protein decreases^expression 14726529
207 19545-26-7 HIF1A Sus scrofa wortmannin inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein] decreases^reaction|increases^expression 11514583
208 19545-26-7 HIF1A Sus scrofa wortmannin inhibits the reaction [TNF protein results in increased expression of HIF1A protein] decreases^reaction|increases^expression 11514583
209 19545-26-7 HMOX1 Bos taurus wortmannin affects the expression of HMOX1 protein affects^expression 19131585
210 19545-26-7 HMOX1 Homo sapiens wortmannin inhibits the reaction [10-nitro-oleic acid results in increased expression of HMOX1 protein] decreases^reaction|increases^expression 23845594
211 19545-26-7 HMOX1 Homo sapiens wortmannin inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein] decreases^reaction|increases^expression 23845594
212 19545-26-7 HMOX1 Homo sapiens wortmannin inhibits the reaction [Acrolein results in increased expression of HMOX1 mRNA] decreases^reaction|increases^expression 18048804
213 19545-26-7 HMOX1 Homo sapiens wortmannin inhibits the reaction [plumbagin results in increased expression of HMOX1 protein] decreases^reaction|increases^expression 20028456
214 19545-26-7 HMOX1 Mus musculus wortmannin inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA] decreases^reaction|increases^expression 24423726
215 19545-26-7 HMOX1 Mus musculus wortmannin inhibits the reaction [bis(4-hydroxycinnamoyl)methane results in increased expression of HMOX1 mRNA] decreases^reaction|increases^expression 17535857
216 19545-26-7 HMOX1 Mus musculus wortmannin inhibits the reaction [bis(4-hydroxycinnamoyl)methane results in increased expression of HMOX1 protein] decreases^reaction|increases^expression 17535857
217 19545-26-7 HMOX1 Mus musculus wortmannin inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA] decreases^reaction|increases^expression 17535857
218 19545-26-7 HMOX1 Mus musculus wortmannin inhibits the reaction [Curcumin results in increased expression of HMOX1 protein] decreases^reaction|increases^expression 17535857
219 19545-26-7 HMOX1 Mus musculus wortmannin inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA] decreases^reaction|increases^expression 17535857
220 19545-26-7 HMOX1 Mus musculus wortmannin inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 protein] decreases^reaction|increases^expression 17535857
221 19545-26-7 HMOX1 Rattus norvegicus wortmannin inhibits the reaction [astringin results in increased expression of HMOX1 protein] decreases^reaction|increases^expression 22022464
222 19545-26-7 HMOX1 Rattus norvegicus wortmannin inhibits the reaction [naringenin results in increased expression of HMOX1 protein] decreases^reaction|increases^expression 22709785
223 19545-26-7 HMOX1 Rattus norvegicus wortmannin inhibits the reaction [Quercetin results in increased expression of HMOX1 mRNA] decreases^reaction|increases^expression 22056766
224 19545-26-7 HMOX1 Rattus norvegicus wortmannin inhibits the reaction [resveratrol results in increased expression of HMOX1 protein] decreases^reaction|increases^expression 20117814
225 19545-26-7 HSF1 Homo sapiens wortmannin inhibits the reaction [Oxygen deficiency results in increased expression of HSF1 mRNA] decreases^reaction|increases^expression 11424089
226 19545-26-7 HSPA1A Homo sapiens wortmannin results in decreased expression of HSPA1A protein decreases^expression 20090934
227 19545-26-7 HSPA1A Homo sapiens wortmannin results in decreased expression of HSPA1A protein alternative form decreases^expression 20090934
228 19545-26-7 HSPA5 Homo sapiens wortmannin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 mRNA] decreases^reaction|increases^expression 19428936
229 19545-26-7 ICAM1 Homo sapiens wortmannin inhibits the reaction [Norepinephrine promotes the reaction [REL protein binds to ICAM1 promoter]] affects^binding|decreases^reaction|increases^reaction 23114885
230 19545-26-7 ICAM1 Rattus norvegicus wortmannin inhibits the reaction [resveratrol results in decreased activity of ICAM1 protein] decreases^activity|decreases^reaction 20117814
231 19545-26-7 IFNB1 Homo sapiens wortmannin inhibits the reaction [[Vehicle Emissions analog co-treated with Poly I-C] results in increased expression of IFNB1 mRNA] affects^cotreatment|decreases^reaction|increases^expression 16399790
232 19545-26-7 IFNG Homo sapiens wortmannin inhibits the reaction [Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]] affects^cotreatment|decreases^reaction|increases^abundance 16968468
233 19545-26-7 IFNG Homo sapiens wortmannin promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA] affects^cotreatment|increases^expression|increases^reaction 25352548
234 19545-26-7 IGF1 Homo sapiens wortmannin inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein] decreases^reaction|increases^activity 17520698
235 19545-26-7 IGF1 Homo sapiens wortmannin inhibits the reaction [IGF1 protein results in increased activity of MAPK1 protein] decreases^reaction|increases^activity 16499871
236 19545-26-7 IGF1 Homo sapiens wortmannin inhibits the reaction [IGF1 protein results in increased activity of MAPK3 protein] decreases^reaction|increases^activity 16499871
