AromaDb: A Database of Plant's Aroma Molecules

Carvacrol Details

: IUPAC Name
2-methyl-5-propan-2-ylphenol
:Chemical Class
:CAS Registry Number
499-75-2
:Description

:Fragrance Type

Physical and Chemical properties

PUBCHEM ID10364
Molecular Weight (mg/mol)150.218
Molecular FormulaC10H14O
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count1
IUPAC Name2-methyl-5-propan-2-ylphenol
Canonical SMILESCc1ccc(C(C)C)cc1O
PUBCHEM IUPAC INCHIKEYRECUKUPTGUEGMW-UHFFFAOYSA-N
Solubility Level3
Vapour Pressure-2.144

Absorption and Metabolism information

XLOGP3 AA
CACTVS TPSA20.2
BBB Level1
Absorption Level0
EXT PPB#Prediction1
AlogP983.268
EXT CYP2D6#Prediction0

Toxicological Information

Mouse Female FDAMulti-Carcinogen
Mouse Male FDAMulti-Carcinogen
Rat Female FDANon-Carcinogen
Rat Male FDANon-Carcinogen
Ames PredictionNon-Mutagen
Developmental / Reproductive ToxicityNon-Toxic
Rat Oral LD500.220133 g/kg_body_weight
Ocular IrritancySevere
Hepatotoxic#Prediction1
Effected Human Genes

Ecological Information

Aerobic Biodegradability PredictionNon-Degradable

Hazard(s) Identification

Physical hazardsnot classified
Health hazards Severe
Environmental hazardsnot classified
About Table Headings

