| Entry | O64961 |
Entry Name | TPSGC_SOLLC |
| Sequence Status | reviewed |
| Protein Name | Germacrene C synthase (EC 4.2.3.60) (Sesquiterpene synthase 1) |
| Sequence Length | 548 |
| Gene Name | SSTLE1 |
| Organism | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) |
| EC Number | 4.2.3.60 |
Protein Function | FUNCTION: Involved in the biosynthesis of germacrene C, one of the most abundant sesquiterpene in the leaf oil of tomato. Produces mainly germacrene C, but also smaller amounts of germacrene A, B and D when used with farnesyl diphosphate as substrate. No activity with geranyl diphosphate or geranylgeranyl diphosphate. {ECO:0000269|PubMed:11090225, ECO:0000269|PubMed:9482865}. |
Pathway | PATHWAY: Secondary metabolite biosynthesis; terpenoid biosynthesis. |
Protein Active Site | |
Reference | 9482865; 11090225 |
Domain | DOMAIN: The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg(2+). {ECO:0000250}. |
Motif | MOTIF 300 304 DDXXD motif. |
Protein Family | Terpene synthase family, Tpsa subfamily |
Ensembl ID | |
Biocyc ID | PF01397;PF03936; |
Protein Existence | Evidence at protein level |
Subunit Structure | |
Gene Ontology Biological Process | terpenoid biosynthetic process [GO:0016114] |
Gene Ontology Cellular Component | cytoplasm [GO:0005737] |
Gene Ontology | cytoplasm [GO:0005737]; germacrene C synthase activity [GO:0102904]; magnesium ion binding [GO:0000287]; terpene synthase activity [GO:0010333]; terpenoid biosynthetic process [GO:0016114] |
Gene Ontology Molecular Function | germacrene C synthase activity [GO:0102904]; magnesium ion binding [GO:0000287]; terpene synthase activity [GO:0010333] |
GO ID | GO:0000287; GO:0005737; GO:0010333; GO:0016114; GO:0102904 |
String Database | |
PDB | |
RefSeq | NP_001234055.1; |
KEGG | sly:543549; |
InterPro | IPR008949;IPR034741;IPR001906;IPR036965;IPR005630;IPR008930; |
Protein Sequence | MAASSADKCRPLANFHPSVWGYHFLSYTHEITNQEKVEVDEYKETIRKMLVETCDNSTQKLVLIDAMQRLGVAYHFDNEIETSIQNIFDASSKQNDNDNNLYVVSLRFRLVRQQGHYMSSDVFKQFTNQDGKFKETLTNDVQGLLSLYEASHLRVRNEEILEEALTFTTTHLESIVSNLSNNNNSLKVEVGEALTQPIRMTLPRMGARKYISIYENNDAHHHLLLKFAKLDFNMLQKFHQRELSDLTRWWKDLDFANKYPYARDRLVECYFWILGVYFEPKYSRARKMMTKVLNLTSIIDDTFDAYATFDELVTFNDAIQRWDANAIDSIQPYMRPAYQALLDIYSEMEQVLSKEGKLDRVYYAKNEMKKLVRAYFKETQWLNDCDHIPKYEEQVENAIVSAGYMMISTTCLVGIEEFISHETFEWLMNESVIVRASALIARAMNDIVGHEDEQERGHVASLIECYMKDYGASKQETYIKFLKEVTNAWKDINKQFFRPTEVPMFVLERVLNLTRVADTLYKEKDTYTNAKGKLKNMINSILIESVKI |