237 19545-26-7 IGF1 Homo sapiens wortmannin inhibits the reaction [IGF1 protein results in increased activity of MTR protein] decreases^reaction|increases^activity 14745455
238 19545-26-7 IGF1 Homo sapiens wortmannin inhibits the reaction [IGF1 protein results in increased expression of MYCN protein] decreases^reaction|increases^expression 12569580
239 19545-26-7 IGF1 Homo sapiens wortmannin inhibits the reaction [IGF1 protein results in increased expression of ZNF143 protein] decreases^reaction|increases^expression 20733350
240 19545-26-7 IGF1 Mus musculus wortmannin inhibits the reaction [IGF1 protein results in increased expression of MYH4 mRNA] decreases^reaction|increases^expression 19657059
241 19545-26-7 IGF1 wortmannin results in decreased susceptibility to IGF1 protein decreases^response to substance 18398872
242 19545-26-7 IGF2 Homo sapiens wortmannin inhibits the reaction [IGF2 protein results in increased expression of STS mRNA] decreases^reaction|increases^expression 24055520
243 19545-26-7 IGF2 Homo sapiens wortmannin results in decreased susceptibility to IGF2 protein decreases^response to substance 24055520
244 19545-26-7 IL12A Homo sapiens wortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]] affects^binding|decreases^expression|decreases^reaction 16116186
245 19545-26-7 IL17A Mus musculus wortmannin inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A mRNA] decreases^reaction|increases^expression 17982072
246 19545-26-7 IL1B Homo sapiens wortmannin inhibits the reaction [IL1B protein results in increased activity of MMP12 protein] decreases^reaction|increases^activity 16359550
247 19545-26-7 IL1B Homo sapiens wortmannin inhibits the reaction [IL1B protein results in increased expression of MMP12 mRNA] decreases^reaction|increases^expression 16359550
248 19545-26-7 IL1B Mus musculus wortmannin inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL1B protein]] decreases^reaction|increases^expression|increases^secretion 22952890
249 19545-26-7 IL1B Mus musculus wortmannin inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]] decreases^reaction|increases^expression 22952890
250 19545-26-7 IL1B [wortmannin co-treated with IL1B protein] promotes the reaction [SIRT1 protein binds to SCX protein] affects^binding|affects^cotreatment|increases^reaction 22936809
251 19545-26-7 IL1B wortmannin inhibits the reaction [IL1B protein results in decreased expression of SIRT1 protein] decreases^expression|decreases^reaction 22936809
252 19545-26-7 IL1B wortmannin inhibits the reaction [IL1B protein results in increased expression of MMP13 protein] decreases^reaction|increases^expression 22936809
253 19545-26-7 IL1B wortmannin inhibits the reaction [IL1B protein results in increased expression of MMP1 protein] decreases^reaction|increases^expression 22936809
254 19545-26-7 IL1B wortmannin inhibits the reaction [IL1B protein results in increased expression of MMP9 protein] decreases^reaction|increases^expression 22936809
255 19545-26-7 IL1B wortmannin inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein] decreases^reaction|increases^expression 22936809
256 19545-26-7 IL1B wortmannin inhibits the reaction [IL1B protein results in increased phosphorylation of and results in increased activity of RELA protein] decreases^reaction|increases^activity|increases^phosphorylation 22936809
257 19545-26-7 IL1B wortmannin results in decreased susceptibility to IL1B protein decreases^response to substance 22936809
258 19545-26-7 IL1RN Mus musculus wortmannin results in decreased expression of IL1RN mRNA decreases^expression 26847702
259 19545-26-7 IL6 Mus musculus wortmannin inhibits the reaction [di-n-butyltin results in increased expression of IL6 mRNA] decreases^reaction|increases^expression 24631921
260 19545-26-7 IL6 Mus musculus wortmannin inhibits the reaction [di-n-butyltin results in increased expression of IL6 protein] decreases^reaction|increases^expression 24631921
261 19545-26-7 IL6 Rattus norvegicus wortmannin inhibits the reaction [resveratrol results in decreased activity of IL6 protein] decreases^activity|decreases^reaction 20117814
262 19545-26-7 INS Homo sapiens [wortmannin co-treated with INS protein] inhibits the reaction [Glucose affects the localization of PDX1 protein] affects^cotreatment|affects^localization|decreases^reaction 11574405
263 19545-26-7 INS Homo sapiens wortmannin inhibits the reaction [INS protein results in decreased susceptibility to Coumaric Acids] decreases^reaction|decreases^response to substance 20015842
264 19545-26-7 INS wortmannin inhibits the reaction [INS protein results in decreased expression of PCK1 mRNA] decreases^expression|decreases^reaction 10446394
265 19545-26-7 INS1 Mus musculus wortmannin inhibits the reaction [INS1 protein results in increased expression of SORT1 protein] decreases^reaction|increases^expression 25805502
266 19545-26-7 IRAK3 Mus musculus wortmannin results in decreased expression of IRAK3 mRNA decreases^expression 26847702
267 19545-26-7 ITGAV Homo sapiens wortmannin inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]] affects^activity|affects^binding|affects^localization|decreases^reaction 15213856