Compound Biological Activity

Serial No.Cas No Gene SymbolOrganismInteraction Interaction ActionsPubMed Id
1 499-75-2 ANKRD17 Gallus gallus carvacrol results in increased expression of ANKRD17 mRNA increases^expression 20008804
2 499-75-2 ANKRD17 Gallus gallus carvacrol results in increased expression of ANKRD17 mRNA increases^expression 20008804
3 499-75-2 ANKRD17 Gallus gallus carvacrol results in increased expression of ANKRD17 mRNA increases^expression 20008804
4 499-75-2 AP1S3 Gallus gallus carvacrol results in increased expression of AP1S3 mRNA increases^expression 20008804
5 499-75-2 AP1S3 Gallus gallus carvacrol results in increased expression of AP1S3 mRNA increases^expression 20008804
6 499-75-2 AP1S3 Gallus gallus carvacrol results in increased expression of AP1S3 mRNA increases^expression 20008804
7 499-75-2 CASP3 Homo sapiens carvacrol results in increased activity of CASP3 protein increases^activity 23146755
8 499-75-2 CASP3 Homo sapiens carvacrol results in increased activity of CASP3 protein increases^activity 23146755
9 499-75-2 CASP3 Homo sapiens carvacrol results in increased activity of CASP3 protein increases^activity 23146755
10 499-75-2 CD5 Gallus gallus carvacrol results in increased expression of CD5 mRNA increases^expression 20008804
11 499-75-2 CD5 Gallus gallus carvacrol results in increased expression of CD5 mRNA increases^expression 20008804
12 499-75-2 CD5 Gallus gallus carvacrol results in increased expression of CD5 mRNA increases^expression 20008804
13 499-75-2 COQ5 Gallus gallus carvacrol results in decreased expression of COQ5 mRNA decreases^expression 20008804
14 499-75-2 COQ5 Gallus gallus carvacrol results in decreased expression of COQ5 mRNA decreases^expression 20008804
15 499-75-2 COQ5 Gallus gallus carvacrol results in decreased expression of COQ5 mRNA decreases^expression 20008804
16 499-75-2 CXCL1 Mus musculus 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [irinotecan results in increased expression of CXCL1 protein]] decreases^reaction|increases^expression 27838229
17 499-75-2 CXCL1 Mus musculus 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [irinotecan results in increased expression of CXCL1 protein]] decreases^reaction|increases^expression 27838229
18 499-75-2 CXCL1 Mus musculus 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [irinotecan results in increased expression of CXCL1 protein]] decreases^reaction|increases^expression 27838229
19 499-75-2 CXCL1 Mus musculus carvacrol inhibits the reaction [irinotecan results in increased expression of CXCL1 protein] decreases^reaction|increases^expression 27838229
20 499-75-2 CXCL1 Mus musculus carvacrol inhibits the reaction [irinotecan results in increased expression of CXCL1 protein] decreases^reaction|increases^expression 27838229
21 499-75-2 CXCL1 Mus musculus carvacrol inhibits the reaction [irinotecan results in increased expression of CXCL1 protein] decreases^reaction|increases^expression 27838229
22 499-75-2 DUSP1 Gallus gallus carvacrol results in increased expression of DUSP1 mRNA increases^expression 20008804
23 499-75-2 DUSP1 Gallus gallus carvacrol results in increased expression of DUSP1 mRNA increases^expression 20008804
24 499-75-2 DUSP1 Gallus gallus carvacrol results in increased expression of DUSP1 mRNA increases^expression 20008804
25 499-75-2 FOS Gallus gallus carvacrol results in increased expression of FOS mRNA increases^expression 20008804
26 499-75-2 FOS Gallus gallus carvacrol results in increased expression of FOS mRNA increases^expression 20008804
27 499-75-2 FOS Gallus gallus carvacrol results in increased expression of FOS mRNA increases^expression 20008804
28 499-75-2 HIPK2 Gallus gallus carvacrol results in decreased expression of HIPK2 mRNA decreases^expression 20008804
29 499-75-2 HIPK2 Gallus gallus carvacrol results in decreased expression of HIPK2 mRNA decreases^expression 20008804
30 499-75-2 HIPK2 Gallus gallus carvacrol results in decreased expression of HIPK2 mRNA decreases^expression 20008804
31 499-75-2 IL1B Mus musculus 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [irinotecan results in increased expression of IL1B protein]] decreases^reaction|increases^expression 27838229
32 499-75-2 IL1B Mus musculus 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [irinotecan results in increased expression of IL1B protein]] decreases^reaction|increases^expression 27838229
33 499-75-2 IL1B Mus musculus 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [irinotecan results in increased expression of IL1B protein]] decreases^reaction|increases^expression 27838229
34 499-75-2 IL1B Mus musculus carvacrol inhibits the reaction [irinotecan results in increased expression of IL1B protein] decreases^reaction|increases^expression 27838229
35 499-75-2 IL1B Mus musculus carvacrol inhibits the reaction [irinotecan results in increased expression of IL1B protein] decreases^reaction|increases^expression 27838229
36 499-75-2 IL1B Mus musculus carvacrol inhibits the reaction [irinotecan results in increased expression of IL1B protein] decreases^reaction|increases^expression 27838229
37 499-75-2 LRRC59 Gallus gallus carvacrol results in decreased expression of LRRC59 mRNA decreases^expression 20008804
38 499-75-2 LRRC59 Gallus gallus carvacrol results in decreased expression of LRRC59 mRNA decreases^expression 20008804
39 499-75-2 LRRC59 Gallus gallus carvacrol results in decreased expression of LRRC59 mRNA decreases^expression 20008804
40 499-75-2 MPO Mus musculus 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [irinotecan results in increased activity of MPO protein]] decreases^reaction|increases^activity 27838229
