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DbMDR is a non-redundant reference database of multi drug resistance (MDR) genes found in all forms of life such as archaea, eubacteria, fungi, plants and animals. MDR is a serious complication during treatment of opportunistic pathogenic infections that frequently affect immuno-compromised individuals, such as transplant recipients and cancer patients undergoing cytotoxic chemotherapy. Drug resistance is a common phenomenon in various pathogens and now creating a serious problem of inactivation of various drugs including antibiotics against many diseases like malaria, tuberculosis etc. Apart from other factors, several MDR genes, which are present in these pathogens, are responsible for this phenomenon. There is a vital need for such comprehensive database related to MDR genes which covers mechanism against combating drugs. Details of total 1294 MDR genes are covered in the database and for each gene, almost 10-20 descriptors are included. Most of the information in the database is supported with scientific literature and proper citations. Molecular data of MDR genes were extracted from previously published reports on drug resistance. In addition to the MDR genes originally reported, their orthologs in other organisms are also compiled. Documents for each MDR gene in the database contains, in addition to a gene sequence, a brief definition and description of each gene and relevant literature with PubMed ID numbers and GenBank (NCBI) ID where available. Users can search their query for MDR genes using the search program at our website. Clicking the DbMDR ID in the result report will open the pertinent gene document. Clicking the PubMed ID or GenBank (NCBI) ID in the document will allow users to access to these databases and to read the abstract of the literature or the annotation in the DNA database. |