268 19545-26-7 ITGB2 Homo sapiens wortmannin inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein] decreases^reaction|increases^activity 16963453
269 19545-26-7 KLF4 Rattus norvegicus wortmannin inhibits the reaction [Estradiol results in increased expression of KLF4 protein] decreases^reaction|increases^expression 21484412
270 19545-26-7 KNG1 Rattus norvegicus KNG1 protein inhibits the reaction [[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein] affects^cotreatment|decreases^reaction|increases^phosphorylation 10537051
271 19545-26-7 LEP Mus musculus wortmannin results in decreased expression of LEP mRNA decreases^expression 19254925
272 19545-26-7 LEP wortmannin results in decreased susceptibility to LEP protein decreases^response to substance 17993459
273 19545-26-7 MAP1LC3B Mus musculus wortmannin inhibits the reaction [Rotenone results in increased expression of MAP1LC3B protein] decreases^reaction|increases^expression 26847702
274 19545-26-7 MAP1LC3B Mus musculus wortmannin results in decreased expression of MAP1LC3B protein decreases^expression 26847702
275 19545-26-7 MAPK1 Homo sapiens [bisindolylmaleimide I co-treated with wortmannin] inhibits the reaction [Zinc results in increased phosphorylation of MAPK1 protein] affects^cotreatment|decreases^reaction|increases^phosphorylation 20522546
276 19545-26-7 MAPK1 Homo sapiens wortmannin inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein] decreases^reaction|increases^activity|increases^phosphorylation 19477951
277 19545-26-7 MAPK1 Homo sapiens wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein] decreases^reaction|increases^activity|increases^phosphorylation 15177934
278 19545-26-7 MAPK3 Homo sapiens [bisindolylmaleimide I co-treated with wortmannin] inhibits the reaction [Zinc results in increased phosphorylation of MAPK3 protein] affects^cotreatment|decreases^reaction|increases^phosphorylation 20522546
279 19545-26-7 MAPK3 Homo sapiens wortmannin inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein] decreases^reaction|increases^activity|increases^phosphorylation 19477951
280 19545-26-7 MAPK3 Homo sapiens wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] decreases^reaction|increases^activity|increases^phosphorylation 15177934
281 19545-26-7 MCL1 Homo sapiens wortmannin inhibits the reaction [Leukotriene B4 results in increased expression of MCL1 protein] decreases^reaction|increases^expression 15970427
282 19545-26-7 MCL1 Homo sapiens wortmannin promotes the reaction [Doxorubicin results in decreased expression of MCL1 protein] decreases^expression|increases^reaction 17935137
283 19545-26-7 MCL1 Homo sapiens wortmannin promotes the reaction [Etoposide results in decreased expression of MCL1 protein] decreases^expression|increases^reaction 17935137
284 19545-26-7 MCL1 Homo sapiens wortmannin results in decreased expression of MCL1 protein decreases^expression 23353698
285 19545-26-7 MIR200A Homo sapiens [wortmannin co-treated with Dehydroepiandrosterone] results in increased expression of MIR200A mRNA affects^cotreatment|increases^expression 25969534
286 19545-26-7 MIR21 Homo sapiens wortmannin inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA] decreases^reaction|increases^expression 25969534
287 19545-26-7 MIR21 Homo sapiens wortmannin inhibits the reaction [fludioxonil results in increased expression of MIR21 mRNA] decreases^reaction|increases^expression 23052036
288 19545-26-7 MIR21 Homo sapiens wortmannin inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of MIR21 mRNA] decreases^reaction|increases^expression 23052036
289 19545-26-7 MIR22 Homo sapiens [wortmannin co-treated with Dehydroepiandrosterone] results in increased expression of MIR22 mRNA affects^cotreatment|increases^expression 25969534
290 19545-26-7 MMP2 Homo sapiens brazilein promotes the reaction [wortmannin results in decreased expression of and results in decreased activity of MMP2 protein] decreases^activity|decreases^expression|increases^reaction 23707804
291 19545-26-7 MMP2 Homo sapiens wortmannin promotes the reaction [brazilein results in decreased expression of and results in decreased activity of MMP2 protein] decreases^activity|decreases^expression|increases^reaction 23707804
292 19545-26-7 MMP2 Homo sapiens wortmannin results in decreased expression of and results in decreased activity of MMP2 protein decreases^activity|decreases^expression 23707804
293 19545-26-7 MMP2 Homo sapiens wortmannin results in decreased expression of MMP2 decreases^expression 23707804
294 19545-26-7 MMP9 Homo sapiens wortmannin inhibits the reaction [fucoidan results in decreased expression of MMP9] decreases^expression|decreases^reaction 24333868
295 19545-26-7 MMP9 Homo sapiens wortmannin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP9 protein] decreases^reaction|increases^activity|increases^expression 23288142
296 19545-26-7 MMP9 Homo sapiens wortmannin promotes the reaction [ovatodiolide results in decreased activity of MMP9 protein] decreases^activity|increases^reaction 22033475
297 19545-26-7 MMP9 Homo sapiens wortmannin results in decreased activity of MMP9 protein decreases^activity 22033475
