1 |
127-17-3 |
ACACA |
Homo sapiens |
[Pyruvic Acid co-treated with Glucose] results in increased phosphorylation of ACACA protein |
affects^cotreatment|increases^phosphorylation |
19071085 |
2 |
127-17-3 |
ADRB3 |
Mus musculus |
[BRL 37344 binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Pyruvic Acid |
affects^binding|increases^abundance|increases^activity |
20930473 |
3 |
127-17-3 |
ATP5A1 |
Rattus norvegicus |
[Glucose deficiency co-treated with Galactose co-treated with Pyruvic Acid] results in increased expression of ATP5A1 protein |
affects^cotreatment|increases^expression |
25997894 |
4 |
127-17-3 |
BECN1 |
Rattus norvegicus |
[Glucose deficiency co-treated with Galactose co-treated with Pyruvic Acid] inhibits the reaction [Doxorubicin results in decreased expression of BECN1 protein] |
affects^cotreatment|decreases^expression|decreases^reaction |
25997894 |
5 |
127-17-3 |
CASP3 |
Rattus norvegicus |
[Glucose deficiency co-treated with Galactose co-treated with Pyruvic Acid] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein] |
affects^cotreatment|decreases^reaction|increases^activity |
25997894 |
6 |
127-17-3 |
CASP9 |
Rattus norvegicus |
[Glucose deficiency co-treated with Galactose co-treated with Pyruvic Acid] inhibits the reaction [Doxorubicin results in increased activity of CASP9 protein] |
affects^cotreatment|decreases^reaction|increases^activity |
25997894 |
7 |
127-17-3 |
COX1 |
Rattus norvegicus |
[Glucose deficiency co-treated with Galactose co-treated with Pyruvic Acid] results in increased expression of COX1 protein |
affects^cotreatment|increases^expression |
25997894 |
8 |
127-17-3 |
CTBP1 |
Homo sapiens |
Pyruvic Acid inhibits the reaction [CTBP1 protein binds to CTBP2 protein] |
affects^binding|decreases^reaction |
18184656 |
9 |
127-17-3 |
CTBP1 |
Homo sapiens |
Pyruvic Acid inhibits the reaction [CTBP1 protein binds to NR5A1 protein] |
affects^binding|decreases^reaction |
18184656 |
10 |
127-17-3 |
CTBP1 |
Homo sapiens |
Pyruvic Acid promotes the reaction [CTBP1 protein binds to CYP17A1 promoter] |
affects^binding|increases^reaction |
18184656 |
11 |
127-17-3 |
CTBP2 |
Homo sapiens |
Pyruvic Acid promotes the reaction [CTBP2 protein binds to CYP17A1 promoter] |
affects^binding|increases^reaction |
18184656 |
12 |
127-17-3 |
CYP17A1 |
Homo sapiens |
Pyruvic Acid promotes the reaction [NR5A1 protein binds to CYP17A1 promoter] |
affects^binding|increases^reaction |
18184656 |
13 |
127-17-3 |
CYP17A1 |
Homo sapiens |
Pyruvic Acid results in increased expression of CYP17A1 mRNA |
increases^expression |
18184656 |
14 |
127-17-3 |
CYP3A11 |
Mus musculus |
Pyruvic Acid inhibits the reaction [PPARGC1A protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A11 mRNA]] |
decreases^reaction|increases^expression|increases^reaction |
21933665 |
15 |
127-17-3 |
CYP3A11 |
Mus musculus |
SIRT1 mRNA affects the reaction [Pyruvic Acid inhibits the reaction [PPARGC1A protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A11 mRNA]]] |
affects^reaction|decreases^reaction|increases^expression|increases^reaction |
21933665 |
16 |
127-17-3 |
IL4 |
Rattus norvegicus |
Pyruvic Acid inhibits the reaction [Mercuric Chloride results in increased expression of IL4 mRNA] |
decreases^reaction|increases^expression |
11222498 |
17 |
127-17-3 |
KCNH2 |
Homo sapiens |
Pyruvic Acid inhibits the reaction [[Deoxyglucose co-treated with Glucose deficiency] results in decreased activity of KCNH2 protein] |
affects^cotreatment|decreases^activity|decreases^reaction |
12531891 |
18 |
127-17-3 |
ME1 |
Columbidae |
[Pyruvic Acid co-treated with manganese chloride] promotes the reaction [NADP binds to ME1 protein] |
affects^binding|affects^cotreatment|increases^reaction |
7356971 |
19 |
127-17-3 |
NDUFB8 |
Rattus norvegicus |
[Glucose deficiency co-treated with Galactose co-treated with Pyruvic Acid] results in increased expression of NDUFB8 protein |
affects^cotreatment|increases^expression |
25997894 |
20 |
127-17-3 |
PDK4 |
Mus musculus |
[PDK4 affects the abundance of Pyruvic Acid] which results in increased expression of SIRT1 |
affects^abundance|increases^expression |
21182459 |
21 |
127-17-3 |
PPARGC1A |
Homo sapiens |
[Pyruvic Acid co-treated with Glucose] results in decreased acetylation of PPARGC1A protein |
affects^cotreatment|decreases^acetylation |
19071085 |
22 |
127-17-3 |
PRNP |
Ovis aries |
Pyruvic Acid inhibits the reaction [Peroxynitrous Acid results in decreased activity of PRNP protein] |
decreases^activity|decreases^reaction |
14713301 |
23 |
127-17-3 |
SIRT1 |
Homo sapiens |
[Glucose deficiency co-treated with Galactose co-treated with Amino Acids co-treated with Pyruvic Acid] inhibits the reaction [resveratrol results in increased expression of SIRT1 protein] |
affects^cotreatment|decreases^reaction|increases^expression |
27358235 |
24 |
127-17-3 |
SIRT1 |
Homo sapiens |
[Pyruvic Acid co-treated with Glucose] results in increased expression of and results in increased activity of SIRT1 protein |
affects^cotreatment|increases^activity|increases^expression |
19071085 |
25 |
127-17-3 |
SIRT1 |
Mus musculus |
Pyruvic Acid results in increased expression of SIRT1 mRNA |
increases^expression |
21933665 |
26 |
127-17-3 |
SLC2A4 |
Mus musculus |
Pyruvic Acid inhibits the reaction [Palmitates results in decreased expression of SLC2A4 mRNA] |
decreases^expression|decreases^reaction |
21802492 |
27 |
127-17-3 |
SOD1 |
Homo sapiens |
Pyruvic Acid inhibits the reaction [SOD1 protein mutant form results in increased susceptibility to cupric chloride] |
decreases^reaction|increases^response to substance |
15812313 |
28 |
127-17-3 |
TFAM |
Rattus norvegicus |
[Glucose deficiency co-treated with Galactose co-treated with Pyruvic Acid] results in increased expression of TFAM protein |
affects^cotreatment|increases^expression |
25997894 |
29 |
127-17-3 |
TP53 |
Rattus norvegicus |
[Glucose deficiency co-treated with Galactose co-treated with Pyruvic Acid] inhibits the reaction [Doxorubicin results in increased expression of TP53 protein] |
affects^cotreatment|decreases^reaction|increases^expression |
25997894 |
Serial No. | Activity Name | Details | References (PubMed) | Other details EPA (U.S) | Clinical Trials (U.S. NIH) |
---|
1 | | |
|
127-17-3 |
Acetylformic acid |