AromaDb: A Database of Plant's Aroma Molecules

Salicylic Acid Details

: IUPAC Name
2-hydroxybenzoic acid
:Chemical Class
Acid
:CAS Registry Number
69-72-7
:Description

:Fragrance Type
nutty aroma

Physical and Chemical properties

PUBCHEM ID338
Molecular Weight (mg/mol)138.121
Molecular FormulaC7H6O3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
IUPAC Name2-hydroxybenzoic acid
Canonical SMILESO=C(O)c1ccccc1O
PUBCHEM IUPAC INCHIKEYYGSDEFSMJLZEOE-UHFFFAOYSA-N
Solubility Level4
Vapour Pressure-4.23

Absorption and Metabolism information

XLOGP3 AA
CACTVS TPSA57.5
BBB Level3
Absorption Level0
EXT PPB#Prediction0
AlogP981.217
EXT CYP2D6#Prediction0

Toxicological Information

Mouse Female FDANon-Carcinogen
Mouse Male FDASingle-Carcinogen
Rat Female FDANon-Carcinogen
Rat Male FDANon-Carcinogen
Ames PredictionNon-Mutagen
Developmental / Reproductive ToxicityToxic
Rat Oral LD501.63853 g/kg_body_weight
Ocular IrritancyModerate
Hepatotoxic#Prediction1
Effected Human Genes

Ecological Information

Aerobic Biodegradability PredictionDegradable

Hazard(s) Identification

Physical hazardsnot classified
Health hazards None
Environmental hazardsnot classified
About Table Headings