298 19545-26-7 MMP9 Rattus norvegicus wortmannin inhibits the reaction [Adenosine Triphosphate results in increased activity of MMP9 protein] decreases^reaction|increases^activity 20195827
299 19545-26-7 MPO Rattus norvegicus wortmannin inhibits the reaction [resveratrol results in decreased activity of MPO protein] decreases^activity|decreases^reaction 20117814
300 19545-26-7 MS4A2 Mus musculus MS4A2 protein mutant form results in decreased susceptibility to wortmannin decreases^response to substance 19467708
301 19545-26-7 MT1 Mus musculus wortmannin inhibits the reaction [Cadmium Chloride results in increased expression of MT1 mRNA] decreases^reaction|increases^expression 11551972
302 19545-26-7 MT1 Mus musculus wortmannin inhibits the reaction [zinc chloride results in increased expression of MT1 mRNA] decreases^reaction|increases^expression 11551972
303 19545-26-7 MT3 Homo sapiens wortmannin results in decreased susceptibility to MT3 protein decreases^response to substance 19767621
304 19545-26-7 MTR Homo sapiens wortmannin inhibits the reaction [Dopamine results in increased activity of MTR protein] decreases^reaction|increases^activity 14745455
305 19545-26-7 NEDD4 Rattus norvegicus wortmannin inhibits the reaction [Zinc Sulfate promotes the reaction [PTEN protein binds to NEDD4 protein]] affects^binding|decreases^reaction|increases^reaction 20100827
306 19545-26-7 NFKB1 Mus musculus wortmannin inhibits the reaction [Ozone results in increased activity of [NFKB1 protein binds to RELA protein]] affects^binding|decreases^reaction|increases^activity 18207479
307 19545-26-7 NFKBIA Mus musculus wortmannin inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of NFKBIA protein]] decreases^expression|decreases^reaction 23170834
308 19545-26-7 NGF Mus musculus wortmannin inhibits the reaction [NGF results in increased susceptibility to Capsaicin] decreases^reaction|increases^response to substance 12815188
309 19545-26-7 NGF Rattus norvegicus wortmannin inhibits the reaction [NGF protein promotes the reaction [YWHAB protein binds to PRPF19 protein modified form]] affects^binding|decreases^reaction|increases^reaction 20629186
310 19545-26-7 NGF Rattus norvegicus wortmannin results in decreased activity of NGF protein decreases^activity 21975456
311 19545-26-7 NOS2 Mus musculus carvedilol promotes the reaction [wortmannin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]] decreases^reaction|increases^expression|increases^reaction 17159805
312 19545-26-7 NOS2 Mus musculus wortmannin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] decreases^reaction|increases^expression 17159805
313 19545-26-7 NOS2 Mus musculus wortmannin inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]] decreases^reaction|increases^expression 22952890
314 19545-26-7 NOS2 Mus musculus wortmannin inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]] decreases^reaction|increases^expression 22952890
315 19545-26-7 NOS3 Homo sapiens wortmannin inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of NOS3 protein] decreases^reaction|increases^activity|increases^phosphorylation 11788791
316 19545-26-7 NOS3 Homo sapiens wortmannin inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of and results in increased expression of NOS3 protein]] affects^cotreatment|decreases^reaction|increases^expression|increases^phosphorylation|increases^reaction 20562903
317 19545-26-7 NOS3 Homo sapiens wortmannin inhibits the reaction [Progesterone promotes the reaction [Estradiol results in increased activity of NOS3 protein]] decreases^reaction|increases^activity|increases^reaction 15358673
318 19545-26-7 NOS3 Homo sapiens wortmannin inhibits the reaction [Progesterone results in increased activity of NOS3 protein] decreases^reaction|increases^activity 15358673
319 19545-26-7 NOS3 Homo sapiens wortmannin inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of NOS3 protein] decreases^reaction|increases^activity|increases^phosphorylation 18296501
320 19545-26-7 NOS3 Homo sapiens wortmannin inhibits the reaction [Simvastatin promotes the reaction [[Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of and results in increased expression of NOS3 protein]] affects^cotreatment|decreases^reaction|increases^expression|increases^phosphorylation|increases^reaction 20562903
321 19545-26-7 NOS3 Rattus norvegicus wortmannin affects the reaction [Carbon Tetrachloride results in increased phosphorylation of and results in increased activity of NOS3 protein] affects^reaction|increases^activity|increases^phosphorylation 18317400
322 19545-26-7 NOTCH1 Mus musculus wortmannin inhibits the reaction [Zinc results in decreased activity of NOTCH1 protein] decreases^activity|decreases^reaction 17513037
323 19545-26-7 NQO1 Homo sapiens wortmannin inhibits the reaction [plumbagin results in increased expression of NQO1 protein] decreases^reaction|increases^expression 20028456
324 19545-26-7 NR5A1 Homo sapiens wortmannin inhibits the reaction [Estradiol results in increased activity of NR5A1 protein] decreases^reaction|increases^activity 19549922
325 19545-26-7 OLR1 wortmannin affects the expression of OLR1 protein affects^expression 19150883
