| Entry | Q84UU4 |
Entry Name | HUMS_ARATH |
| Sequence Status | reviewed |
| Protein Name | Alpha-humulene/(-)-(E)-beta-caryophyllene synthase (EC 4.2.3.-) (Terpenoid synthase 21) (AtTPS21) |
| Sequence Length | 547 |
| Gene Name | TPS21 PUP8 At5g23960 MZF18.16 |
| Organism | Arabidopsis thaliana (Mouse-ear cress) |
| EC Number | 4.2.3.- |
Protein Function | FUNCTION: Involved in sesquiterpene (C15) biosynthesis. The major products are beta-caryophyllene and alpha-humulene. Does not convert geranyl diphosphate (GPP) to any monoterpenes. {ECO:0000269|PubMed:12566586, ECO:0000269|PubMed:15918888}. |
Pathway | PATHWAY: Secondary metabolite biosynthesis; terpenoid biosynthesis. |
Protein Active Site | |
Reference | 12566586; 12805595; 9628582; 12207221; 12777052; 15918888; 18400103 |
Domain | DOMAIN: The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg(2+). |
Motif | MOTIF 299 303 DDXXD motif. |
Protein Family | Terpene synthase family, Tpsa subfamily |
Ensembl ID | AT5G23960.1 [Q84UU4-1];AT5G23960.2 [Q84UU4-2]; |
Biocyc ID | PF01397;PF03936; |
Protein Existence | Evidence at protein level |
Subunit Structure | |
Gene Ontology Biological Process | response to herbivore [GO:0080027]; sesquiterpene biosynthetic process [GO:0051762]; sesquiterpenoid biosynthetic process [GO:0016106] |
Gene Ontology Cellular Component | cytoplasm [GO:0005737] |
Gene Ontology | cytoplasm [GO:0005737]; (-)-E-beta-caryophyllene synthase activity [GO:0080016]; alpha-humulene synthase activity [GO:0080017]; magnesium ion binding [GO:0000287]; response to herbivore [GO:0080027]; sesquiterpene biosynthetic process [GO:0051762]; sesquiterpenoid biosynthetic process [GO:0016106] |
Gene Ontology Molecular Function | (-)-E-beta-caryophyllene synthase activity [GO:0080016]; alpha-humulene synthase activity [GO:0080017]; magnesium ion binding [GO:0000287] |
GO ID | GO:0000287; GO:0005737; GO:0016106; GO:0051762; GO:0080016; GO:0080017; GO:0080027 |
String Database | 3702.AT5G23960.1; |
PDB | |
RefSeq | NP_001190374.1 [Q84UU4-2];NP_197784.2 [Q84UU4-1]; |
KEGG | ath:AT5G23960; |
InterPro | IPR008949;IPR034741;IPR001906;IPR036965;IPR005630;IPR008930; |
Protein Sequence | MGSEVNRPLADFPANIWEDPLTSFSKSDLGTETFKEKHSTLKEAVKEAFMSSKANPIENIKFIDALCRLGVSYHFEKDIVEQLDKSFDCLDFPQMVRQEGCDLYTVGIIFQVFRQFGFKLSADVFEKFKDENGKFKGHLVTDAYGMLSLYEAAQWGTHGEDIIDEALAFSRSHLEEISSRSSPHLAIRIKNALKHPYHKGISRIETRQYISYYEEEESCDPTLLEFAKIDFNLLQILHREELACVTRWHHEMEFKSKVTYTRHRITEAYLWSLGTYFEPQYSQARVITTMALILFTALDDMYDAYGTMEELELFTDAMDEWLPVVPDEIPIPDSMKFIYNVTVEFYDKLDEELEKEGRSGCGFHLKKSLQKTANGYMQEAKWLKKDYIATFDEYKENAILSSGYYALIAMTFVRMTDVAKLDAFEWLSSHPKIRVASEIISRFTDDISSYEFEHKREHVATGIDCYMQQFGVSKERAVEVMGNIVSDAWKDLNQELMRPHVFPFPLLMRVLNLSRVIDVFYRYQDAYTNPKLLKEHIVSLLIETIPI |