Compound Biological Activity

Serial No.Cas No Gene SymbolOrganismInteraction Interaction ActionsPubMed Id
1 69-72-7 ADIPOQ Rattus norvegicus Salicylic Acid inhibits the reaction [Palmitic Acid results in decreased expression of ADIPOQ mRNA] decreases^expression|decreases^reaction 25108154
2 69-72-7 AKR1C1 Homo sapiens benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Salicylic Acid inhibits the reaction [AKR1C1 protein results in decreased susceptibility to Cisplatin]] decreases^reaction|decreases^response to substance|increases^reaction 23165153
3 69-72-7 AKR1C1 Homo sapiens Salicylic Acid inhibits the reaction [AKR1C1 protein results in decreased susceptibility to Cisplatin] decreases^reaction|decreases^response to substance 23165153
4 69-72-7 AKR1C1 Homo sapiens Salicylic Acid results in decreased activity of AKR1C1 protein decreases^activity 19010312|23165153
5 69-72-7 AKR1C2 Homo sapiens Salicylic Acid results in decreased activity of AKR1C2 protein decreases^activity 19010312
6 69-72-7 AKR1C2 Homo sapiens Salicylic Acid results in increased expression of AKR1C2 mRNA increases^expression 20491607
7 69-72-7 AKR1C3 Homo sapiens Salicylic Acid results in decreased activity of AKR1C3 protein decreases^activity 19010312
8 69-72-7 ARG1 Rattus norvegicus Salicylic Acid inhibits the reaction [Palmitic Acid results in decreased expression of ARG1 mRNA] decreases^expression|decreases^reaction 25108154
9 69-72-7 ASIC3 Rattus norvegicus Salicylic Acid results in decreased activity of ASIC3 protein decreases^activity 11588175
10 69-72-7 CCL2 Rattus norvegicus Salicylic Acid inhibits the reaction [Palmitic Acid results in increased expression of CCL2 mRNA] decreases^reaction|increases^expression 25108154
11 69-72-7 CXCL2 Mus musculus Salicylic Acid results in increased expression of CXCL2 protein increases^expression 23178550
12 69-72-7 IL1A Mus musculus Salicylic Acid results in increased expression of IL1A protein increases^expression 23178550
13 69-72-7 IL4 Homo sapiens Salicylic Acid results in decreased expression of IL4 mRNA decreases^expression 11238116
14 69-72-7 IL6 Mus musculus Salicylic Acid inhibits the reaction [Mercury results in increased expression of IL6] decreases^reaction|increases^expression 23742082
15 69-72-7 IL6 Rattus norvegicus Salicylic Acid inhibits the reaction [Palmitic Acid results in increased expression of IL6 mRNA] decreases^reaction|increases^expression 25108154
16 69-72-7 MAFF Homo sapiens Salicylic Acid results in increased expression of MAFF mRNA increases^expression 20491607
17 69-72-7 MPO Homo sapiens Salicylic Acid results in increased activity of MPO protein increases^activity 24060682
18 69-72-7 MT1A Homo sapiens Salicylic Acid results in increased expression of MT1A mRNA increases^expression 20491607
19 69-72-7 NOS2 Rattus norvegicus Salicylic Acid inhibits the reaction [Palmitic Acid results in increased expression of NOS2 mRNA] decreases^reaction|increases^expression 25108154
20 69-72-7 NR3C1 Oncorhynchus mykiss Salicylic Acid results in decreased expression of NR3C1 protein decreases^expression 16551645
21 69-72-7 PPARG Rattus norvegicus Salicylic Acid inhibits the reaction [Palmitic Acid results in decreased expression of PPARG mRNA] decreases^expression|decreases^reaction 25108154
22 69-72-7 PSMB10 Homo sapiens Salicylic Acid results in increased expression of PSMB10 mRNA increases^expression 23165153
23 69-72-7 PSMB9 Homo sapiens Salicylic Acid results in increased expression of PSMB9 mRNA increases^expression 23165153
24 69-72-7 PTGS2 Salicylic Acid results in decreased expression of PTGS2 mRNA decreases^expression 16936242
25 69-72-7 SIRT1 Rattus norvegicus [Niacinamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Salicylic Acid decreases^activity|decreases^response to substance 25108154
26 69-72-7 SLC22A11 Homo sapiens Salicylic Acid results in decreased activity of SLC22A11 protein decreases^activity 12388633
27 69-72-7 SLC22A6 Homo sapiens Salicylic Acid results in decreased activity of SLC22A6 protein decreases^activity 12388633
28 69-72-7 SLC22A7 Homo sapiens Salicylic Acid results in decreased activity of SLC22A7 protein decreases^activity 12388633
29 69-72-7 SLC22A9 Homo sapiens Salicylic Acid results in decreased activity of SLC22A9 protein decreases^activity 12388633
30 69-72-7 STAR Oncorhynchus mykiss Salicylic Acid results in decreased expression of STAR mRNA decreases^expression 16551645
31 69-72-7 TNF Rattus norvegicus Salicylic Acid inhibits the reaction [Palmitic Acid results in increased expression of TNF mRNA] decreases^reaction|increases^expression 25108154
32 69-72-7 TSPO Oncorhynchus mykiss Salicylic Acid results in decreased expression of TSPO mRNA decreases^expression 16551645
33 69-72-7 TXN Homo sapiens Salicylic Acid results in increased expression of TXN mRNA increases^expression 20491607
34 69-72-7 ABCG2 Bos taurus ABCG2 protein binds to and results in increased transport of Sodium Salicylate affects^binding|increases^transport 23652544
35 69-72-7 ANXA5 Homo sapiens Sodium Salicylate results in increased activity of ANXA5 protein increases^activity 10090950