326 19545-26-7 PCK1 Rattus norvegicus [troglitazone co-treated with wortmannin] results in decreased expression of PCK1 mRNA affects^cotreatment|decreases^expression 10446394
327 19545-26-7 PDCD4 Homo sapiens wortmannin results in increased expression of PDCD4 mRNA increases^expression 17259349
328 19545-26-7 PDCD4 Homo sapiens wortmannin results in increased expression of PDCD4 protein increases^expression 17259349
329 19545-26-7 PDX1 Homo sapiens wortmannin inhibits the reaction [Glucose results in increased phosphorylation of and results in increased activity of PDX1 protein] decreases^reaction|increases^activity|increases^phosphorylation 9873045
330 19545-26-7 PIK3CA Homo sapiens wortmannin inhibits the reaction [Sirolimus results in increased activity of PIK3CA protein] decreases^reaction|increases^activity 16227402
331 19545-26-7 PIK3CA Homo sapiens wortmannin results in decreased activity of PIK3CA protein decreases^activity 19036708
332 19545-26-7 PIK3CB Homo sapiens wortmannin results in decreased activity of PIK3CB protein decreases^activity 11931710
333 19545-26-7 PIK3CD Mus musculus wortmannin results in decreased activity of PIK3CD protein decreases^activity 21644799
334 19545-26-7 PIK3CG Mus musculus wortmannin inhibits the reaction [Isoproterenol results in increased activity of PIK3CG protein] decreases^reaction|increases^activity 15178407
335 19545-26-7 PIK3CG Mus musculus wortmannin results in decreased activity of PIK3CG protein decreases^activity 21644799
336 19545-26-7 PIK3R1 Homo sapiens wortmannin results in decreased activity of PIK3R1 protein decreases^activity 19036708
337 19545-26-7 PIK3R1 Rattus norvegicus wortmannin inhibits the reaction [nonylphenol results in decreased expression of PIK3R1 protein] decreases^expression|decreases^reaction 27832966
338 19545-26-7 PPARA Rattus norvegicus wortmannin inhibits the reaction [bisphenol A results in decreased expression of PPARA mRNA] decreases^expression|decreases^reaction 23399309
339 19545-26-7 PPARD Rattus norvegicus wortmannin inhibits the reaction [bisphenol A results in decreased expression of PPARD mRNA] decreases^expression|decreases^reaction 23399309
340 19545-26-7 PPARG Rattus norvegicus wortmannin inhibits the reaction [bisphenol A results in decreased expression of PPARG mRNA] decreases^expression|decreases^reaction 23399309
341 19545-26-7 PPM1D Homo sapiens wortmannin inhibits the reaction [Soil Pollutants results in increased expression of PPM1D protein] decreases^reaction|increases^expression 22409540
342 19545-26-7 PRKCD Homo sapiens wortmannin inhibits the reaction [Oxygen deficiency results in increased activity of and results in increased localization of PRKCD protein] decreases^reaction|increases^activity|increases^localization 11424089
343 19545-26-7 PRKDC Mus musculus PRKDC protein affects the susceptibility to [wortmannin co-treated with Benzo(a)pyrene] affects^cotreatment|affects^response to substance 20888899
344 19545-26-7 PTEN Homo sapiens wortmannin inhibits the reaction [PTEN protein results in increased susceptibility to Doxorubicin] decreases^reaction|increases^response to substance 17935137
345 19545-26-7 PTEN Homo sapiens wortmannin inhibits the reaction [PTEN protein results in increased susceptibility to Etoposide] decreases^reaction|increases^response to substance 17935137
346 19545-26-7 PTEN Rattus norvegicus wortmannin inhibits the reaction [nonylphenol results in decreased expression of PTEN protein] decreases^expression|decreases^reaction 27832966
347 19545-26-7 PTEN Rattus norvegicus wortmannin inhibits the reaction [Zinc Sulfate results in decreased expression of PTEN protein] decreases^expression|decreases^reaction 20100827
348 19545-26-7 PTGER1 Homo sapiens wortmannin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased phosphorylation of RPS6 protein] affects^binding|decreases^reaction|increases^activity|increases^phosphorylation 20335389
349 19545-26-7 PTGS2 Homo sapiens wortmannin inhibits the reaction [PTGS2 protein results in decreased susceptibility to Carboplatin] decreases^reaction|decreases^response to substance 18089846
350 19545-26-7 PTGS2 Homo sapiens wortmannin inhibits the reaction [sodium arsenite results in increased expression of PTGS2 protein] decreases^reaction|increases^expression 23968725
351 19545-26-7 PTGS2 Homo sapiens wortmannin inhibits the reaction [Zinc results in increased expression of PTGS2 mRNA] decreases^reaction|increases^expression 15980035
352 19545-26-7 PTGS2 Homo sapiens wortmannin inhibits the reaction [Zinc results in increased expression of PTGS2 protein] decreases^reaction|increases^expression 15980035
353 19545-26-7 PTGS2 Mus musculus wortmannin inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 mRNA] decreases^reaction|increases^expression 18840457
354 19545-26-7 PTGS2 Mus musculus wortmannin inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 protein] decreases^reaction|increases^expression 18840457
355 19545-26-7 PTGS2 Mus musculus wortmannin inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]] decreases^reaction|increases^expression 22952890
356 19545-26-7 PTGS2 Mus musculus wortmannin inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]] decreases^reaction|increases^expression 22952890
