TerSynDB

Plant Name: O65403
Terpene synthases genes
Entry O65403
Entry NameERG13_ARATH
Sequence Statusreviewed
Protein NameSqualene epoxidase 4 (AtSQE4) (EC 1.14.14.17) (Squalene monooxygenase 2) (SE 2)
Sequence Length516
Gene NameSQE4 SQP2 At5g24140 MLE8.6
OrganismArabidopsis thaliana (Mouse-ear cress)
EC Number1.14.14.17
Protein FunctionFUNCTION: Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway. {ECO:0000250|UniProtKB:Q9SM02}.
PathwayPATHWAY: Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 2/3.
Protein Active Site
Reference10350086; 9679202; 10048488; 17426032
Domain
Motif
Protein FamilySqualene monooxygenase family
Ensembl ID
Biocyc IDPF01266;PF08491;
Protein ExistenceEvidence at transcript level
Subunit Structure
Gene Ontology Biological Process
Gene Ontology Cellular Componentendoplasmic reticulum [GO:0005783]; integral component of membrane
Gene Ontologyendoplasmic reticulum [GO:0005783]; integral component of membrane [GO:0016021]; flavin adenine dinucleotide binding [GO:0050660]; squalene monooxygenase activity [GO:0004506]
Gene Ontology Molecular Function flavin adenine dinucleotide binding [GO:0050660]; squalene monooxygenase activity [GO:0004506]
GO IDGO:0004506; GO:0005783; GO:0016021; GO:0050660
String Database3702.AT5G24140.1;
PDB
RefSeqNP_197802.2;
KEGGath:AT5G24140;
InterProIPR006076;IPR036188;IPR013698;
Protein SequenceMTYAWLWTLLAFVLTWMVFHLIKMKKAATGDLEAEAEARRDGATDVIIVGAGVAGASLAYALAKDGRRVHVIERDLKEPQRFMGELMQAGGRFMLAQLGLEDCLEDIDAQEAKSLAIYKDGKHATLPFPDDKSFPHEPVGRLLRNGRLVQRLRQKAASLSNVQLEEGTVKSLIEEEGVVKGVTYKNSAGEEITAFAPLTVVCDGCYSNLRRSLVDNTEEVLSYMVGYVTKNSRLEDPHSLHLIFSKPLVCVIYQITSDEVRCVAEVPADSIPSISNGEMSTFLKKSMAPQIPETGNLREIFLKGIEEGLPEIKSTATKSMSSRLCDKRGVIVLGDAFNMRHPIIASGMMVALSDICILRNLLKPLPNLSNTKKVSDLVKSFYIIRKPMSATVNTLASIFSQVLVATTDEAREGMRQGCFNYLARGDFKTRGLMTILGGMNPHPLTLVLHLVAITLTSMGHLLSPFPSPRRFWHSLRILAWALQMLGAHLVDEGFKEMLIPTNAAAYRRNYIATTTV
CSIR-CIMAP