36 69-72-7 CASP1 Rattus norvegicus Sodium Salicylate inhibits the reaction [Paraquat results in decreased activity of CASP1 protein] decreases^activity|decreases^reaction 17561093
37 69-72-7 CASP1 Rattus norvegicus Sodium Salicylate results in increased activity of CASP1 protein increases^activity 17561093
38 69-72-7 CASP3 Homo sapiens Sodium Salicylate results in increased activity of CASP3 protein increases^activity 10090950
39 69-72-7 CASP3 Rattus norvegicus Sodium Salicylate inhibits the reaction [Paraquat results in increased activity of CASP3 protein] decreases^reaction|increases^activity 17561093
40 69-72-7 CASP8 Rattus norvegicus Sodium Salicylate inhibits the reaction [Paraquat results in increased activity of CASP8 protein] decreases^reaction|increases^activity 17561093
41 69-72-7 CASP8 Rattus norvegicus Sodium Salicylate results in increased activity of CASP8 protein increases^activity 17561093
42 69-72-7 CDKN1A Homo sapiens Sodium Salicylate results in decreased activity of CDKN1A protein decreases^activity 15190207
43 69-72-7 CXCL8 Homo sapiens Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA] decreases^reaction|increases^expression 10328874
44 69-72-7 EGF Mus musculus Sodium Salicylate promotes the reaction [[EGF protein co-treated with IGF1 protein] results in increased phosphorylation of and results in increased activity of RPS6KB1 protein] affects^cotreatment|increases^activity|increases^phosphorylation|increases^reaction 10993886
45 69-72-7 FOXO3 Mus musculus Sodium Salicylate results in increased expression of FOXO3 protein increases^expression 21303813
46 69-72-7 HSF1 Homo sapiens Sodium Salicylate results in increased activity of HSF1 protein increases^activity 10328874
47 69-72-7 HSPA1B Mus musculus Sodium Salicylate affects the expression of HSPA1B protein affects^expression 16184763
48 69-72-7 HSPA7 Homo sapiens Sodium Salicylate results in decreased expression of HSPA7 mRNA decreases^expression 10328874
49 69-72-7 ICAM1 Homo sapiens Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA] decreases^reaction|increases^expression 10328874
50 69-72-7 IFNG Mus musculus Sodium Salicylate results in decreased expression of IFNG protein decreases^expression 21303813
51 69-72-7 IKBKB Mus musculus Sodium Salicylate results in decreased expression of IKBKB protein modified form decreases^expression 21303813
52 69-72-7 IKBKB Sodium Salicylate results in decreased activity of IKBKB protein decreases^activity 10480951
53 69-72-7 IL10 Homo sapiens Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA] decreases^reaction|increases^expression 10328874
54 69-72-7 IL1B Homo sapiens Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL1B protein] decreases^reaction|increases^expression|increases^secretion 10328874
55 69-72-7 IL1B Homo sapiens Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] decreases^reaction|increases^expression 10328874
56 69-72-7 IL1B Homo sapiens Sodium Salicylate results in decreased expression of IL1B mRNA decreases^expression 10328874
57 69-72-7 IL1B Mus musculus Sodium Salicylate results in decreased expression of IL1B protein decreases^expression 21303813
58 69-72-7 IL4 Homo sapiens Sodium Salicylate affects the reaction [IL4 results in increased activity of STAT6 protein] affects^reaction|increases^activity 19767084
59 69-72-7 IL6 Mus musculus Sodium Salicylate results in decreased expression of IL6 protein decreases^expression 21303813
60 69-72-7 JUN Rattus norvegicus Sodium Salicylate inhibits the reaction [Paraquat results in increased expression of JUN protein] decreases^reaction|increases^expression 17561093
61 69-72-7 JUN Rattus norvegicus Sodium Salicylate results in decreased expression of JUN protein decreases^expression 17561093
62 69-72-7 MAPK1 Mus musculus Sodium Salicylate results in decreased phosphorylation of and results in decreased activity of MAPK1 protein decreases^activity|decreases^phosphorylation 10993886
63 69-72-7 MAPK1 Rattus norvegicus Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAPK1 protein] decreases^reaction|increases^activity|increases^phosphorylation 10357911
64 69-72-7 MAPK3 Mus musculus Sodium Salicylate results in decreased phosphorylation of and results in decreased activity of MAPK3 protein decreases^activity|decreases^phosphorylation 10993886
65 69-72-7 MAPK3 Rattus norvegicus Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAPK3 protein] decreases^reaction|increases^activity|increases^phosphorylation 10357911
66 69-72-7 MCL1 Homo sapiens Sodium Salicylate results in increased expression of MCL1 protein increases^expression 10090950
67 69-72-7 MMP3 Bos taurus Sodium Salicylate inhibits the reaction [TNF protein results in increased expression of MMP3 mRNA] decreases^reaction|increases^expression 10336562
68 69-72-7 NFKB1 Mus musculus Sodium Salicylate inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]] affects^binding|affects^cotreatment|decreases^reaction|increases^reaction 9281604
