| TerSyn Pathway : Geraniol and geranial biosynthesis |
Reaction: EC 1.1.1.183 geranyl diphosphate + H2O = geraniol + diphosphate.
Reaction: EC 3.1.7.11 geranyl diphosphate + H2O = geraniol + diphosphate
|
| Geraniol and geranial biosynthesis pathway mapping |
|---|
Geraniol (3,7-dimethylocta-trans-2,6-dien-1-ol) is an acyclic monoterpene alcohol with the chemical formula C10H18O, which is widely used in the perfume industry due to its pleasant odor ( Chen and Viljoen, 2010). In addition, geraniol is known to exhibit insecticidal and insect repellent properties, and has also been developed as a chemo-prevention agent for the treatment of cancer ( Kim et al., 2011). However, geraniol is naturally produced in limited quantities (Bakkali et al., 2008). Therefore, biosynthesis of such rare and valuable compounds in microorganisms by metabolic engineering strategies is a feasible route to fulfill the increasing commercial demand... |
S.NO |
E1 (Geranyl diphosphate synthase) (Accession no [AAF08793.1]) (%identity [100] ) |
E2 (geraniol synthase) |
E3 (Geraniol dehydrogenase) |
|---|---|---|---|
1 |
Populus trichocarpa [XP_002310785.1/74] |
YES [AEI52903.1/ 38] |
YES [XP_002322761.2/ 75] |
2 |
Ricinus communis [XP_002525096.1/ 73] |
YES [XP_002515692.1/ 42] |
YES [XP_002534286.1/70] |
3 |
Medicago truncatula [XP_003629488.1/71] |
YES [XP_003597053.1/ 54] |
YES [AES95931.1/ 68] |
4 |
Fragaria vesca subsp. vesca [XP_004300598.1/70] |
YES [P0CV96.1/ 40] |
YES [XP_004307159.1/73] |
5 |
Catharanthus roseus [AGL91645.1/ 69] |
YES [AFD64744.1/ 66] |
YES [Q6V4H0.1/ 77] |
6 |
Vitis vinifera [XP_002273789.1/ 69] |
YES [ADR74217.1/ 53] |
YES [XP_003635435.1/73] |
7 |
Glycine max [XP_003547995.1/ 69] |
YES [XP_003540326.1/53] |
YES [NP_001240222.1/70] |
8 |
Solanum tuberosum [XP_006363135.1/ 68] |
YES [XP_006351844.1/41] |
YES [CAD29291.1/70] |
9 |
Phaseolus vulgaris [ESW28009.1/ 68] |
YES [ESW21931.1/ 49] |
YES [ESW30336.1/70] |
10 |
Solanum lycopersicum [NP_001234087.1/ 67] |
YES [XP_004230556.1/ 49] |
YES [XP_004250169.1/71] |
11 |
Citrus sinensis [XP_006466719.1/ 65] |
YES [XP_006469778.1/ 53] |
YES [XP_006466347.1/70] |
12 |
Theobroma cacao [EOX91186.1/ 65] |
NO |
YES [EOX91887.1/65] |
13 |
Citrus clementina [XP_006425738.1/ 64] |
NO |
YES [XP_006426239.1/71] |
14 |
Prunus persica [EMJ05575.1/ 69] |
NO |
YES [EMJ06613.1/ 74] |
| References: | |
| 1. | Biosynthesis of geraniol and nerol and their β-d-glucosides in Perlargonium graveolens and Rosa dilecta Derek V. Banthorpe and Geoffrey N. J. Le Patourel; Martin J. O. Francis |
| 2. | "Geraniol dehydrogenase: a determinant of essential oil quality in lemongrass1." SinghSangwan93: Singh-Sangwan N, Sangwan RS, Luthra R, Thakur RS (1993). Planta Med 59(2);168-70. PMID: 17230350 |