TerSynDB

Plant Name: Q84UU4
Terpene synthases genes
Entry Q84UU4
Entry NameHUMS_ARATH
Sequence Statusreviewed
Protein NameAlpha-humulene/(-)-(E)-beta-caryophyllene synthase (EC 4.2.3.-) (Terpenoid synthase 21) (AtTPS21)
Sequence Length547
Gene NameTPS21 PUP8 At5g23960 MZF18.16
OrganismArabidopsis thaliana (Mouse-ear cress)
EC Number4.2.3.-
Protein FunctionFUNCTION: Involved in sesquiterpene (C15) biosynthesis. The major products are beta-caryophyllene and alpha-humulene. Does not convert geranyl diphosphate (GPP) to any monoterpenes. {ECO:0000269|PubMed:12566586, ECO:0000269|PubMed:15918888}.
PathwayPATHWAY: Secondary metabolite biosynthesis; terpenoid biosynthesis.
Protein Active Site
Reference12566586; 12805595; 9628582; 12207221; 12777052; 15918888; 18400103
DomainDOMAIN: The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg(2+).
MotifMOTIF 299 303 DDXXD motif.
Protein FamilyTerpene synthase family, Tpsa subfamily
Ensembl IDAT5G23960.1 [Q84UU4-1];AT5G23960.2 [Q84UU4-2];
Biocyc IDPF01397;PF03936;
Protein ExistenceEvidence at protein level
Subunit Structure
Gene Ontology Biological Process response to herbivore [GO:0080027]; sesquiterpene biosynthetic process [GO:0051762]; sesquiterpenoid biosynthetic process [GO:0016106]
Gene Ontology Cellular Componentcytoplasm [GO:0005737]
Gene Ontologycytoplasm [GO:0005737]; (-)-E-beta-caryophyllene synthase activity [GO:0080016]; alpha-humulene synthase activity [GO:0080017]; magnesium ion binding [GO:0000287]; response to herbivore [GO:0080027]; sesquiterpene biosynthetic process [GO:0051762]; sesquiterpenoid biosynthetic process [GO:0016106]
Gene Ontology Molecular Function (-)-E-beta-caryophyllene synthase activity [GO:0080016]; alpha-humulene synthase activity [GO:0080017]; magnesium ion binding [GO:0000287]
GO IDGO:0000287; GO:0005737; GO:0016106; GO:0051762; GO:0080016; GO:0080017; GO:0080027
String Database3702.AT5G23960.1;
PDB
RefSeqNP_001190374.1 [Q84UU4-2];NP_197784.2 [Q84UU4-1];
KEGGath:AT5G23960;
InterProIPR008949;IPR034741;IPR001906;IPR036965;IPR005630;IPR008930;
Protein SequenceMGSEVNRPLADFPANIWEDPLTSFSKSDLGTETFKEKHSTLKEAVKEAFMSSKANPIENIKFIDALCRLGVSYHFEKDIVEQLDKSFDCLDFPQMVRQEGCDLYTVGIIFQVFRQFGFKLSADVFEKFKDENGKFKGHLVTDAYGMLSLYEAAQWGTHGEDIIDEALAFSRSHLEEISSRSSPHLAIRIKNALKHPYHKGISRIETRQYISYYEEEESCDPTLLEFAKIDFNLLQILHREELACVTRWHHEMEFKSKVTYTRHRITEAYLWSLGTYFEPQYSQARVITTMALILFTALDDMYDAYGTMEELELFTDAMDEWLPVVPDEIPIPDSMKFIYNVTVEFYDKLDEELEKEGRSGCGFHLKKSLQKTANGYMQEAKWLKKDYIATFDEYKENAILSSGYYALIAMTFVRMTDVAKLDAFEWLSSHPKIRVASEIISRFTDDISSYEFEHKREHVATGIDCYMQQFGVSKERAVEVMGNIVSDAWKDLNQELMRPHVFPFPLLMRVLNLSRVIDVFYRYQDAYTNPKLLKEHIVSLLIETIPI