357 19545-26-7 PTGS2 wortmannin inhibits the reaction [Glucose results in increased expression of PTGS2 protein] decreases^reaction|increases^expression 15213311
358 19545-26-7 PTK2 Homo sapiens Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]] affects^cotreatment|decreases^reaction|increases^phosphorylation 10537051
359 19545-26-7 PTK2 Homo sapiens Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]] affects^cotreatment|decreases^reaction|increases^phosphorylation 10537051
360 19545-26-7 PTK2 Homo sapiens Atropine inhibits the reaction [oxotremorine M promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with wortmannin] results in increased phosphorylation of PTK2 protein]] affects^cotreatment|decreases^reaction|increases^phosphorylation|increases^reaction 10537051
361 19545-26-7 PTK2 Homo sapiens oxotremorine M inhibits the reaction [[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein] affects^cotreatment|decreases^reaction|increases^phosphorylation 10537051
362 19545-26-7 PTK2 Homo sapiens oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein] affects^cotreatment|decreases^reaction|increases^phosphorylation 10537051
363 19545-26-7 PTK2 Homo sapiens oxotremorine M promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with wortmannin] results in increased phosphorylation of PTK2 protein] affects^cotreatment|increases^phosphorylation|increases^reaction 10537051
364 19545-26-7 PTK2 Homo sapiens [Pilocarpine co-treated with wortmannin] results in increased phosphorylation of PTK2 protein affects^cotreatment|increases^phosphorylation 10537051
365 19545-26-7 PTK2 Homo sapiens [Tetradecanoylphorbol Acetate co-treated with wortmannin] results in increased phosphorylation of PTK2 protein affects^cotreatment|increases^phosphorylation 10537051
366 19545-26-7 PTK2 Homo sapiens [wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein affects^cotreatment|increases^phosphorylation 10537051
367 19545-26-7 PTK2 Homo sapiens [wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein affects^cotreatment|increases^phosphorylation 10537051
368 19545-26-7 PTK2 Homo sapiens [wortmannin co-treated with Tetradecanoylphorbol Acetate] inhibits the reaction [oxotremorine M results in increased phosphorylation of PTK2 protein] affects^cotreatment|decreases^reaction|increases^phosphorylation 10537051
369 19545-26-7 PXN Homo sapiens Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]] affects^cotreatment|decreases^reaction|increases^phosphorylation 10537051
370 19545-26-7 PXN Homo sapiens [oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein] affects^cotreatment|decreases^reaction|increases^phosphorylation 10537051
371 19545-26-7 RAD23B Homo sapiens wortmannin inhibits the reaction [Cisplatin results in increased expression of RAD23B protein] decreases^reaction|increases^expression 21742020
372 19545-26-7 RAD50 Homo sapiens [wortmannin co-treated with docetaxel] results in decreased expression of RAD50 protein affects^cotreatment|decreases^expression 20878124
373 19545-26-7 RELA Mus musculus wortmannin inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of RELA protein] decreases^reaction|increases^expression 17982072
374 19545-26-7 RIOX2 Homo sapiens wortmannin inhibits the reaction [arsenic trichloride results in increased expression of RIOX2 mRNA] decreases^reaction|increases^expression 24434654
375 19545-26-7 RPS6KB1 Mus musculus wortmannin inhibits the reaction [arsenite affects the activity of RPS6KB1 protein] affects^activity|decreases^reaction 14516795
376 19545-26-7 RPS6KB1 wortmannin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of RPS6KB1 protein] decreases^reaction|increases^activity|increases^phosphorylation 11861821
377 19545-26-7 RPS6KB2 Homo sapiens wortmannin inhibits the reaction [Phosphatidic Acids results in increased activity of RPS6KB2 protein] decreases^reaction|increases^activity 12087098
378 19545-26-7 SCG2 Homo sapiens wortmannin results in decreased activity of SCG2 protein alternative form decreases^activity 9473216
379 19545-26-7 SCT Rattus norvegicus wortmannin inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid] decreases^reaction|increases^response to substance 22194894
380 19545-26-7 SCT Rattus norvegicus wortmannin inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid analog] decreases^reaction|increases^response to substance 22194894
381 19545-26-7 SCT Rattus norvegicus wortmannin inhibits the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT] decreases^reaction|increases^activity 22194894
382 19545-26-7 SELENOP Homo sapiens wortmannin results in increased expression of SELENOP protein increases^expression 24535192
383 19545-26-7 SERPINE1 Homo sapiens wortmannin inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of SERPINE1 protein] decreases^reaction|increases^expression|increases^secretion 16458614
384 19545-26-7 SERPINE1 Homo sapiens wortmannin inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA] decreases^reaction|increases^expression 16458614
385 19545-26-7 SERPINH1 Homo sapiens wortmannin inhibits the reaction [cobaltous chloride results in decreased expression of SERPINH1 mRNA] decreases^expression|decreases^reaction 13679210
