| Entry | Q6Q3H3 |
Entry Name | TPSGD_VITVI |
| Sequence Status | reviewed |
| Protein Name | (-)-germacrene D synthase (EC 4.2.3.22) (EC 4.2.3.75) |
| Sequence Length | 557 |
| Gene Name | VIT_19s0014g04930 VIT_00014569001 VITISV_013313 VITISV_030783 Vv19s0014g04930 |
| Organism | Vitis vinifera (Grape) |
| EC Number | 4.2.3.22; 4.2.3.75 |
Protein Function | FUNCTION: Involved in the biosynthesis of germacrene D. Can use farnesyl diphosphate as substrate, but not geranyl diphosphate or geranylgeranyl diphosphate. Produces mainly (-)-germacrene D along with gamma-cadinene. {ECO:0000269|PubMed:15464152}. |
Pathway | PATHWAY: Secondary metabolite biosynthesis; terpenoid biosynthesis. |
Protein Active Site | |
Reference | 15464152; 17721507; 18094749 |
Domain | DOMAIN: The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg(2+). {ECO:0000250}. |
Motif | MOTIF 310 314 DDXXD motif. |
Protein Family | Terpene synthase family, Tpsa subfamily |
Ensembl ID | |
Biocyc ID | PF01397;PF03936; |
Protein Existence | Evidence at protein level |
Subunit Structure | |
Gene Ontology Biological Process | terpenoid biosynthetic process [GO:0016114] |
Gene Ontology Cellular Component | cytoplasm [GO:0005737] |
Gene Ontology | cytoplasm [GO:0005737]; germacradienol synthase activity [GO:0034004]; germacrene-D synthase activity [GO:0052577]; magnesium ion binding [GO:0000287]; terpenoid biosynthetic process [GO:0016114] |
Gene Ontology Molecular Function | germacradienol synthase activity [GO:0034004]; germacrene-D synthase activity [GO:0052577]; magnesium ion binding [GO:0000287] |
GO ID | GO:0000287; GO:0005737; GO:0016114; GO:0034004; GO:0052577 |
String Database | 29760.VIT_19s0014g04930.t01; |
PDB | |
RefSeq | NP_001268213.1; |
KEGG | vvi:100232954; |
InterPro | IPR008949;IPR034741;IPR001906;IPR036965;IPR005630;IPR008930; |
Protein Sequence | MSVQSSGVLLAPSKNLSPEVGRRCANFHPSIWGDHFLSYASEFTNTDDHLKQHVQQLKEEVRKMLMAADDDSAQKLLLIDAIQRLGVAYHFESEIDEVLKHMFDGSVVSAEEDVYTASLRFRLLRQQGYHVSCDLFNNFKDNEGNFKESLSSDVRGMLSLYEATHFRVHGEDILDEALAFTTTHLQSATKHSSNPLAEQVVHALKQPIRKGLPRLEARHYFSVYQADDSHNKALLKLAKLDFNLLQKLHQKELSDISAWWKDLDFAHKLPFARDRVVECYFWILGVYFEPQFFFARRILTKVIAMTSIIDDIYDVYGTLEELELFTEAVERWDISAIDQLPEYMRVCYQALLYVYSEIEEEMAKEGRSYRLYYAKEAMKNQVRAYYEEAKWLQVQQIPTMEEYMPVALVTSAYSMLATTSFVGMGDAVTKESFDWIFSKPKIVRASAIVCRLMDDMVFHKFEQKRGHVASAVECYMKQHGASEQETPNEFPQPVREAWKDINEECLIPTAVPMPILMRVLNLARVIDVIYKNEDGYTHFGAVLKDFVTSMLIDPVPI |