41 499-75-2 MPO Mus musculus 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [irinotecan results in increased activity of MPO protein]] decreases^reaction|increases^activity 27838229
42 499-75-2 MPO Mus musculus 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [irinotecan results in increased activity of MPO protein]] decreases^reaction|increases^activity 27838229
43 499-75-2 MPO Mus musculus carvacrol inhibits the reaction [irinotecan results in increased activity of MPO protein] decreases^reaction|increases^activity 27838229
44 499-75-2 MPO Mus musculus carvacrol inhibits the reaction [irinotecan results in increased activity of MPO protein] decreases^reaction|increases^activity 27838229
45 499-75-2 MPO Mus musculus carvacrol inhibits the reaction [irinotecan results in increased activity of MPO protein] decreases^reaction|increases^activity 27838229
46 499-75-2 MSRB1 Gallus gallus carvacrol results in increased expression of MSRB1 mRNA increases^expression 20008804
47 499-75-2 MSRB1 Gallus gallus carvacrol results in increased expression of MSRB1 mRNA increases^expression 20008804
48 499-75-2 MSRB1 Gallus gallus carvacrol results in increased expression of MSRB1 mRNA increases^expression 20008804
49 499-75-2 NFKB1 Mus musculus carvacrol inhibits the reaction [irinotecan results in increased expression of NFKB1 protein] decreases^reaction|increases^expression 27838229
50 499-75-2 NFKB1 Mus musculus carvacrol inhibits the reaction [irinotecan results in increased expression of NFKB1 protein] decreases^reaction|increases^expression 27838229
51 499-75-2 NFKB1 Mus musculus carvacrol inhibits the reaction [irinotecan results in increased expression of NFKB1 protein] decreases^reaction|increases^expression 27838229
52 499-75-2 OAZ1 Gallus gallus carvacrol results in decreased expression of OAZ1 mRNA decreases^expression 20008804
53 499-75-2 OAZ1 Gallus gallus carvacrol results in decreased expression of OAZ1 mRNA decreases^expression 20008804
54 499-75-2 OAZ1 Gallus gallus carvacrol results in decreased expression of OAZ1 mRNA decreases^expression 20008804
55 499-75-2 PPP1R3B Gallus gallus carvacrol results in decreased expression of PPP1R3B mRNA decreases^expression 20008804
56 499-75-2 PPP1R3B Gallus gallus carvacrol results in decreased expression of PPP1R3B mRNA decreases^expression 20008804
57 499-75-2 PPP1R3B Gallus gallus carvacrol results in decreased expression of PPP1R3B mRNA decreases^expression 20008804
58 499-75-2 PRSS3 Gallus gallus carvacrol results in increased expression of PRSS3 mRNA increases^expression 20008804
59 499-75-2 PRSS3 Gallus gallus carvacrol results in increased expression of PRSS3 mRNA increases^expression 20008804
60 499-75-2 PRSS3 Gallus gallus carvacrol results in increased expression of PRSS3 mRNA increases^expression 20008804
61 499-75-2 PTGS2 Mus musculus carvacrol inhibits the reaction [irinotecan results in increased expression of PTGS2 protein] decreases^reaction|increases^expression 27838229
62 499-75-2 PTGS2 Mus musculus carvacrol inhibits the reaction [irinotecan results in increased expression of PTGS2 protein] decreases^reaction|increases^expression 27838229
63 499-75-2 PTGS2 Mus musculus carvacrol inhibits the reaction [irinotecan results in increased expression of PTGS2 protein] decreases^reaction|increases^expression 27838229
64 499-75-2 RYR1 Sus scrofa carvacrol results in increased activity of RYR1 protein increases^activity 17641978
65 499-75-2 RYR1 Sus scrofa carvacrol results in increased activity of RYR1 protein increases^activity 17641978
66 499-75-2 RYR1 Sus scrofa carvacrol results in increased activity of RYR1 protein increases^activity 17641978
67 499-75-2 SLC15A1 Gallus gallus carvacrol results in decreased expression of SLC15A1 mRNA decreases^expression 20008804
68 499-75-2 SLC15A1 Gallus gallus carvacrol results in decreased expression of SLC15A1 mRNA decreases^expression 20008804
69 499-75-2 SLC15A1 Gallus gallus carvacrol results in decreased expression of SLC15A1 mRNA decreases^expression 20008804
70 499-75-2 SLC34A2 Gallus gallus carvacrol results in decreased expression of SLC34A2 mRNA decreases^expression 20008804
71 499-75-2 SLC34A2 Gallus gallus carvacrol results in decreased expression of SLC34A2 mRNA decreases^expression 20008804
72 499-75-2 SLC34A2 Gallus gallus carvacrol results in decreased expression of SLC34A2 mRNA decreases^expression 20008804
73 499-75-2 STK25 Gallus gallus carvacrol results in decreased expression of STK25 mRNA decreases^expression 20008804
74 499-75-2 STK25 Gallus gallus carvacrol results in decreased expression of STK25 mRNA decreases^expression 20008804
75 499-75-2 STK25 Gallus gallus carvacrol results in decreased expression of STK25 mRNA decreases^expression 20008804
76 499-75-2 TMEM14A Gallus gallus carvacrol results in decreased expression of TMEM14A mRNA decreases^expression 20008804
77 499-75-2 TMEM14A Gallus gallus carvacrol results in decreased expression of TMEM14A mRNA decreases^expression 20008804
78 499-75-2 TMEM14A Gallus gallus carvacrol results in decreased expression of TMEM14A mRNA decreases^expression 20008804
79 499-75-2 TNF Mus musculus 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [irinotecan results in increased expression of TNF protein]] decreases^reaction|increases^expression 27838229
80 499-75-2 TNF Mus musculus 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [irinotecan results in increased expression of TNF protein]] decreases^reaction|increases^expression 27838229
81 499-75-2 TNF Mus musculus 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [irinotecan results in increased expression of TNF protein]] decreases^reaction|increases^expression 27838229
82 499-75-2 TNF Mus musculus carvacrol inhibits the reaction [irinotecan results in increased expression of TNF protein] decreases^reaction|increases^expression 27838229
