TerSynDB

Plant Name: O65402
Terpene synthases genes
Entry O65402
Entry NameERG12_ARATH
Sequence Statusreviewed
Protein NameSqualene epoxidase 6 (AtSQE6) (EC 1.14.14.17) (Squalene monooxygenase 1,2) (SE 1,2)
Sequence Length517
Gene NameSQE6 SQP1,2 At5g24160 K12G2.4
OrganismArabidopsis thaliana (Mouse-ear cress)
EC Number1.14.14.17
Protein FunctionFUNCTION: Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway. {ECO:0000250|UniProtKB:Q9SM02}.
PathwayPATHWAY: Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 2/3.
Protein Active Site
Reference10350086; 10048488; 17426032
Domain
Motif
Protein FamilySqualene monooxygenase family
Ensembl IDAT5G24160.1;
Biocyc IDPF08491;
Protein ExistenceEvidence at transcript level
Subunit Structure
Gene Ontology Biological Process
Gene Ontology Cellular Componentendoplasmic reticulum [GO:0005783]; integral component of membrane
Gene Ontologyendoplasmic reticulum [GO:0005783]; integral component of membrane [GO:0016021]; flavin adenine dinucleotide binding [GO:0050660]; squalene monooxygenase activity [GO:0004506]
Gene Ontology Molecular Function flavin adenine dinucleotide binding [GO:0050660]; squalene monooxygenase activity [GO:0004506]
GO IDGO:0004506; GO:0005783; GO:0016021; GO:0050660
String Database3702.AT5G24160.1;
PDB
RefSeqNP_197804.1;
KEGGath:AT5G24160;
InterProIPR036188;IPR013698;
Protein SequenceMAFTHVCLWTLVAFVLTWTVFYLTNMKKKATDLADTVAEDQKDGAADVIIVGAGVGGSALAYALAKDGRRVHVIERDMREPERMMGEFMQPGGRLMLSKLGLQDCLEDIDAQKATGLAVYKDGKEADAPFPVDNNNFSYEPSARSFHNGRFVQQLRRKAFSLSNVRLEEGTVKSLLEEKGVVKGVTYKNKEGEETTALAPLTVVCDGCYSNLRRSLNDDNNAEIMSYIVGYISKNCRLEEPEKLHLILSKPSFTMVYQISSTDVRCGFEVLPENFPSIANGEMSTFMKNTIVPQVPPKLRKIFLKGIDEGAHIKVVPAKRMTSTLSKKKGVIVLGDAFNMRHPVVASGMMVLLSDILILRRLLQPLSNLGDANKVSEVINSFYDIRKPMSATVNTLGNAFSQVLIGSTDEAKEAMRQGVYDYLCSGGFRTSGMMALLGGMNPRPLSLVYHLCAITLSSIGQLLSPFPSPLRIWHSLKLFGLAMKMLVPNLKAEGVSQMLFPANAAAYHKSYMAATTL