386 19545-26-7 SERPINH1 Homo sapiens wortmannin inhibits the reaction [cobaltous chloride results in decreased expression of SERPINH1 protein] decreases^expression|decreases^reaction 13679210
387 19545-26-7 SESN2 wortmannin inhibits the reaction [Lipopolysaccharides results in increased expression of SESN2 protein] decreases^reaction|increases^expression 25637945
388 19545-26-7 SFTPC Mus musculus wortmannin results in decreased expression of SFTPC protein decreases^expression 15695173
389 19545-26-7 SHBG Rattus norvegicus wortmannin inhibits the reaction [nonylphenol results in increased expression of SHBG mRNA] decreases^reaction|increases^expression 27832966
390 19545-26-7 SIRT1 Homo sapiens wortmannin promotes the reaction [arsenic disulfide results in decreased expression of SIRT1 protein] decreases^expression|increases^reaction 18298901
391 19545-26-7 SIRT1 Mus musculus wortmannin inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]] decreases^expression|decreases^reaction 22952890
392 19545-26-7 SLC1A1 Rattus norvegicus wortmannin inhibits the reaction [Carbamazepine results in increased activity of SLC1A1 protein] decreases^reaction|increases^activity 16150575
393 19545-26-7 SLC1A1 Rattus norvegicus wortmannin inhibits the reaction [Pregabalin results in increased activity of SLC1A1 protein] decreases^reaction|increases^activity 22511482
394 19545-26-7 SLC1A1 Rattus norvegicus wortmannin inhibits the reaction [Progesterone results in increased activity of SLC1A1 protein] decreases^reaction|increases^activity 23602688
395 19545-26-7 SLC1A1 Rattus norvegicus wortmannin results in decreased activity of SLC1A1 protein decreases^activity 23262392|23602688|24355585
396 19545-26-7 SLC2A5 Rattus norvegicus wortmannin inhibits the reaction [Fructose results in increased expression of and results in increased activity of SLC2A5 protein] decreases^reaction|increases^activity|increases^expression 15691865
397 19545-26-7 SLC5A5 Homo sapiens wortmannin inhibits the reaction [Carbamazepine promotes the reaction [Tretinoin results in increased expression of SLC5A5 protein]] decreases^reaction|increases^expression|increases^reaction 20300827
398 19545-26-7 SOCS3 Mus musculus wortmannin inhibits the reaction [Gemfibrozil results in increased expression of SOCS3 mRNA] decreases^reaction|increases^expression 22685291
399 19545-26-7 SOCS3 Mus musculus wortmannin inhibits the reaction [Gemfibrozil results in increased expression of SOCS3 protein] decreases^reaction|increases^expression 22685291
400 19545-26-7 SOD Mytilus galloprovincialis wortmannin inhibits the reaction [Cadmium Chloride results in increased expression of SOD mRNA] decreases^reaction|increases^expression 24316436
401 19545-26-7 SOD2 Rattus norvegicus wortmannin results in increased expression of SOD2 mRNA increases^expression 20596034
402 19545-26-7 SORT1 Mus musculus wortmannin results in decreased expression of and results in increased degradation of SORT1 protein decreases^expression|increases^degradation 25805502
403 19545-26-7 SQSTM1 Mus musculus [wortmannin co-treated with Ethanol] results in increased expression of SQSTM1 protein affects^cotreatment|increases^expression 22459179
404 19545-26-7 SQSTM1 Mus musculus wortmannin results in decreased expression of SQSTM1 protein decreases^expression 22459179
405 19545-26-7 SQSTM1 Mus musculus wortmannin results in increased expression of SQSTM1 protein increases^expression 22459179
406 19545-26-7 STS Homo sapiens wortmannin inhibits the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased activity of STS protein] decreases^reaction|increases^activity 16178010
407 19545-26-7 STS Homo sapiens wortmannin inhibits the reaction [AGN 195183 results in increased activity of STS protein] decreases^reaction|increases^activity 16178010
408 19545-26-7 STS Homo sapiens wortmannin inhibits the reaction [tazarotene results in increased activity of STS protein] decreases^reaction|increases^activity 16178010
409 19545-26-7 STS Homo sapiens wortmannin inhibits the reaction [Tretinoin results in increased activity of STS protein] decreases^reaction|increases^activity 16178010
410 19545-26-7 TGIF1 Homo sapiens wortmannin inhibits the reaction [arsenic trioxide results in increased expression of TGIF1 protein] decreases^reaction|increases^expression 21649584
411 19545-26-7 TH Mus musculus wortmannin affects the reaction [HU 211 results in decreased expression of TH mRNA] affects^reaction|decreases^expression 18950629
412 19545-26-7 TH Rattus norvegicus [wortmannin co-treated with manganese chloride] results in decreased expression of TH protein affects^cotreatment|decreases^expression 23604964
413 19545-26-7 TH wortmannin inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of TH mRNA] decreases^reaction|increases^expression 18950629
414 19545-26-7 THRA Homo sapiens wortmannin binds to and results in decreased activity of THRA protein affects^binding|decreases^activity 25752796
415 19545-26-7 TJP1 Homo sapiens wortmannin inhibits the reaction [telmisartan results in decreased expression of TJP1 mRNA] decreases^expression|decreases^reaction 19252288