83 499-75-2 TNF Mus musculus carvacrol inhibits the reaction [irinotecan results in increased expression of TNF protein] decreases^reaction|increases^expression 27838229
84 499-75-2 TNF Mus musculus carvacrol inhibits the reaction [irinotecan results in increased expression of TNF protein] decreases^reaction|increases^expression 27838229
85 499-75-2 TRPA1 Anolis carolinensis carvacrol results in increased activity of TRPA1 protein increases^activity 22791718
86 499-75-2 TRPA1 Anolis carolinensis carvacrol results in increased activity of TRPA1 protein increases^activity 22791718
87 499-75-2 TRPA1 Anolis carolinensis carvacrol results in increased activity of TRPA1 protein increases^activity 22791718
88 499-75-2 TRPA1 carvacrol binds to and results in increased activity of TRPA1 protein affects^binding|increases^activity 20086034
89 499-75-2 TRPA1 carvacrol binds to and results in increased activity of TRPA1 protein affects^binding|increases^activity 20086034
90 499-75-2 TRPA1 carvacrol binds to and results in increased activity of TRPA1 protein affects^binding|increases^activity 20086034
91 499-75-2 TRPL Drosophila melanogaster carvacrol results in decreased activity of TRPL protein decreases^activity 19135721
92 499-75-2 TRPL Drosophila melanogaster carvacrol results in decreased activity of TRPL protein decreases^activity 19135721
93 499-75-2 TRPL Drosophila melanogaster carvacrol results in decreased activity of TRPL protein decreases^activity 19135721
94 499-75-2 TRPM7 Mammalia carvacrol results in decreased activity of TRPM7 protein decreases^activity 19135721
95 499-75-2 TRPM7 Mammalia carvacrol results in decreased activity of TRPM7 protein decreases^activity 19135721
96 499-75-2 TRPM7 Mammalia carvacrol results in decreased activity of TRPM7 protein decreases^activity 19135721
97 499-75-2 TRPV3 Homo sapiens carvacrol results in increased activity of TRPV3 protein increases^activity 16617338
98 499-75-2 TRPV3 Homo sapiens carvacrol results in increased activity of TRPV3 protein increases^activity 16617338
99 499-75-2 TRPV3 Homo sapiens carvacrol results in increased activity of TRPV3 protein increases^activity 16617338
100 499-75-2 TRPV3 Mus musculus [carvacrol results in increased activity of TRPV3 protein] which results in increased transport of Calcium increases^activity|increases^transport 16617338
101 499-75-2 TRPV3 Mus musculus [carvacrol results in increased activity of TRPV3 protein] which results in increased transport of Calcium increases^activity|increases^transport 16617338
102 499-75-2 TRPV3 Mus musculus [carvacrol results in increased activity of TRPV3 protein] which results in increased transport of Calcium increases^activity|increases^transport 16617338
103 499-75-2 TRPV3 Rattus norvegicus carvacrol binds to and results in increased activity of TRPV3 protein affects^binding|increases^activity 20086034
104 499-75-2 TRPV3 Rattus norvegicus carvacrol binds to and results in increased activity of TRPV3 protein affects^binding|increases^activity 20086034
105 499-75-2 TRPV3 Rattus norvegicus carvacrol binds to and results in increased activity of TRPV3 protein affects^binding|increases^activity 20086034
106 499-75-2 TRPV3 Rattus norvegicus [carvacrol binds to and results in increased activity of TRPV3 protein] which results in increased transport of Calcium affects^binding|increases^activity|increases^transport 20086034
107 499-75-2 TRPV3 Rattus norvegicus [carvacrol binds to and results in increased activity of TRPV3 protein] which results in increased transport of Calcium affects^binding|increases^activity|increases^transport 20086034
108 499-75-2 TRPV3 Rattus norvegicus [carvacrol binds to and results in increased activity of TRPV3 protein] which results in increased transport of Calcium affects^binding|increases^activity|increases^transport 20086034
109 499-75-2 TRPV3 Rattus norvegicus Ruthenium Red inhibits the reaction [[carvacrol binds to and results in increased activity of TRPV3 protein] which results in increased transport of Calcium] affects^binding|decreases^reaction|increases^activity|increases^transport 20086034
110 499-75-2 TRPV3 Rattus norvegicus Ruthenium Red inhibits the reaction [[carvacrol binds to and results in increased activity of TRPV3 protein] which results in increased transport of Calcium] affects^binding|decreases^reaction|increases^activity|increases^transport 20086034
111 499-75-2 TRPV3 Rattus norvegicus Ruthenium Red inhibits the reaction [[carvacrol binds to and results in increased activity of TRPV3 protein] which results in increased transport of Calcium] affects^binding|decreases^reaction|increases^activity|increases^transport 20086034
112 499-75-2 TYRR Rhipicephalus microplus carvacrol promotes the reaction [Tyramine results in increased activity of TYRR protein] increases^activity|increases^reaction 27986436
113 499-75-2 TYRR Rhipicephalus microplus carvacrol promotes the reaction [Tyramine results in increased activity of TYRR protein] increases^activity|increases^reaction 27986436
114 499-75-2 TYRR Rhipicephalus microplus carvacrol promotes the reaction [Tyramine results in increased activity of TYRR protein] increases^activity|increases^reaction 27986436
115 499-75-2 VAPB Gallus gallus carvacrol results in decreased expression of VAPB mRNA decreases^expression 20008804
116 499-75-2 VAPB Gallus gallus carvacrol results in decreased expression of VAPB mRNA decreases^expression 20008804
117 499-75-2 VAPB Gallus gallus carvacrol results in decreased expression of VAPB mRNA decreases^expression 20008804
Serial No.Activity Name DetailsReferences (PubMed)Other details EPA (U.S)Clinical Trials (U.S. NIH)
1 499-75-2 Carvacrol

