| Entry | Q84LB2 |
Entry Name | AFS1_MALDO |
| Sequence Status | reviewed |
| Protein Name | (E,E)-alpha-farnesene synthase (MdASF1) (EC 4.2.3.46) (Prenyltransferase) (EC 2.5.1.-) |
| Sequence Length | 576 |
| Gene Name | AFS1 AFAR |
| Organism | Malus domestica (Apple) (Pyrus malus) |
| EC Number | 4.2.3.46; 2.5.1.- |
Protein Function | FUNCTION: Sesquiterpene synthase catalyzing the production of (E,E)-alpha-farnesene, the predominant terpene produced during storage of fruits. Produces all six isomers (E,E)-alpha-farnesene, (Z,E)-alpha-farnesene, (E,Z)-alpha-farnesene, (Z,Z)-alpha-farnesene, (E)-beta-farnesene and (Z)-beta-farnesene from a mix of isomeric forms of the farnesyl diphosphate precursor. Able to convert geranyl diphosphate to the monoterpenes (E)-beta-ocimene, linalool and beta-myrcene. Has also a prenyltransferase activity producing alpha-farnesene directly from geranyl diphosphate and isoprenyl diphosphate. |
Pathway | |
Protein Active Site | |
Reference | 14740213; 17140613; 19181671 |
Domain | |
Motif | |
Protein Family | Terpene synthase family, Tpsb subfamily |
Ensembl ID | |
Biocyc ID | PF01397;PF03936; |
Protein Existence | Evidence at protein level |
Subunit Structure | SUBUNIT: Monomer. {ECO:0000269|PubMed:17140613}. |
Gene Ontology Biological Process | metabolic process [GO:0008152] |
Gene Ontology Cellular Component | cytoplasm [GO:0005737] |
Gene Ontology | cytoplasm [GO:0005737]; magnesium ion binding [GO:0000287]; terpene synthase activity [GO:0010333]; transferase activity [GO:0016740]; metabolic process [GO:0008152] |
Gene Ontology Molecular Function | magnesium ion binding [GO:0000287]; terpene synthase activity [GO:0010333]; transferase activity [GO:0016740] |
GO ID | GO:0000287; GO:0005737; GO:0008152; GO:0010333; GO:0016740 |
String Database | |
PDB | |
RefSeq | NP_001280822.1; |
KEGG | mdm:103446592; |
InterPro | IPR008949;IPR034741;IPR001906;IPR036965;IPR005630;IPR008930; |
Protein Sequence | MEFRVHLQADNEQKIFQNQMKPEPEASYLINQRRSANYKPNIWKNDFLDQSLISKYDGDEYRKLSEKLIEEVKIYISAETMDLVAKLELIDSVRKLGLANLFEKEIKEALDSIAAIESDNLGTRDDLYGTALHFKILRQHGYKVSQDIFGRFMDEKGTLENHHFAHLKGMLELFEASNLGFEGEDILDEAKASLTLALRDSGHICYPDSNLSRDVVHSLELPSHRRVQWFDVKWQINAYEKDICRVNATLLELAKLNFNVVQAQLQKNLREASRWWANLGIADNLKFARDRLVECFACAVGVAFEPEHSSFRICLTKVINLVLIIDDVYDIYGSEEELKHFTNAVDRWDSRETEQLPECMKMCFQVLYNTTCEIAREIEEENGWNQVLPQLTKVWADFCKALLVEAEWYNKSHIPTLEEYLRNGCISSSVSVLLVHSFFSITHEGTKEMADFLHKNEDLLYNISLIVRLNNDLGTSAAEQERGDSPSSIVCYMREVNASEETARKNIKGMIDNAWKKVNGKCFTTNQVPFLSSFMNNATNMARVAHSLYKDGDGFGDQEKGPRTHILSLLFQPLVN |
