| Entry | Q9SM02 |
Entry Name | ERG14_ARATH |
| Sequence Status | reviewed |
| Protein Name | Squalene epoxidase 1 (AtSQE1) (EC 1.14.14.17) (Protein DROUGHT HYPERSENSITIVE 2) (Squalene monooxygenase) (XF1 protein) |
| Sequence Length | 531 |
| Gene Name | SQE1 DRY2 XF1 At1g58440 F9K23.3 |
| Organism | Arabidopsis thaliana (Mouse-ear cress) |
| EC Number | 1.14.14.17 |
Protein Function | FUNCTION: Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway. Can produce not only oxidosqualene, but also 2,3:22,23-dioxidosqualene. Main squalene epoxidase in the root. Sqe1 mutants may show defects in membrane lipid rafts, impairing the correct localization of RHD2 NADPH oxidase and the proper polarized production of ROS. {ECO:0000269|PubMed:17426032, ECO:0000269|PubMed:19309460, ECO:0000269|PubMed:19847116}. |
Pathway | PATHWAY: Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 2/3. |
Protein Active Site | |
Reference | 10548732; 11130712; 21810963; 14593172; 17426032; 19309460; 19847116 |
Domain | |
Motif | |
Protein Family | Squalene monooxygenase family |
Ensembl ID | AT1G58440.1; |
Biocyc ID | PF08491; |
Protein Existence | Evidence at protein level |
Subunit Structure | |
Gene Ontology Biological Process | response to water deprivation [GO:0009414]; sterol biosynthetic process [GO:0016126] |
Gene Ontology Cellular Component | endoplasmic reticulum [GO:0005783]; integral component of membrane |
Gene Ontology | endoplasmic reticulum [GO:0005783]; integral component of membrane [GO:0016021]; flavin adenine dinucleotide binding [GO:0050660]; squalene monooxygenase activity [GO:0004506]; response to water deprivation [GO:0009414]; sterol biosynthetic process [GO:0016126] |
Gene Ontology Molecular Function | flavin adenine dinucleotide binding [GO:0050660]; squalene monooxygenase activity [GO:0004506] |
GO ID | GO:0004506; GO:0005783; GO:0009414; GO:0016021; GO:0016126; GO:0050660 |
String Database | 3702.AT1G58440.1; |
PDB | |
RefSeq | NP_564734.1; |
KEGG | ath:AT1G58440; |
InterPro | IPR036188;IPR013698; |
Protein Sequence | MESQLWNWILPLLISSLLISFVAFYGFFVKPKRNGLRHDRKTVSTVTSDVGSVNITGDTVADVIVVGAGVAGSALAYTLGKDKRRVHVIERDLSEPDRIVGELLQPGGYLKLLELGIEDCVEEIDAQRVYGYALFKNGKRIRLAYPLEKFHEDVSGRSFHNGRFIQRMREKAASLPNVQLEQGTVLSLLEENGTIKGVRYKNKAGEEQTAFAALTIVCDGCFSNLRRSLCNPQVEVPSCFVGLVLENCNLPYANHGHVVLADPSPILMYPISSTEVRCLVDVPGQKVPSIANGEMKNYLKTVVAPQMPHEVYDSFIAAVDKGNIKSMPNRSMPASPYPTPGALLMGDAFNMRHPLTGGGMTVALADIVVLRNLLRPLRDLSDGASLCKYLESFYTLRKPVAATINTLANALYQVFCSSENEARNEMREACFDYLGLGGMCTSGPVSLLSGLNPRPLTLVCHFFAVAVYGVIRLLIPFPSPKRIWLGAKLISGASGIIFPIIKAEGVRQMFFPATVPAYYYKAPTVGETKCS |
