AromaDb: A Database of Plant's Aroma Molecules

Hydrochlorothiazide Details

: IUPAC Name
6-chloro-1,1-dioxo-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide
:Chemical Class
:CAS Registry Number
58-93-5
:Description

:Fragrance Type

Physical and Chemical properties

PUBCHEM ID3639
Molecular Weight (mg/mol)297.739
Molecular FormulaC7H8ClN3O4S2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count1
IUPAC Name6-chloro-1,1-dioxo-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide
Canonical SMILESNS(=O)(=O)c1cc2c(cc1Cl)NCNS2(=O)=O
PUBCHEM IUPAC INCHIKEYJZUFKLXOESDKRF-UHFFFAOYSA-N
Solubility Level3
Vapour Pressure-10.144

Absorption and Metabolism information

XLOGP3 AA
CACTVS TPSA135
BBB Level4
Absorption Level0
EXT PPB#Prediction0
AlogP98-0.28
EXT CYP2D6#Prediction0

Toxicological Information

Mouse Female FDANon-Carcinogen
Mouse Male FDASingle-Carcinogen
Rat Female FDANon-Carcinogen
Rat Male FDANon-Carcinogen
Ames PredictionNon-Mutagen
Developmental / Reproductive ToxicityNon-Toxic
Rat Oral LD504.4215 g/kg_body_weight
Ocular IrritancyMild
Hepatotoxic#Prediction0
Effected Human Genes

Ecological Information

Aerobic Biodegradability PredictionNon-Degradable

Hazard(s) Identification

Physical hazardsnot classified
Health hazards None
Environmental hazardsnot classified
About Table Headings