Plant Variety and Essential oils

Serial No.Plant NameVariety NameEssential OilCompound Percentage
1 Scotch spearmint Mukta Mentha X gracilis Mukta essential oil
2 Scotch spearmint Pratik Mentha x gracilis Pratik essential oil
3 Spearmint Arka Mentha spicata Arka essential oil
4 Spearmint MSS-5 Mentha spicata MSS-5 essential oil
5 Spearmint Neerkalka Mentha spicata Neerkalka essential oil
6 Rosemary CIM-Hariyali Rosmarinus officinali CIM-Hariyali essential oil
7 Starflower Borago officinalis essential oil
8 Lemon beebalm, Lemon mint Monarda citriodora essential oil
9 Psyllium, isabgol or isabhghula Mayuri Plantago ovata Mayuri essential oil
10 Psyllium, isabgol or isabhghula Nimisha Plantago ovata Nimisha essential oil
11 Levisticum officinalis Levisticum aofficinalis essential oil
12 Oregano Origanum vulgare essential oil
13 Garden heliotrope Galium odoratum essential oil
14 Yellow bugle Ajuga chamaepitys essential oil
15 Star Thistle Honey Centaurea calcitrapa essential oil
16 Star Thistle Honey Centaurea calcitrapa essential oil
17 Chaerophyllum villosum Chaerophyllum villosum essential oil
18 Chaerophyllum villosum Chaerophyllum villosum essential oil
19 Chikras Chukrasia tabularis essential oil
20 Fireweed Crassocephalum crepidioides essential oil
21 Fireweed Crassocephalum crepidioides essential oil
22 Satureja hortensis Satureja hortensis essential oil
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