416 19545-26-7 TJP1 Homo sapiens wortmannin inhibits the reaction [telmisartan results in decreased expression of TJP1 protein] decreases^expression|decreases^reaction 19252288
417 19545-26-7 TLR1 Gallus gallus [FSL-1 lipoprotein, synthetic co-treated with wortmannin] results in increased expression of TLR1 mRNA affects^cotreatment|increases^expression 23405061
418 19545-26-7 TLR1 Gallus gallus [wortmannin co-treated with Pam(3)CSK(4) peptide] results in increased expression of TLR1 mRNA affects^cotreatment|increases^expression 23405061
419 19545-26-7 TLR21 Gallus gallus wortmannin inhibits the reaction [CPG-oligonucleotide results in increased expression of TLR21 mRNA] decreases^reaction|increases^expression 23405061
420 19545-26-7 TLR2B Gallus gallus wortmannin inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased expression of TLR2B mRNA] decreases^reaction|increases^expression 23405061
421 19545-26-7 TLR3 Gallus gallus [Poly I-C co-treated with wortmannin] results in decreased expression of TLR3 mRNA affects^cotreatment|decreases^expression 23405061
422 19545-26-7 TLR6 Gallus gallus [wortmannin co-treated with Pam(3)CSK(4) peptide] results in increased expression of TLR6 mRNA affects^cotreatment|increases^expression 23405061
423 19545-26-7 TLR7 Gallus gallus wortmannin inhibits the reaction [resiquimod results in increased expression of TLR7 mRNA] decreases^reaction|increases^expression 23405061
424 19545-26-7 TNF Mus musculus wortmannin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] decreases^reaction|increases^expression 17464197
425 19545-26-7 TNF Mus musculus wortmannin inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]] decreases^reaction|increases^expression|increases^secretion 22952890
426 19545-26-7 TNF Mus musculus wortmannin inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]] decreases^reaction|increases^expression 22952890
427 19545-26-7 TP53 Homo sapiens wortmannin inhibits the reaction [Asbestos, Serpentine results in increased expression of TP53 protein] decreases^reaction|increases^expression 12676607
428 19545-26-7 TP53 Homo sapiens wortmannin inhibits the reaction [Mustard Gas results in increased expression of TP53 protein] decreases^reaction|increases^expression 22119920
429 19545-26-7 TP53 Homo sapiens wortmannin promotes the reaction [arsenic disulfide results in increased expression of and results in increased phosphorylation of TP53 protein] increases^expression|increases^phosphorylation|increases^reaction 18298901
430 19545-26-7 TP53 Homo sapiens wortmannin results in decreased phosphorylation of and results in decreased expression of TP53 protein decreases^expression|decreases^phosphorylation 22290291
431 19545-26-7 TP53 Rattus norvegicus wortmannin inhibits the reaction [Diethylnitrosamine results in increased expression of TP53 protein] decreases^reaction|increases^expression 11751435
432 19545-26-7 TP73 Homo sapiens wortmannin promotes the reaction [Cisplatin results in increased expression of TP73 protein] increases^expression|increases^reaction 21214929
433 19545-26-7 TP73 Homo sapiens wortmannin promotes the reaction [Doxorubicin results in increased expression of TP73 protein] increases^expression|increases^reaction 21214929
434 19545-26-7 VEGFA Homo sapiens wortmannin inhibits the reaction [4-hydroxyestradiol results in increased expression of VEGFA protein] decreases^reaction|increases^expression 15050414
435 19545-26-7 VEGFA Homo sapiens wortmannin inhibits the reaction [cobaltous chloride results in increased expression of VEGFA mRNA] decreases^reaction|increases^expression 13679210
436 19545-26-7 VEGFA Homo sapiens wortmannin inhibits the reaction [cobaltous chloride results in increased expression of VEGFA protein] decreases^reaction|increases^expression 13679210
437 19545-26-7 VEGFA Homo sapiens wortmannin inhibits the reaction [oxaliplatin results in increased expression of VEGFA protein] decreases^reaction|increases^expression 18790786
438 19545-26-7 VEGFA Homo sapiens wortmannin inhibits the reaction [sodium arsenite results in increased expression of VEGFA protein] decreases^reaction|increases^expression 23968725
439 19545-26-7 VIM Homo sapiens wortmannin results in decreased expression of VIM protein decreases^expression 25856345
440 19545-26-7 XRCC5 Homo sapiens [wortmannin co-treated with docetaxel] results in decreased expression of XRCC5 protein affects^cotreatment|decreases^expression 20878124
441 19545-26-7 XRCC6 Homo sapiens [wortmannin co-treated with docetaxel] results in decreased expression of XRCC6 protein affects^cotreatment|decreases^expression 20878124
442 19545-26-7 YAP1 Homo sapiens wortmannin promotes the reaction [Cisplatin results in increased expression of YAP1 protein modified form] increases^expression|increases^reaction 21214929
443 19545-26-7 YAP1 Homo sapiens wortmannin promotes the reaction [Doxorubicin results in increased expression of YAP1 protein modified form] increases^expression|increases^reaction 21214929
Serial No.Activity Name DetailsReferences (PubMed)Other details EPA (U.S)Clinical Trials (U.S. NIH)
1 19545-26-7 wortmannin

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