Compound Biological Activity

Serial No.Cas No Gene SymbolOrganismInteraction Interaction ActionsPubMed Id
1 58-93-5 ACE Rattus norvegicus Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of ACE mRNA] decreases^reaction|increases^expression 16326922
2 58-93-5 ACE Rattus norvegicus Hydrochlorothiazide results in increased expression of ACE mRNA increases^expression 18796534
3 58-93-5 ACTA1 Rattus norvegicus Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of ACTA1 mRNA] decreases^reaction|increases^expression 16326922
4 58-93-5 ADIPOQ Mus musculus Hydrochlorothiazide results in decreased expression of ADIPOQ mRNA decreases^expression 19730415
5 58-93-5 AGTR1A Rattus norvegicus Hydrochlorothiazide results in decreased expression of AGTR1A mRNA decreases^expression 18796534
6 58-93-5 ALB Bos taurus Hydrochlorothiazide binds to ALB protein affects^binding 18059056
7 58-93-5 AQP2 Rattus norvegicus Hydrochlorothiazide inhibits the reaction [Lithium results in decreased expression of AQP2 protein] decreases^expression|decreases^reaction 15504936
8 58-93-5 AQP2 Rattus norvegicus Hydrochlorothiazide results in decreased expression of AQP2 mRNA decreases^expression 17584643
9 58-93-5 AQP2 Rattus norvegicus Hydrochlorothiazide results in decreased expression of AQP2 protein decreases^expression 17584643
10 58-93-5 ATP6V1B1 Rattus norvegicus Hydrochlorothiazide results in increased expression of ATP6V1B1 protein increases^expression 17311909
11 58-93-5 AVPR2 Rattus norvegicus Hydrochlorothiazide results in decreased expression of AVPR2 mRNA decreases^expression 17584643
12 58-93-5 BDKRB1 Rattus norvegicus Hydrochlorothiazide results in decreased expression of BDKRB1 mRNA decreases^expression 18796534
13 58-93-5 CAT Rattus norvegicus [Hydrochlorothiazide co-treated with Fructose] results in decreased activity of CAT protein affects^cotreatment|decreases^activity 23707192
14 58-93-5 CAT Rattus norvegicus Hydrochlorothiazide results in decreased activity of CAT protein decreases^activity 23707192
15 58-93-5 CCL2 Rattus norvegicus Hydrochlorothiazide results in decreased expression of CCL2 mRNA decreases^expression 19627010
16 58-93-5 CDKN1B Rattus norvegicus [troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of CDKN1B protein affects^cotreatment|decreases^expression 11318962
17 58-93-5 CDKN2A Rattus norvegicus [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine] inhibits the reaction [Desoxycorticosterone Acetate affects the localization of CDKN2A protein] affects^cotreatment|affects^localization|decreases^reaction 18504326
18 58-93-5 CDKN2A Rattus norvegicus [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine] inhibits the reaction [Desoxycorticosterone Acetate results in increased expression of CDKN2A mRNA] affects^cotreatment|decreases^reaction|increases^expression 18504326
19 58-93-5 CMA1 Rattus norvegicus Hydrochlorothiazide affects the expression of CMA1 mRNA affects^expression 18796534
20 58-93-5 CYBA Rattus norvegicus Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of CYBA] decreases^expression|increases^reaction 21107329
21 58-93-5 CYBB Rattus norvegicus Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of CYBB] decreases^expression|increases^reaction 21107329
22 58-93-5 CYP11B2 Rattus norvegicus Hydrochlorothiazide results in increased expression of CYP11B2 mRNA increases^expression 18796534
23 58-93-5 EDN1 Rattus norvegicus Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of EDN1 mRNA] decreases^reaction|increases^expression 16326922
24 58-93-5 FLT1 Rattus norvegicus [Hydralazine co-treated with Hydrochlorothiazide] inhibits the reaction [Cyclosporine results in increased expression of FLT1 mRNA] affects^cotreatment|decreases^reaction|increases^expression 12110003
25 58-93-5 HLA-DPA1 Homo sapiens Hydrochlorothiazide affects the expression of HLA-DPA1 mRNA affects^expression 25811541
26 58-93-5 HLA-DRB1 Homo sapiens Hydrochlorothiazide affects the expression of HLA-DRB1 mRNA affects^expression 25811541
27 58-93-5 HLA-E Homo sapiens Hydrochlorothiazide affects the expression of HLA-E mRNA affects^expression 25811541
28 58-93-5 HLA-F Homo sapiens Hydrochlorothiazide affects the expression of HLA-F mRNA affects^expression 25811541
29 58-93-5 KLK1 Rattus norvegicus Hydrochlorothiazide results in increased expression of KLK1 mRNA increases^expression 18796534
30 58-93-5 LEPR Mus musculus LEPR mutant form results in increased susceptibility to Hydrochlorothiazide increases^response to substance 22949526
31 58-93-5 MR1 Homo sapiens Hydrochlorothiazide affects the expression of MR1 mRNA affects^expression 25811541
32 58-93-5 MYH7 Rattus norvegicus Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of MYH7 mRNA] decreases^reaction|increases^expression 16326922
33 58-93-5 NOS3 Rattus norvegicus Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in decreased expression of NOS3 protein] decreases^expression|decreases^reaction 16197366
34 58-93-5 NOX1 Rattus norvegicus Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of NOX1] decreases^expression|increases^reaction 21107329
35 58-93-5 NOX4 Rattus norvegicus Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of NOX4] decreases^expression|increases^reaction 21107329
36 58-93-5 NPPB Rattus norvegicus Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of NPPB mRNA] decreases^reaction|increases^expression 16326922
37 58-93-5 NR3C2 Rattus norvegicus Hydrochlorothiazide results in increased expression of NR3C2 mRNA increases^expression 18796534
38 58-93-5 PCNA Rattus norvegicus [troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of PCNA protein affects^cotreatment|decreases^expression 11318962
39 58-93-5 PTGS2 Rattus norvegicus [rofecoxib results in decreased activity of PTGS2 protein] inhibits the reaction [Hydrochlorothiazide results in increased abundance of Prostaglandins] decreases^activity|decreases^reaction|increases^abundance 11703585
40 58-93-5 RAMP2 Rattus norvegicus Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of RAMP2 protein] decreases^reaction|increases^expression 16326922
41 58-93-5 RAMP3 Rattus norvegicus Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of RAMP3 protein] decreases^reaction|increases^expression 16326922
42 58-93-5 REN Homo sapiens Hydrochlorothiazide results in increased activity of REN protein increases^activity 1930859|2920503
43 58-93-5 REN Homo sapiens Hydrochlorothiazide results in increased expression of REN protein increases^expression 12569265
44 58-93-5 REN Homo sapiens Losartan promotes the reaction [Hydrochlorothiazide results in increased expression of REN protein] increases^expression|increases^reaction 12569265
45 58-93-5 REN Homo sapiens Sodium affects the reaction [Hydrochlorothiazide results in increased activity of REN protein] affects^reaction|increases^activity 1930859
46 58-93-5 SERPINE1 Rattus norvegicus [troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of SERPINE1 mRNA affects^cotreatment|decreases^expression 11318962
47 58-93-5 SERPINE1 Rattus norvegicus [troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of SERPINE1 protein affects^cotreatment|decreases^expression 11318962
48 58-93-5 SLC12A3 Hydrochlorothiazide results in decreased activity of SLC12A3 protein decreases^activity 21963515|22949526
49 58-93-5 SLC22A6 Rattus norvegicus Hydrochlorothiazide results in increased expression of SLC22A6 protein increases^expression 12897087
50 58-93-5 SLC12A4 Oryctolagus cuniculus Trichlormethiazide results in decreased activity of SLC12A4 protein decreases^activity 10913127
51 58-93-5 SLC12A7 Mus musculus Trichlormethiazide results in decreased activity of SLC12A7 protein decreases^activity 10913127
52 58-93-5 TPMT Homo sapiens Trichlormethiazide results in decreased activity of TPMT protein decreases^activity 8866635
Serial No.Activity Name DetailsReferences (PubMed)Other details EPA (U.S)Clinical Trials (U.S. NIH)
1 58-93-5 Hydrochlorothiazide

Plant Variety and Essential oils

Serial No.Plant NameVariety NameEssential OilCompound Percentage
1 Mulethi Mishri Glucyrrhiza glabra mulethi essential oil

Compound Image


2D Structure

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