69 69-72-7 NFKBIA Sodium Salicylate inhibits the reaction [TNF protein results in decreased expression of NFKBIA protein] decreases^expression|decreases^reaction 10480951
70 69-72-7 NOS2 Mus musculus Sodium Salicylate results in decreased expression of NOS2 protein decreases^expression 10860828
71 69-72-7 NOS2 Mus musculus [Sodium Salicylate results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide decreases^chemical synthesis|decreases^expression 10860828
72 69-72-7 PEPD Homo sapiens Sodium Salicylate results in decreased activity of PEPD protein decreases^activity 16991207
73 69-72-7 PPARG Cavia Sodium Salicylate results in increased expression of PPARG mRNA increases^expression 18560754
74 69-72-7 PTGS1 Ovis aries 12-HPETE inhibits the reaction [Sodium Salicylate results in decreased activity of PTGS1 protein] decreases^activity|decreases^reaction 12538810
75 69-72-7 PTGS1 Ovis aries 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid inhibits the reaction [Sodium Salicylate results in decreased activity of PTGS1 protein] decreases^activity|decreases^reaction 12538810
76 69-72-7 PTGS1 Ovis aries Hydrogen Peroxide affects the reaction [Sodium Salicylate results in decreased activity of PTGS1 protein] affects^reaction|decreases^activity 12538810
77 69-72-7 PTGS1 Ovis aries Manganese inhibits the reaction [12-HPETE inhibits the reaction [Sodium Salicylate results in decreased activity of PTGS1 protein]] decreases^activity|decreases^reaction 12538810
78 69-72-7 PTGS1 Ovis aries [PTGS1 protein results in increased abundance of prostaglandin G2] inhibits the reaction [Sodium Salicylate results in decreased activity of PTGS1 protein] decreases^activity|decreases^reaction|increases^abundance 12538810
79 69-72-7 PTGS1 Ovis aries Sodium Salicylate results in decreased activity of PTGS1 protein decreases^activity 12538810
80 69-72-7 PTGS2 Homo sapiens Sodium Salicylate results in increased expression of PTGS2 mRNA increases^expression 14742690
81 69-72-7 PTGS2 Homo sapiens Sodium Salicylate results in increased expression of PTGS2 protein increases^expression 14742690
82 69-72-7 PTGS2 Mus musculus 12-HPETE inhibits the reaction [Sodium Salicylate results in decreased activity of PTGS2 protein] decreases^activity|decreases^reaction 12538810
83 69-72-7 PTGS2 Mus musculus Hydrogen Peroxide affects the reaction [Sodium Salicylate results in decreased activity of PTGS2 protein] affects^reaction|decreases^activity 12538810
84 69-72-7 PTGS2 Mus musculus [PTGS2 protein results in increased abundance of prostaglandin G2] inhibits the reaction [Sodium Salicylate results in decreased activity of PTGS2 protein] decreases^activity|decreases^reaction|increases^abundance 12538810
85 69-72-7 PTGS2 Mus musculus Sodium Salicylate results in decreased activity of PTGS2 protein decreases^activity 12538810
86 69-72-7 RELA Homo sapiens Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein] decreases^reaction|increases^expression 10328874
87 69-72-7 RPS6KB1 Mus musculus Sodium Salicylate inhibits the reaction [SB 203580 promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]] decreases^reaction|increases^activity|increases^phosphorylation|increases^reaction 10993886
88 69-72-7 RPS6KB1 Mus musculus Sodium Salicylate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of RPS6KB1 protein] decreases^reaction|increases^activity|increases^phosphorylation 10993886
89 69-72-7 RPS6KB1 Mus musculus Sodium Salicylate results in decreased phosphorylation of and results in decreased activity of RPS6KB1 protein decreases^activity|decreases^phosphorylation 10993886
90 69-72-7 SCARB1 Homo sapiens Sodium Salicylate results in decreased expression of SCARB1 protein decreases^expression 16816107
91 69-72-7 SCARB1 Homo sapiens Sodium Salicylate results in increased expression of SCARB1 protein increases^expression 16816107
92 69-72-7 SLC26A5 Rattus norvegicus Sodium Salicylate results in increased expression of SLC26A5 mRNA increases^expression 19173110
93 69-72-7 SLC26A5 Rattus norvegicus Sodium Salicylate results in increased expression of SLC26A5 protein increases^expression 19173110
94 69-72-7 SOD2 Mus musculus Sodium Salicylate results in increased expression of SOD2 protein increases^expression 21303813
95 69-72-7 TNF Homo sapiens Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein] decreases^reaction|increases^expression|increases^secretion 10328874
96 69-72-7 TNF Homo sapiens Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] decreases^reaction|increases^expression 10328874
97 69-72-7 TNF Mus musculus Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] decreases^reaction|increases^expression 17568627
98 69-72-7 TNF Mus musculus Sodium Salicylate results in decreased expression of TNF protein decreases^expression 21303813
99 69-72-7 TP53 Rattus norvegicus Sodium Salicylate inhibits the reaction [Paraquat results in increased expression of TP53 protein] decreases^reaction|increases^expression 17561093
Serial No.Activity Name DetailsReferences (PubMed)Other details EPA (U.S)Clinical Trials (U.S. NIH)
1 69-72-7 Salicylic Acid

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